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| 1 | Protective effect of resveratrol against cadmium-induced toxicity on ovine oocyte in vitro maturation and fertilization显示文摘Background:Heavy metal cadmium(Cd)is a widespread environmental contaminant with a potential toxicity that might negatively affect female reproduction and fertility.It has been reported that Cd exposure impaired the quality of oocytes and led to a defective maturation and fertilization,through oxidative stress induction.Resveratrol(Res)is a natural polyphenol with strong antioxidant properties that exhibited protective role in preventing oocyte redox homeostasis disruption and quality decline.Here,we explored whether the addition of Res to in vitro maturation(IVM)medium might act as a protection against Cd-induced toxicity on ovine oocyte maturation and fertilization.Firstly,we evaluated the effect of supplementing IVM medium with two different Res concentrations(1and 2μmol/L)on nuclear maturation and fertilization of oocytes matured under CdCl2(2μmol/L)exposure.Therefore,the concentration of 1μmol/L Res was selected to analyse the effects of this compound on intracellular ROS levels,mitochondrial(mt)distribution and activity,chromatin configuration,cytoskeleton morphology,cortical granules(CGs)distribution and mRNA expression of genes associated with cellular response to oxidative stress(i.e.SIRT1,SOD 1,GPX1,GSR,CAT)in Cd-exposed in vitro matured oocytes.Results:We found that 1μmol/L Res restored the reduced oocyte meiotic competence induced by Cd exposure as well as,Res sustained oocyte ability to be normally fertilized and decreased polyspermic fertilization at both tested concentrations.Moreover,we demonstrated that 1μmol/L Res mitigated Cd-induced alterations of oocyte cytoplasmic maturation by reducing reactive oxygen species(ROS)accumulation,preventing mt dysfunction,maintaining the correct meiotic spindle and cortical F-actin assembly and the normal cortical granule distribution as well as up-regulating SIRT1,SOD1 and GPX1 genes.Conclusions:Taken together,our findings highlighted the beneficial influence exerted by Res in preventing Cdinduced disturbance of nuclear and cytoplasmic maturation and subsequent fertilization in ovine oocytes.Res treatment may help to establish defence strategies counteracting Cd-induced toxicity on the female gamete. | Anna Rita Piras Federica Ariu Alessio Maltana Giovanni Giuseppe Leoni Nicola Antonio Martino Antonella Mastrorocco Maria Elena Dell’Aquila Luisa Bogliolo | 2023 | Journal of Animal Science and Biotechnology2023，14，1： | 3 |
| 2 | Thermonuclear ^19F(p,α0)^16O reaction rate显示文摘The thermonuclear^(19)F(p,α_0)16O reaction rate in the temperature region 0.007–10 GK has been derived by re-evaluating the available experimental data, together with the low-energy theoretical R-matrix extrapolations.Our new rate deviates by up to about 30% compared to the previous results, although all rates are consistent within the uncertainties. At very low temperature(e.g. 0.01 GK) our reaction rate is about 20% lower than the most recently published rate, because of a difference in the low energy extrapolated S-factor and a more accurate estimate of the reduced mass used in the calculation of the reaction rate. At temperatures above ~1 GK, our rate is lower, for instance, by about 20% around 1.75 GK, because we have re-evaluated the previous data(Isoya et al., Nucl. Phys.7, 116(1958)) in a meticulous way. The present interpretation is supported by the direct experimental data. The uncertainties of the present evaluated rate are estimated to be about 20% in the temperature region below 0.2 GK,and are mainly caused by the lack of low-energy experimental data and the large uncertainties in the existing data.Asymptotic giant branch(AGB) stars evolve at temperatures below 0.2 GK, where the^(19)F(p,α)16O reaction may play a very important role. However, the current accuracy of the reaction rate is insufficient to help to describe, in a careful way, the fluorine over-abundances observed in AGB stars. Precise cross section(or S factor) data in the low energy region are therefore needed for astrophysical nucleosynthesis studies. | 何建军 Ivano Lombardo Daniele Dell’Aquila 徐毅 张立勇 柳卫平 | 2018 | Chinese Physics C2018，42，1： | 2 |
