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| 1 | Mesenchymal stromal cells-exosomes:a promising cell-free therapeutic tool for wound healing and cutaneous regeneration显示文摘Cutaneous regeneration at the wound site involves several intricate and dynamic processes which require a series of coordinated interactions implicating various cell types,growth factors,extracellular matrix(ECM),nerves,and blood vessels.Mesenchymal stromal cells(MSCs)take part in all the skin wound healing stages playing active and beneficial roles in animal models and humans.Exosomes,which are among the key products MSCs release,mimic the effects of parental MSCs.They can shuttle various effector proteins,messenger RNA(mRNA)and microRNAs(miRNAs)to modulate the activity of recipient cells,playing important roles in wound healing.Moreover,using exosomes avoids many risks associated with cell transplantation.Therefore,as a novel type of cell-free therapy,MSC-exosome-mediated administration may be safer and more efficient than whole cell.In this review,we provide a comprehensive understanding of the latest studies and observations on the role of MSC-exosome therapy in wound healing and cutaneous regeneration.In addition,we address the hypothesis of MSCs microenvironment extracellular vesicles(MSCs-MEVs)or MSCs microenvironment exosomes(MSCs-MExos)that need to take stock of and solved urgently in the related research about MSC-exosomes therapeutic applications.This review can inspire investigators to explore new research directions of MSC-exosome therapy in cutaneous repair and regeneration. | Peng Hu Qinxin Yang Qi Wang Chenshuo Shi Dali Wang Ubaldo Armato Ilaria Dal Prà Anna Chiarini | 2019 | Burns & Trauma2019，7，1： | 20 |
| 2 | Antagonizing amyloid-β/calcium-sensing receptor signaling in human astrocytes and neurons: a key to halt Alzheimer's disease progression?显示文摘Astrocytes' roles in late-onset Alzheimer's disease(LOAD) promotion are important, since they survive soluble or fibrillar amyloid-β peptides(Aβs) neurotoxic effects, undergo alterations of intracellular and intercellular Ca2+ signaling and gliotransmitters release via the Aβ/α7-n ACh R(α7-nicotinic acetylcholine receptor) signaling, and overproduce/oversecrete newly synthesized Aβ42 oligomers, NO, and VEGF-A via the Aβ/Ca SR(calcium-sensing receptor) signaling. Recently, it was suggested that the NMDAR(N-methyl-D-aspartate receptor) inhibitor nitromemantine would block the synapse-destroying effects of Aβ/α7-n ACh R signaling. Yet, this and the progressive extracellular accrual and spreading of Aβ42 oligomers would be stopped well upstream by NPS 2143, an allosteric Ca SR antagonist(calcilytic). | Ilaria Dal Prà Anna Chiarini Ubaldo Armato | 2015 | Neural Regeneration Research2015，10，2： | 6 |
| 3 | Effects of probiotic bacteria on gastrointestinal motility in guinea-pig isolated tissue显示文摘AIM: To evaluate the intestinal motility changes evoked by 8 bacterial strains belonging to Bifidobacterium , Lactobacillus and Streptococcus genera within the probiotic preparation VSL#3. METHODS: Ileum and proximal colon segments isolated from guinea-pigs were used as a study model. Entire cells and cell fractions (cell debris, cell wall fraction, cytoplasmatic fraction, proteinaceous and non- proteinaceous cytoplasmatic components) of VSL#3 strains and, as controls, Escherichia coli, Salmonella aboni and Bacillus licheniformis were tested in this in vitro model. RESULTS: Among the bacterial cell fractions tested, only the cytoplasmatic fraction modified intestinal motility. Lactobacillus strains stimulated the contraction of ileum segment, whereas all probiotic strains tested induced proximal colon relaxation response. The non-proteinaceous cytoplasmatic components were responsible for the colon relaxation. CONCLUSION: The results obtained in this study suggest that the proximal colon relaxation activity showed by the probiotic bacteria could be one of the possible mechanisms of action by which probiotics exert their positive effects in regulating intestinal motility. | Matteo Massi Pierfranco Ioan Roberta Budriesi Alberto Chiarini Beatrice Vitali Karen M Lammers Paolo Gionchetti Massimo Campieri Anthony Lembo Patrizia Brigidi | 2006 | World Journal of Gastroenterology2006，12，37： | 3 |
