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| 1 | Association between early viral lower respiratory tract infections and subsequent asthma development显示文摘BACKGROUND The association between hospitalization for human respiratory syncytial virus(HRSV)bronchiolitis in early childhood and subsequent asthma is well established.The long-term prognosis for non-bronchiolitis lower respiratory tract infections(LRTI)caused by viruses different from HRSV and rhinovirus,on the other hand,has received less interest.AIM To investigate the relationship between infant LRTI and later asthma and examine the influence of confounding factors.METHODS The PubMed and Global Index Medicus bibliographic databases were used to search for articles published up to October 2021 for this systematic review.We included cohort studies comparing the incidence of asthma between patients with and without LRTI at≤2 years regardless of the virus responsible.The meta-analysis was performed using the random effects model.Sources of heterogeneity were assessed by stratified analyses.RESULTS This review included 15 articles(18 unique studies)that met the inclusion criteria.LRTIs at≤2 years were associated with an increased risk of subsequent asthma up to 20 years[odds ratio(OR)=5.0,95%CI:3.3-7.5],with doctor-diagnosed asthma(OR=5.3,95%CI:3.3-8.6),current asthma(OR=5.4,95%CI:2.7-10.6),and current medication for asthma(OR=1.2,95%CI:0.7-3.9).Our overall estimates were not affected by publication bias(P=0.671),but there was significant heterogeneity[I 2=58.8%(30.6-75.5)].Compared to studies with hospitalized controls without LRTI,those with ambulatory controls had a significantly higher strength of association between LRTIs and subsequent asthma.The strength of the association between LRTIs and later asthma varied significantly by country and age at the time of the interview.The sensitivity analyses including only studies with similar proportions of confounding factors(gender,age at LRTI development,age at interview,gestational age,birth weight,weight,height,smoking exposure,crowding,family history of atopy,and family history of asthma)between cases and controls did not alter the overall estimates.CONCLUSION Regardless of the causative virus and confounding factors,viral LRTIs in children<2 years are associated with an increased risk of developing a subsequent asthma.Parents and pediatricians should be informed of this risk. | Sebastien Kenmoe Etienne Atenguena Okobalemba Guy Roussel Takuissu Jean Thierry Ebogo-Belobo Martin Gael Oyono Jeannette Nina Magoudjou-Pekam Ginette Irma Kame-Ngasse Jean Bosco Taya-Fokou Chris Andre Mbongue Mikangue Raoul Kenfack-Momo Donatien Serge Mbaga Arnol Bowo-Ngandji Cyprien Kengne-Ndé Seraphine Nkie Esemu Richard Njouom Lucy Ndip | 2022 | World Journal of Critical Care Medicine2022，11，4： | 3 |
| 2 | Changes in serum proealeitonin, interleukin 6, interleukin 8 and creactive protein in neonates after surgery显示文摘 | PAVCNIK ARNOL M BONAC B GROSEL GRENC M | 2010 | Eur J Pediatr Surg2010，20，4： | 1 |
| 3 | Rationale, design and baseline char- acteristics of a large, simple, randomized trial of combined folic acid and vitamins B6 and BI: in high-risk patients: the Heart Outcomes Prevention Evaluation( HOPE ) -2 trial 显示文摘 | Lonn E Held C Arnol JM | 2006 | Can J Cardiol2006，22，1： | 1 |
| 4 | Misleading hepatitis B test result due to intravenous immuno-globulin administration:implications for a clinical trial of rituximab in immune thrombocytopenia显示文摘 | DONALD M ARNOL D MARK A | 2010 | Trans fusion2010，50，： | 1 |
| 5 | Subclinical left ventricular echocardiographic abnormalities 1 year after kidney transplantation are associated with graft function and future cardiovascular events显示文摘 | Arnol M Knap B Oblak M | | 0，，10： | 1 |
| 6 | Neutrophil and monocyte CD64 indexes, lipopoly - saccharide -binding protein, procalcitonin and C - reactive protein in sepsis of critically ill neonates and children 显示文摘 | Groselj - Grenc M Ihan A Pavcnik - Arnol M | 2009 | Intensive Care Med2009，35，7： | 1 |
| 7 | Effective immunoprophylaxis with basiliximab plus triple therapy in renal transplantation:five-year single-center experience显示文摘 | Kandus A Grego K Arnol M | 2006 | Transplant Proc2006，38，： | 1 |
| 8 | Neutrophil and monoeyte CD64 indexes, lipopolysaceharide-binding protein, proealcitonin and C-reactive protein in sepsis of critically ill neonates and children显示文摘 | Groselj Grene M Ihan A Pavenik Arnol M | 2009 | Intensive Care Med2009，35，11： | 1 |
| 9 | Fungal endophytes:diversity and functional roles显示文摘 | Rodriguez RJ White JJ Arnole AE | | 0，，2： | 1 |
| 10 | Filtration of green algae and cyanobacteria by Nile tilapia (Oreochromis niloticus), in the Partitioned Aquaculture System 显示文摘 | HAKAN T ARNOL G E DAVID E B | 2003 | Aquaculture2003，215，10： | 1 |
| 11 | Phase diagram of the aluminium-silicon-iron system in the concentration range of 10%-14% Si and 0-3% Fe 显示文摘 | ZAKHAROV A M GU'DIN I T ARNOL'D A A MATSENKO Y A | 1988 | Russ Metall1988，3，： | 1 |