| 3 | Effects of irrigation with saline waters, at different concentrations, on soil physical and chemical characteristics显示文摘 | A. Tedeschi R. Dell’Aquila | 2005 | Agricultural Water Management2005，，1： | 2 |
| 4 | Toxic effects of the mycotoxin zearalenone and its derivatives on in vitro maturation of bovine oocytes and 17β-estradiol levels in mural granulosa cell cultures显示文摘 | F Minervini M.E Dell’Aquila F Maritato P Minoia A Visconti | 2001 | Toxicology in Vitro2001，，4： | 2 |
| 5 | 猪精子细胞中胰岛素诱导产生的一氧化氮自由基促进精子获能显示文摘近期,胰岛素被证实具有诱导猪精子获能的能力。在不同的哺乳动物中,精子获能被认为与一氧化氮信号通路相关;因此,本研究使用荧光激活细胞分选技术探究经胰岛素处理的猪精子中一氧化氮水平。在同一样本中,用金霉素染色、蛋白质酪氨酸磷酸化模式和顶体状态来评估精子获能。结果显示经胰岛素处理的精子内一氧化氮水平及三种评价精子获能的指标均有显著提高;相反,用一氧化氮合成酶抑制剂(N-硝基-L-精氨酸甲酯)或抗胰岛素受体β抗体预处理的精子中胰岛素相关的作用全被逆转。这些结果表明胰岛素具有增强猪精子细胞内一氧化氮浓聚的能力并且提示胰岛素可能通过一氧化氮促进精子获能。 | Saveria Aquila Francesca Giordano Carmela Guido Vittoria Rago Amalia Carpino | 2013 | Asian Journal of Andrology2013，15，6： | 2 |
| 6 | Stability improvements of an LCL-filter based three-phase active rectifier显示文摘 | Liserre M Dell'Aquila A Blaabjerg F | 2002 | Proceedngs of PESC2002，，3： | 1 |
| 7 | Design of H bridge multilevel active rectifier for traction systerns显示文摘 | Cecati C Dell'Aquila A Liserre M | 2003 | IEEE Trans- actions on Industry Applications2003，39，5： | 1 |
| 8 | Islanding detection method for single-phase distributed generation systems based on in- verters显示文摘 | LISERRE M PIGAZO A AQUILA A D | 2005 | IEEE2005，25，： | 1 |
| 9 | Adnexal gland secretion markers in unexplained asthenozoospermia显示文摘 | Carpino A Sisci D Aquila S | 1994 | Arch Androl1994，32，1： | 1 |
| 10 | SIRT3 gene expression: a link between inherited mitocbondrial DNA variants and oxidative stress显示文摘 | D'Aquila P Rose G Panno ML | 2012 | Gene2012，497，2： | 1 |
| 11 | Specific chromosome 1 breaks induced by human cytomegalovirus 显示文摘 | Fortunato EA Dell' Aquila ML Spector DH | 2000 | Proc Natl Acad Sci USA2000，97，2： | 1 |
| 12 | Genetic algorithm-based design of the active damping for an LCL-filter three-phase active rectifier显示文摘 | Liserre M Dell'Aquila A Blaabjerg F | 2004 | IEEE Transactions on Industry Applications2004，19，1： | 1 |
| 13 | The Vicenza 'Short' peritoneal catheter:a twenty year experience显示文摘 | Dell'Aquila R Chiaramonte S Rodighiero M P | | 0，，： | 1 |
| 14 | Antiretroviral drug resistance testing in adults with HIV infection显示文摘 | HirschMS Brun-Vezinet F D'aquila RT | 2000 | JAMA2000，283，： | 1 |
| 15 | Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells显示文摘 | Albanito L Sisci D Aquila S | 2008 | Endocrinology2008，149，8： | 1 |
| 16 | Ageing and osmotic prim- ing in wheat seeds: effects upon certain components of seed quality 显示文摘 | DELL AQUILA A TRITTO V | 1990 | Annals of Botany1990，65，1： | 1 |
| 17 | Facial pain : a possible therapy with stellate ganglion block 显示文摘 | Salvaggio I Adducci E Dell'Aquila L | 2008 | Pain Med2008，9，7： | 1 |
| 18 | Tissue microarray-based studies of patients with lymph node negative breast carcinoma show that met expression is associated with worse outcome but is not correlated with epidermal growth factor family receptors显示文摘 | Tolgay-Ocal I Dolled-Filhart M D'Aquila T G | 2003 | Cancer2003，97，8： | 1 |
| 19 | Meiotic competence of equine oocytes and pronucleus formation after intracytoplasmie sperm injection (ICSI) as related to granulosa cell apoptosis显示文摘 | Dell Aquila M E Albrizio M Maritato F | 2003 | Biol Reprod2003，68，6： | 1 |
| 20 | Atrypical drugs and long - term outcome in schizphrenia 显示文摘 | Weiden P Aquila R Standard J | 1996 | J Chin Psychiatry1996，57，11： | 1 |
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