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| 1 | Mesenchymal stromal cells-exosomes:a promising cell-free therapeutic tool for wound healing and cutaneous regeneration显示文摘Cutaneous regeneration at the wound site involves several intricate and dynamic processes which require a series of coordinated interactions implicating various cell types,growth factors,extracellular matrix(ECM),nerves,and blood vessels.Mesenchymal stromal cells(MSCs)take part in all the skin wound healing stages playing active and beneficial roles in animal models and humans.Exosomes,which are among the key products MSCs release,mimic the effects of parental MSCs.They can shuttle various effector proteins,messenger RNA(mRNA)and microRNAs(miRNAs)to modulate the activity of recipient cells,playing important roles in wound healing.Moreover,using exosomes avoids many risks associated with cell transplantation.Therefore,as a novel type of cell-free therapy,MSC-exosome-mediated administration may be safer and more efficient than whole cell.In this review,we provide a comprehensive understanding of the latest studies and observations on the role of MSC-exosome therapy in wound healing and cutaneous regeneration.In addition,we address the hypothesis of MSCs microenvironment extracellular vesicles(MSCs-MEVs)or MSCs microenvironment exosomes(MSCs-MExos)that need to take stock of and solved urgently in the related research about MSC-exosomes therapeutic applications.This review can inspire investigators to explore new research directions of MSC-exosome therapy in cutaneous repair and regeneration. | Peng Hu Qinxin Yang Qi Wang Chenshuo Shi Dali Wang Ubaldo Armato Ilaria Dal Prà Anna Chiarini | 2019 | Burns & Trauma2019，7，1： | 20 |
| 2 | Antagonizing amyloid-β/calcium-sensing receptor signaling in human astrocytes and neurons: a key to halt Alzheimer's disease progression?显示文摘Astrocytes' roles in late-onset Alzheimer's disease(LOAD) promotion are important, since they survive soluble or fibrillar amyloid-β peptides(Aβs) neurotoxic effects, undergo alterations of intracellular and intercellular Ca2+ signaling and gliotransmitters release via the Aβ/α7-n ACh R(α7-nicotinic acetylcholine receptor) signaling, and overproduce/oversecrete newly synthesized Aβ42 oligomers, NO, and VEGF-A via the Aβ/Ca SR(calcium-sensing receptor) signaling. Recently, it was suggested that the NMDAR(N-methyl-D-aspartate receptor) inhibitor nitromemantine would block the synapse-destroying effects of Aβ/α7-n ACh R signaling. Yet, this and the progressive extracellular accrual and spreading of Aβ42 oligomers would be stopped well upstream by NPS 2143, an allosteric Ca SR antagonist(calcilytic). | Ilaria Dal Prà Anna Chiarini Ubaldo Armato | 2015 | Neural Regeneration Research2015，10，2： | 6 |
| 3 | Massive training artificial neural network (MTANN) for reduction of false positives in computerized detection of lung nodules in low-dose computed tomography显示文摘 | SUZUKI K ARMATO S G LI F | 2003 | Med Phys2003，30，7： | 1 |
| 4 | Vessel tree reconstruction in thoracic CT scans with application to nodule detection显示文摘 | AGAM G ARMATO S G WU C | 2005 | IEEE Transactions on Medical Imaging2005，24，4： | 1 |
| 5 | Automated lung nodule classification following automated nodule detection on CT:A serial ap-proach 显示文摘 | Armato III S G Altman M B Wilkie J | 2003 | Medical Physics2003，30，6： | 1 |
| 6 | Automated detection of lung nodules in CT scans:False-positive reduction with the radial-gradient index 显示文摘 | Roy A S Armato III S G Wilson A | 2006 | Medical Physics2006，33，4： | 1 |
| 7 | CalCalciumsensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25-35 in human cortical astrocytes and neurons-Therapeutic relevance to Alzheimer' s d显示文摘 | Armato U Chiarini A Chakravarthy B | | 0，，10： | 1 |
| 8 | Lung im- age database consortium-developing a resource for the medical imaging research community 显示文摘 | Samuel G Armato Ill Geoffrey Mclennan | 2004 | Radiology2004，232，3： | 1 |
| 9 | Lung image database consortium: Developing a resource for the medical imaging research community 显示文摘 | ARMATO S G MCLENNAN G MCNITT-GRAY M F | 2004 | Radiology2004，232，3： | 1 |
| 10 | Automated lung segmention for thoracic CT:impact on computer-aided diagnosis显示文摘 | Armato S G Sensakovic W F | 2004 | Academic Radiology2004，11，9： | 1 |
| 11 | Myoepithelioma of a minor salivary gland of the cheek:case report显示文摘 | Ferri E Pavon I Armato E | 2006 | Acta Otorhinolaryngol Ital2006，26，1： | 1 |
| 12 | Focus harmonic scalpel compared to conventional haemostasis in open total thyroidectomy: A prospective randomized trial 显示文摘 | Ferri E Armato E Spinato G | 2011 | Int J Otolaryngol2011，2011，： | 1 |
| 13 | Assessment of radiologist performance in the detection of lung nodules 显示文摘 | Armato S G Roberts R Y Kocherginsky M Aberle D R Kazerooni E A MacMahon H | 2009 | Academic Radiology2009，16，1： | 1 |
| 14 | Automatedlung segmention For thoracic CT:impact on computer-aided diagnosis显示文摘 | Armato Samuel G Sensakovic William F | 2004 | Academic Radiology2004，11，9： | 1 |
| 15 | Bc110 crucially nucleates the pro-apoptotic complexes comprising PDK1, PKCζ and caspase-3 at the nuclear envelope of etoposide-treated human cervical carcinoma C4-I cells显示文摘 | Chiarini A Liu D Armato U | 2015 | Int J Mol Med2015，36，3： | 1 |
| 16 | Computerized detection of pulmonary nodules on CT scans显示文摘 | ARMATO A G GIGER M L MORAN C | 2000 | Radiographics2000，19，5： | 1 |
| 17 | Vessel tree reconstruction in thorac-ic CT scans with application to nodule detection 显示文摘 | Agam G Armato III S G Wu C H | 2005 | IEEE Trans Medical Imaging2005，24，4： | 1 |
| 18 | Lung texture in serial thoracic computed tomography scans:correlation of radiomics-based features with radiation therapy dose and radiation pneumonitis development显示文摘 | Cunliffe A Armato SG Castillo R | 2015 | Int J Radiat Oncol Biol Phys2015，91，5： | 1 |
| 19 | Carci-nosarcoma of the larynx:immunohistochemical study,clinical considerations,therapeutic strategies 显示文摘 | IANNIELLO F FERRI E ARMATO E | 2001 | ActaOtorhinolaryngol Ital2001，21，： | 1 |
| 20 | Lung image database consortium developing a resource for the medical imaging research community显示文摘 | Armato S G McLennan G | 2004 | Radiology2004，232，： | 1 |
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