| 4 | Novel dermoepidermal equivalents on silk fibroin-based formic acid-crosslinked three-di- mensional non-woven devices withprospective applications in hu- man tissue engineering / regeneration / repair显示文摘 | Dal Pra I Chiarini A Boschi A | 2006 | Int J'' Mol Med2006，18，2： | 1 |
| 5 | Roles of Ca2 + and the Ca2+-sensing receptor (CASR) in the expression of inducible NOS (nitric oxide synthase)-2 and its BH4 (tetrahydrobiopterin)-dependent activation in cytokine-stimulated adult human astrocytes显示文摘 | Dal Pra I Chiarini A Nemeth EF | | 0，，02： | 1 |
| 6 | The phosphatidynositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients 显示文摘 | Martelli AM Evangelisti C Chiarini F | 2010 | Oncotarget2010，1，2： | 1 |
| 7 | CalCalciumsensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25-35 in human cortical astrocytes and neurons-Therapeutic relevance to Alzheimer' s d显示文摘 | Armato U Chiarini A Chakravarthy B | | 0，，10： | 1 |
| 8 | The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients 显示文摘 | Martelli AM Evangelisti C Chiarini F | 2010 | Oncotarget2010，1，2： | 1 |
| 9 | Tne phosphatidylinosi tol 3-kinase/Akt/mTOR signaling network as a therapeutic target inacute myelogenous leukemia patients显示文摘 | Martelli AM Evangelisti C Chiarini F | 2010 | Oncotar2010，6，1： | 1 |
| 10 | Novel dermo--epidermal equivalents on silk fibroin-based formic acid-crosslinked three-di- mensional non-woven devices withprospective applications in hu- man tissue engineering / regeneration / repair显示文摘 | Dal Pra I Chiarini A Boschi A | 2006 | Int J [Viol Med2006，18，2： | 1 |
| 11 | Current treatment strate- gies for inhibiting mTOR in cancer显示文摘 | Chiarini F Evangelisti C McCubrey JA | 2015 | Trends Pharmacol Sci2015，36，2： | 1 |
| 12 | Influence of plant development cultivar and soil type on microbial colonization of maize root显示文摘 | CHIARINI L BEVIVINO A DALMASTRI C | 1998 | Soil Ecol1998，8，： | 1 |
| 13 | De Novo Engineering ofReticular Connective Tissue In Vivo by Silk Fibroin Nonwoven Ma-terials 显示文摘 | Dal Pra I Freddi G Chiarini A | 2005 | Biomaterials2005，26，14： | 1 |
| 14 | Cytoplasmic c-Jun N-terminal immunoreactivity: a hallmark of retinal apoptosis显示文摘 | Chiarini LB de Freitas FG Leal-Ferreira ML | 2002 | Cell Mol Neurobiol2002，22，56： | 1 |
| 15 | Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells显示文摘 | Papa V Tazzari PL Chiarini F | | 0，，1： | 1 |
| 16 | Novel dermo-epidermal equiva- lents on silk fibroin-based formic acid-crosslinked three-dimensional non-woven devices withprospective applications in human tissue engi- neering regeneration epair 显示文摘 | Dal Pra I Chiarini A Boschi A | 2006 | lntMol Meal2006，18，2： | 1 |
| 17 | The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug- resistant human T-acute leukemia ceils by a JNK-dependent mechanism 显示文摘 | Chiarini F Del Sole M Mongiorgi S | 2008 | Leukemia2008，22，6： | 1 |
| 18 | Cellular prion protein transduces neuroprotective signals显示文摘 | Chiarini LB Freitas AR Zanata SM | 2002 | EMBO J2002，21，13： | 1 |
| 19 | Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment显示文摘 | Martelli AM Chiarini F Evangelisti Cv | 2012 | Oncotarget2012，3，4： | 1 |
| 20 | Toxicity of antimony trioxide nanoparticles on human hematopoietic progenitor cells and comparison to cell lines 显示文摘 | Bregoli L Chiarini F Gambarelli A | 2009 | Toxicology2009，262，2： | 1 |
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