| 12 | Global prevalence of hepatitis B virus serological markers among healthcare workers:A systematic review and meta-analysis显示文摘BACKGROUND The hepatitis B virus(HBV)infection is a global public health concern that affects about 2 billion people and causes 1 million people deaths yearly.HBV is a bloodborne disease and healthcare workers(HCWs)are a high-risk group because of occupational hazard to patients’blood.Different regions of the world show a highly variable proportion of HCWs infected and/or immunized against HBV.Global data on serologic markers of HBV infection and immunization in HCWs are very important to improve strategies for HBV control.AIM To determine the worldwide prevalence of HBV serological markers among HCWs.METHODS In this systematic review and meta–analyses,we searched PubMed and Excerpta Medica Database(Embase)to identify studies published between 1970 and 2019 on the prevalence of HBV serological markers in HCWs worldwide.We also manually searched for references of relevant articles.Four independent investigators selected studies and included those on the prevalence of each of the HBV serological markers including hepatitis B surface antigen(HBsAg),hepatitis e antigen(HBeAg),immunoglobulin M anti-HBc,and anti-HBs.Methodological quality of eligible studies was assessed and random-effect model meta-analysis resulted in the pooled prevalence of HBV serological markers HBV infection in HCWs.Heterogeneity(I²)was assessed using theχ²test on Cochran’s Q statistic and H parameters.Heterogeneity’sources were explored through subgroup and metaregression analyses.This study is registered with PROSPERO,number CRD42019137144.RESULTS We reviewed 14059 references,out of which 227 studies corresponding to 448 prevalence data among HCWs(224936 HCWs recruited from 1964 to 2019 in 71 countries)were included in this meta-analysis.The pooled seroprevalences of current HBsAg,current HBeAg,and acute HBV infection among HCWs were 2.3%[95% confidence interval(CI):1.9-2.7],0.2%(95%CI:0.0-1.7),and 5.3%(95%CI:1.4-11.2),respectively.The pooled seroprevalences of total immunity against HBV and immunity acquired by natural HBV infection in HCWs were 56.6%(95%CI:48.7-63.4)and 9.2%(95%CI:6.8-11.8),respectively.HBV infection was more prevalent in HCWs in low-income countries,particularly in Africa.The highest immunization rates against HBV in HCWs were recorded in urban areas and in high-income countries including Europe,the Eastern Mediterranean and the Western Pacific.CONCLUSION New strategies are needed to improve awareness,training,screening,vaccination,post-exposure management and treatment of HBV infection in HCWs,and particularly in low-income regions. | Gadji Mahamat Sebastien Kenmoe Etheline W Akazong Jean Thierry Ebogo-Belobo Donatien Serge Mbaga Arnol Bowo-Ngandji Joseph Rodrigue Foe-Essomba Marie Amougou-Atsama Chavely Gwladys Monamele Chris Andre Mbongue Mikangue Ginette Irma Kame-Ngasse Jeannette Nina Magoudjou-Pekam Cromwel Zemnou-Tepap Dowbiss Meta-Djomsi Martin Maidadi-Foudi Sabine Aimee Touangnou-Chamda Audrey Gaelle Daha-Tchoffo Abdel Aziz Selly-Ngaloumo Rachel Audrey Nayang-Mundo Jacqueline Felicite Yengue Jean Bosco Taya-Fokou Lorraine K M Fokou Raoul Kenfack-Momo Dimitri Tchami Ngongang Efietngab Atembeh Noura Herve Raoul Tazokong Cynthia Paola Demeni Emoh Cyprien Kengne-Nde Jean Joel Bigna Onana Boyomo Richard Njouom | 2021 | World Journal of Hepatology2021，13，9： | 1 |
| 13 | Rationale design and baseline char-acteristics ofa large,simple,randomized trial of combined folic acid and vitamins B6 and B12 in high-risk patients:the Heart Outcomes Prevention Evaluation (HOPE)-2 trial显示文摘 | Lonn E Held C Arnol JM | 2006 | Can J Cardiol2006，22，1： | 1 |
| 14 | Lipopolysaccharide binding protein in critically ill neonates and children with suspected infection: comparison with procalcitonin, interleukin-6, and C-reactive protein显示文摘 | Pavcnik Arnol M Hojker S Derganc M | 2004 | Intensive Care Med2004，30，7： | 1 |
| 15 | Tracing quartz through the environment显示文摘 | Lal D Arnole J R | 1985 | Journal of Earth System Science1985，94，1： | 1 |
| 16 | Loss of stability of self-oscillations close to resonance and versal deformations of equivariant vector fields显示文摘 | V. I. Arnol’d | 1977 | Functional Analysis and Its Applications1977，，2： | 1 |
| 17 | Basiliximab versus daclizumab combined with triple immunosuppression in deceased donor renal, transplantatian: a prospective, randomized study 显示文摘 | KANDUS A ARNOL M OMAHEN K | 2010 | Transplantation2010，2789，8： | 1 |
| 18 | Intermittent high-volume predilution on-line haemofiltration versus standard intermittent haemodialysis in critically ill patients with acute kidney injury:a prospective randomized study显示文摘 | Skofic N Arnol M Bututovie-Ponikvar J | 2012 | Nephrol Dial Transplant2012，27，12： | 1 |
| 19 | Phase equilibria in the aluminum-silicon -iron- manganese system in the concentration range of 10%-14% silicon, 0-3% iron, and 0-4% manganese显示文摘 | Gul'din 1 T Arnol'd A A | 1988 | Izv Vyssh Zaved Tsvetn Metall1988，4，： | 1 |
| 20 | Phase diagram of the Al-Si-Fe-Mn system in the 10%-14% Si, 03% Fe, and 0-4% Mn concentration ranges显示文摘 | Gul′din I T Arnol′d A A | 1989 | Russ Metall1989，4，： | 1 |
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