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| 1 | Selective sphincteroplasty of the papilla in cases at risk due to atypical anatomy显示文摘AIM: To analyze the indications, effi cacy and safety of sphincteroplasty in our centre. METHODS: A retrospective study of sphincteroplasty in 53 cases of papilla at high risk was performed in 2004-2006. The procedure consisted of duodenoscopy with Olympus TJF 145 Videoduodenoscope, approach to the biliary tract using a catheter with a guidewire, and dilatation of the papilla with a dilatation balloon catheter using a syringe with a manometer for control of the fi lling pressure. RESULTS: The indications included intradiverticular papilla in 26 patients (49/), stenosis of a previous sphincterotomy in 19 patients (35.8/), small size of the papilla in 4 patients (7.5/), Billroth Ⅱ gastrectomy in 3 patients (5.6/), and coagulopathy in one patient (1.9/). The efficacy was 97.8/, with all the calculi extracted from the common bile duct in 84.4/ of the patients, even though 21 of the patients (39.6/) had calculi with a diameter equal to or greater than 10 mm. Seven patients (13.2/) presented complications: haemorrhage in 1 patient (1.9/) and mild pancreatitis in 6 patients (11.3/). The mean hospital stay in case of complications was of 3 ± 0.63 d. CONCLUSION: Sphincteroplasty is highly effective, with a complication rate similar to that of sphincterotomy, furthermore, the complications are of low clinical importance. The use of the 10 mm balloon makes it possible to extract calculi with a diameter of over 15 mm and to extract more than 3 calculi without increasing the rate of complications and reduces the need to resort tolithotripsy or rescue sphincterotomy. | F Mugica G Urdapilleta A Castiella A Berbiela F Alzate E Zapata L Zubiaurre P Lopez JI Arenas | 2007 | World Journal of Gastroenterology2007，13，22： | 5 |
| 2 | Translational pancreatic cancer research:a comparative study on patient-derived xenograft models显示文摘AIM To assess the viability of orthotopic and heterotopic patient-derived pancreatic cancer xenografts implanted into nude mice.METHODS This study presents a prospective experimental analytical follow-up of the development of tumours in mice upon implantation of human pancreatic adenocarcinoma samples. Specimens were obtained surgically from patients with a pathological diagnosis of pancreatic adenocarcinoma. Tumour samples from pancreatic cancer patients were transplanted into nude mice in three different locations(intraperitoneal, subcutaneous and pancreatic). Histological analysis(haematoxylin-eosin and Masson's trichrome staining) and immunohistochemical assessment of apoptosis(TUNEL), proliferation(Ki-67), angiogenesis(CD31) and fibrogenesis(α-SMA) were performed. When a tumour xenograft reached the target size, it was reimplanted in a new nude mouse. Three sequential tumour xenograft generations were generated(F1, F2 and F3).RESULTS The overall tumour engraftment rate was 61.1%. The subcutaneous model was most effective in terms of tissue growth(69.9%), followed by intraperitoneal(57.6%) and pancreatic(55%) models. Tumour development was faster in the subcutaneous model(17.7 ± 2.6 wk) compared with the pancreatic(23.1 ± 2.3 wk) and intraperitoneal(25.0 ± 2.7 wk) models(P = 0.064). There was a progressive increase in the tumour engraftment rate over successive generations for all three models(F1 28.1% vs F2 71.4% vs F3 80.9%, P < 0.001). There were no significant differences in tumour xenograft differentiation and cell proliferation between human samples and the three experimental models among the sequential generations of tumour xenografts. However, a progressive decrease in fibrosis, fibrogenesis, tumour vascularisation and apoptosis was observed in the three experimental models compared with the human samples. All three pancreatic patient-derived xenograft models presented similar histological and immunohistochemical characteristics.CONCLUSION In our experience, the faster development andgreatest number of viable xenografts could make the subcutaneous model the best option for experimentation in pancreatic cancer. | Mercedes Rubio-Manzanares Dorado Luis Miguel Marín Gómez Daniel Aparicio Sánchez Sheila Pereira Arenas Juan Manuel Praena-Fernández Juan Jose Borrero Martín Francisco Farfán López Miguel ángel Gómez Bravo Jordi Muntané Relat Javier Padillo Ruiz | 2018 | World Journal of Gastroenterology2018，24，7： | 2 |
