| 1 | Propylthiouracyl-induced severe liver toxicity:An indication for alanine aminotransferase monitoring?显示文摘Propylthiouracyl (PTU)-related liver toxicity is likely to oc- cur in about 1% of treated patients. In case of acute or subacute hepatitis, liver failure may occur in about one third. We report two further cases of PTU-induced sub- acute hepatitis, in whom the delay between occurrence of liver damage after the initiation of treatment, the un- derestimation of its severity and the delayed withdrawal of the drug were all likely responsible for liver failure. The high incidence of liver toxicity related to PTU, its potential severity and delayed occurrence after initiation of treatment are in favor of monthly alanine aminotrans- ferase monitoring, at least during the first six months of therapy. | M Benyounes C Sempoux C Daumerie J Rahier AP Geubel | 2006 | World Journal of Gastroenterology2006，12，38： | 3 |
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