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| 1 | Assessment of disease progression in patients with transfusion-associated chronic hepatitis C using transient elastography显示文摘AIM:To evaluate the relationship between liver stiffness and duration of infection in blood transfusion-associated hepatitis C virus (HCV) patients with or without hepatocellular carcinoma (HCC).METHODS:Between December 2006 and June 2008,a total of 524 transfusion-associated HCV-RNA positive patients with or without HCC were enrolled.Liver stiffness was obtained noninvasively by using Fibroscan (Echosens,Paris,France).The date of blood transfusion was obtained by interview.Duration of infection was derived from the interval between the date of bloodtransfusion and the date of liver stiffness measurement (LSM).Patients were stratified into four groups based on the duration of infection (17-29 years;30-39 years;40-49 years;and 50-70 years).The difference in liver stiffness between patients with and without HCC was assessed in each group.Multiple linear regression analysis was used to determine the factors associated with liver stiffness.RESULTS:A total of 524 patients underwent LSM.Eight patients were excluded because of unsuccessful measurements.Thus 516 patients were included in the current analysis (225 with HCC and 291 without).The patients were 244 men and 272 women,with a mean age of 67.8 ± 9.5 years.The median liver stiffness was 14.3 kPa (25.8 in HCC group and 7.6 in nonHCC group).The patients who developed HCC in short duration of infection were male dominant,having lower platelet count,with a history of heavier alcohol consumption,showing higher liver stiffness,and receiving blood transfusion at an old age.Liver stiffness was positively correlated with duration of infection in patients without HCC (r=0.132,P=0.024) but not in patients with HCC (r=-0.103,P=0.123).Liver stiffness was significantly higher in patients with HCC than in those without in each duration group (P < 0.0001).The factors significantly associated with high liver stiffness in multiple regression were age at blood transfusion (P < 0.0001),duration of infection (P=0.0015),and heavy alcohol consumption (P=0.043) CONCLUSION:Although liver stiffness gradually increases over time,HCC develops in patients with high stiffness value regardless of the duration of infection. | Ryota Masuzaki Ryosuke Tateishi Haruhiko Yoshida Toru Arano Koji Uchino Kenichiro Enooku Eriko Goto Hayato Nakagawa Yoshinari Asaoka Yuji Kondo Tadashi Goto Hitoshi Ikeda Shuichiro Shiina Masao Omata Kazuhiko Koike | 2012 | World Journal of Gastroenterology2012，18，12： | 4 |
| 2 | Cytological studies in suhfamily Carduoideae (Compositae) of Japan Ⅸ显示文摘 | Arano H | 1963 | Botanic Magazine1963，76，： | 1 |
| 3 | Cytological studies in subfamily carduoideae(compositae) of Japan IX 显示文摘 | Arano H | 1963 | Bot Mag1963，76，： | 1 |
| 4 | The karyotypes and the speciations in subfamily Car- duoideae (Compositae) of Japan XVIII 显示文摘 | Arano H 1965 | 1965 | Journal of Japa- nese Botany1965，19，1： | 1 |
| 5 | Malignant mixed Mullerian tumors 显示文摘 | RUIZ T J REGUEM CAUEJAS M E ARANO BER- MEJO J I | 2006 | Clin Transl Oncol2006，8，2： | 1 |
| 6 | R-Ras promotes tumor growth of cervical epithelial cells显示文摘 | Rincon Arano H Rosales R Mora N | 2003 | Cancer2003，97，3： | 1 |
| 7 | Radiofrequency ablation for hepatocellular carcinoma: lO-year outcome and prognostic factors 显示文摘 | Shiina S Tateishi R Arano T | 2012 | Am J Gastroenterol2012，107，4： | 1 |
| 8 | The karotypes and the speeiations in subfamily Carduoideae of Japan显示文摘 | Arano H | 1965 | Japanese Journal of Botany1965，19，3： | 1 |
| 9 | Cytological studies in subfamily Carduoideae(Compositae) of Japan 显示文摘 | ARANO H | 1963 | IX Bot Mag (Tokyo)1963，76，： | 1 |
| 10 | Cytilogical studies in subfamily earduoideae of Japan Ⅸ 显示文摘 | Arano H | 1963 | Bot Mag (Tokyo)1963，76，： | 1 |
| 11 | Cytological studies in Pertya, Ainsli- aea and Diaspanthus of tribe Mutisieae (Compositae) of Japan 显示文摘 | Arano H Nakamura T 1968 | 1968 | Botanical Magazine (Tokyo)1968，81，957： | 1 |
| 12 | Clinical im m unologicalim pact of early postoperative enteral im m unonutritionafter total gastrectom y in gastric cancer patients :A prospective random ized study 显示文摘 | M arano L Porfidia R Pezzella M etal | 2013 | A nn Surg O ncol2013，20，12： | 1 |
| 13 | The karotypes and the speciations in subfamily Carduoideae of Japan显示文摘 | Arano H | 1965 | Jap Journ Bot1965，19，3： | 1 |
| 14 | Gytological studies in subfamily Car-duoideae (Compositaeof Japan IX显示文摘 | Arano H | 1963 | BotMag (Toky-o)1963，，76： | 1 |
| 15 | ^99Tc^m-HYN-IC-derivatized ternary ligand complexes for ^99Tc^m-labeled polypeptides with low in vivo protein binding显示文摘 | Ono M Arano Y Mukai T | 2001 | Nucl Med Biol2001，28，3： | 1 |
| 16 | Detection of Experimental Autoimmune Myocarditis in Rats by 111In Monoclonal Antibody Specific for Tenascin-C显示文摘 | Mikio Sato Tetsuya Toyozaki Kenichi Odaka Tomoya Uehara Yasushi Arano Hiroshi Hasegawa Katsuya Yoshida Kyoko Imanaka-Yoshida Toshimichi Yoshida Michiaki Hiroe Hiroyuki Tadokoro Toshiaki Irie Shuji Tanada Issei Komuro | 2002 | Circulation: Journal of the American Heart Association2002，，： | 1 |
| 17 | Cytological studies in subfamily Carduoideae of Japan 显示文摘 | Arano H | 1963 | Bot Mag Tokyo1963，76，： | 1 |
| 18 | Control of radioactivity pharmacokinetics of ^99Tc^m-HYNIC-labeled polypeptides derivatized with ternary ligand complexes显示文摘 | Ono M Arano Y Mukai T | 2002 | Bioconjug Chem2002，13，3： | 1 |
| 19 | Intracellular metabolic fate of radioactivity after injection of technetiurn-99m-labeled hydrazino nicotinamide derivatized proteins显示文摘 | Ono M Arano Y Uehara T | 1999 | Bioconjug Chem1999，10，3： | 1 |
| 20 | The karyotypes and the speciations insubfamily Car- duoideae of Japan 显示文摘 | Arano H | 1965 | Jap Joum Bot1965，19，3： | 1 |
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