| 3 | Synthesis of new calixcrowns and their anchoring to silica gel for the selective separation of Cs+ and K+显示文摘 | Arena G Casnati A Contino A | | 0，，： | 2 |
| 4 | Laparoscopic versus open resection for colorectal cancer;a metaanalysis of oncologlc outcomes显示文摘 | Jackson TD Kaplan GG Arena G | | 0，，： | 1 |
| 5 | Enterohepatie bacterial infections dysregulate the FGF15-FGFR4 endocrine axis 显示文摘 | Romain G Tremblay S Arena ET | 2013 | BMC Mierobiol2013，13，： | 1 |
| 6 | Frontline chemotherapy with bortezomib - containing combinations improves response rate and survival in primary plasma cell leukemia: a retrospective study from GIMEMA Multiple Myeloma Working Party显示文摘 | D'Arena G Valentini CG Pietrantuono G | 2012 | Ann Oneol2012，23，6： | 1 |
| 7 | Dedolomitization and other early diagenetic processes in Miocene lacustrine deposits, Ebro Basin (Spain) 显示文摘 | Arenas C Zarza A M A Pardo G | 1999 | Sed Geol1999，125，： | 1 |
| 8 | New chiral amino-phosphoramidite and bisphosphoramidite ligands derived from ( R, R)-1, 2-diaminocyclohexane: application in Cu-catalyzed asymmetric conjugate addition of diethylzinc to 2-cyclohexenone Tetrahedron显示文摘 | Carmela G Arena Vincenzo Casilli Felice Faraone | 2003 | Asymmetry2003，14，： | 1 |
| 9 | Flow cytometric characterization of human umbilical cord blood lymphocytes: immunophenotypic features 显示文摘 | D' Arena G Musto P Cascavilla N | 1998 | Haematologica1998，83，3： | 1 |
| 10 | Psycho-physiol- ogy of recurrent headache:methodolo-cal issues and new em- pirical findings显示文摘 | Andrasik F Blanchard EB Arena J G | 1982 | Behavior Therapy1982，13，4： | 1 |
| 11 | Laparoscopic versus open resection for colorectal cancer: a metaanalysis of oncologic outcomes显示文摘 | Jackson TD Kaplan GG Arena G | 2007 | J Am Coil Surg2007，204，3： | 1 |
| 12 | GSK-3beta inhibition/beta-catenin stabilization in ventral midbrain precursors increases differentiation into dopamine neurons显示文摘 | Castelo-Branco G Rawal N Arenas E | | 0，，24： | 1 |
| 13 | Frontline chemotherapy with bortezomib - containing combinations improves response rate and survival in primary plasma cell leukemia: a retrospective study from GIMEMA Multiple Myeloma Working Party显示文摘 | D'Arena G Valentini CG Pietrantuono G | 2012 | Ann Oncol2012，23，6： | 1 |
| 14 | Acoustic Impedance Matching of Piezoelectric Transducers to the Air显示文摘 | Arenas A | 2004 | IEEE Ultrasonics Ferroelectrics and Frequency control 51(5)2004，，： | 1 |
| 15 | Photovoltaic properties of multi-walled carbon nanotubes deposited on n-doped silicon 显示文摘 | Arena A Donato N Saitta G | 2008 | Microelectron J2008，39，12： | 1 |
| 16 | Catalytic features of Mg modified Ni/SiO2/silica cloth systems in the decomposition of methane for making'COx-free'H2显示文摘 | ltaliano G Espro C Arena F | 2008 | Catalysis Today2008，124，： | 1 |
| 17 | Health system costs of falls of older alduts in Western Australia显示文摘 | Hendrie D Hall SE Arena G | 2004 | Aust Health Rev2004，8，3： | 1 |
| 18 | Health system costs of falls of older adults in Western Australia显示文摘 | Hendrie D Hall SE Arena G | 2004 | Aust Health Rev2004，28，3： | 1 |
| 19 | Preoperative management and surgical therapy in complicated acute infective endocarditis: a 5-years experience显示文摘 | Arena V Gerometta PS Pompilio G | 1993 | Cardiovasc Surg1993，1，4： | 1 |
| 20 | Barley p-glucans-contai-ning food enhances probiotic performances of beneficial bacteria显示文摘 | Arena MP Caggianiello G Fiocco D | 2014 | Int J Mol Sci2014，15，2： | 1 |
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