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| 1 | Propylthiouracyl-induced severe liver toxicity:An indication for alanine aminotransferase monitoring?显示文摘Propylthiouracyl (PTU)-related liver toxicity is likely to oc- cur in about 1% of treated patients. In case of acute or subacute hepatitis, liver failure may occur in about one third. We report two further cases of PTU-induced sub- acute hepatitis, in whom the delay between occurrence of liver damage after the initiation of treatment, the un- derestimation of its severity and the delayed withdrawal of the drug were all likely responsible for liver failure. The high incidence of liver toxicity related to PTU, its potential severity and delayed occurrence after initiation of treatment are in favor of monthly alanine aminotrans- ferase monitoring, at least during the first six months of therapy. | M Benyounes C Sempoux C Daumerie J Rahier AP Geubel | 2006 | World Journal of Gastroenterology2006，12，38： | 3 |
| 2 | Diagnostic value of drain amylase for detecting intrathoracic leakage after esophagectomy显示文摘AIM:To investigate the value of elevated drain amylase concentrations for detecting anastomotic leakage(AL) after minimally invasive Ivor-Lewis esophagectomy(MIILE).METHODS:This was a retrospective analysis of prospectively collected data in two hospitals in the Netherlands. Consecutive patients undergoing MI-ILE were included. A Jackson-Pratt drain next to the dorsal side of the anastomosis and bilateral chest drains were placed at the end of the thoracoscopic procedure. Amylase levels in drain fluid were determined in all patients during at least the first four postoperative days. Contrast computed tomography scans and/or endoscopic imaging were performed in cases of a clinically suspected AL. Anastomotic leakage was defined as any sign of leakage of the esophago-gastric anastomosis on endoscopy,re-operation,radiographic investigations,post mortal examination or when gastro-intestinal contents were found in drain fluid. Receiver operator characteristic curves were used to determine the cut-off values. Sensitivity,specificity,positive predictive value,negative predictive value,risk ratio and overall test accuracy were calculated for elevated drain amylase concentrations.RESULTS:A t o t a l o f 8 9 p a t ie n t s w e re in c lu d e d between March 2013 and August 2014. No differences in group characteristics were observed between patients with and without AL,except for age. Patients with AL were older than were patients without AL(P = 0.01). One patient(1.1%) without AL died within 30 d after surgery due to pneumonia and acute respiratory distress syndrome. Anastomotic leakage that required any intervention occurred in 15 patients(16.9%). Patients with proven anastomotic leakage had higher drain amylase levels than patients without anastomotic leakage [median 384 IU/L(IQR 34-6263) vs median 37 IU/L(IQR 26-66),P = 0.003]. Optimal cut-off values on postoperative days 1,2,and 3 were 350 IU/L,200 IU/L and 160 IU/L,respectively. An elevated amylase level was found in 9 of the 15 patients with AL. Five of these 9 patients had early elevations of their amylase levels,with a median of 2 d(IQR 2-5) before signs and symptoms occurred.CONCLUSION:Measurement of drain amylase levels is an inexpensive and easy tool that may be used to screen for anastomotic leakage soon after MI-ILE. However,clinical validation of this marker is necessary. | Gijs HK Berkelmans Ewout A Kouwenhoven Boudewijn JJ Smeets Teus J Weijs Luis C Silva Corten Marc J van Det Grard AP Nieuwenhuijzen Misha DP Luyer | 2015 | World Journal of Gastroenterology2015，21，30： | 3 |
| 3 | Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carriers显示文摘 | Lindh M Hannoun C Dhillon AP | 1999 | J Infect Dis1999，179，4： | 2 |
| 4 | Spatial normalization of brain images with focal lesions using cost function masking 显示文摘 | Brett M Leff AP Rorden C | 2001 | Neuroimage2001，14，2： | 1 |
| 5 | Postcesarean fever and uterine rupture in a subsequent trial of labor显示文摘 | Shipp T Zelop C Cohen AP | 2001 | Am J Obstet Gynecol2001，184，2： | 1 |
| 6 | Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carriers显示文摘 | Lindh M Hannoun C Dhillon AP | 1999 | J Infect Dis1999，179，4： | 1 |
| 7 | Expression of pituitarytumor transforming gene in colorectal tumors 显示文摘 | Heaney AP Singson R McCabe C J | 2000 | Lancet2000，355，： | 1 |
| 8 | Quantitative analysis of Th1,Th2 and TGF-(1 cytokine expression in tumor,TIL and PBL of non-small cell lung cancer patients显示文摘 | Carine AP Hamid E Geraldine C | 1998 | Int J Cancer1998，77，1： | 1 |
| 9 | FGF23 induces left ventricular hypertrophy显示文摘 | Faul C Amaral AP Oskouei B | 2011 | J Clin Invest2011，121，11： | 1 |
| 10 | Tuberculosis deaths in a tertiary hospital in Goiania, Brazil: a descriptive study 显示文摘 | Tavares C Bacelar Acioli Lins T Junqueira Kipnis AP | 2013 | Infez Med2013，21，4： | 1 |
| 11 | Long-term effects of triptolide on spermatogenesis,epididymal sperm function and fertility in male rats显示文摘 | Huynh PN Hikim AP Wang C | | 0，，05： | 1 |
| 12 | Magnetic resonance imaging of ductal carcinoma in situ: what is its clinical application? A review 显示文摘 | Schouten van der Velden AP Schlooz-Vdes MS Boetes C | 2009 | Am J Surg2009，198，2： | 1 |
| 13 | NPY regulates catecholamine secretion from human adrenal chromaffin cells显示文摘 | Cavadas C Silva AP Mosimann F | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
| 14 | Identification of novel polymorphisms within the promoter region of the human β2 adrenergic receptor gene显示文摘 | Scott MG Swan C Wheatley AP | 1999 | Br J Pharmacol1999，126，： | 1 |
| 15 | Least limiting water range:A potential indicator of changes in near-surface soil physical quality afterthe conversion of Brazilian Savanna into pasture显示文摘 | LEO T P DA SILVA AP MACEDO M C M | 2006 | Soil&Tillage Re-search2006，88，： | 1 |
| 16 | NPY regulatcs catecholamine secretion from human adrenal chromaffin cells显示文摘 | Cavadas C Silva AP Mosimann F | | 0，，12： | 1 |
| 17 | Effect of rapid fluid resuscitation using crystalloids or colloids on hemostasis in piglets 显示文摘 | Mauch J Madjdpour C Kutter AP | 2013 | Paediatr Anaesth2013，23，3： | 1 |
| 18 | Assessment of the Urodynamic diagnosis in patients with urinary incontinence associated with normal pressure hydrocephalus 显示文摘 | Felix C Jose LG Jose AP | 2015 | Neurourol Urodyn2015，34，： | 1 |
| 19 | Myocardial dysfunction and neurohumoral activation without remodeling in left ventricle of monocrotalineinduced pulmonary hypertensive rats 显示文摘 | Loureno AP Roncon-Albuquerque R Jr Brfls-Silva C | 2006 | Am J Physiol He- art Cire Physiol2006，291，4： | 1 |
| 20 | A proposal for standardization in forensic canine DNA typing: allele nomenclature of six canine-specific STR loci 显示文摘 | Hellmann AP Rohleder U Eichmann C Pfeiffer I Parson W Schleenbecker U | 2006 | Journal of Forensic Science2006，51，： | 1 |
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