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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Hemobilia as the initial manifestation of cholangiocarcinoma in a hemophilia B patient显示文摘Hemobilia is a rare manifestation of hemophilia and is usually iatrogenic following liver biopsy. There are only few reports of spontaneous hemobilia in hemophilia patients. Cholangiocarcinoma is a well-established cause of hemobilia. We describe a case of a 70-year-old male, with known haemophilia B and a past history of papillotomy, who presented with classical symptoms of hemobilia. The initial diagnostic work-up failed to demonstrate a potential cause of bleeding other than the coagulopathy. Three months later, he was readmitted to our hospital with a second episode of hemobilia. During the second work-up, a cholangiocarcinoma was diagnosed both by imaging studies and by a significant elevation of cancer antigen 19-9. Although hemobilia could be attributed to hemophilia, especially in a patient with previous papillotomy, an underlying malignancy of the biliary tree should be suspected. | Anastassios C Manolakis Andreas N Kapsoritakis Antonis D Tsikouras Fotis D Tsiopoulos Athanassios K Psychos Spyros P Potamianos | 2008 | World Journal of Gastroenterology2008，14，26： | 5 |
| 3 | 显示文摘 | Mathews T Manoravi P Antony M P | 2000 | Solid State Ionics2000，135，： | 1 |
| 4 | On the division of attention: A disproof of the single channel hypothesis显示文摘 | Allport D Antonis B Reynolds P | 1972 | Quarterly Journal of Experimental Psychology1972，24，： | 1 |
| 5 | Sythesis of L-and-D- methionine显示文摘 | Langstrom B Antoni G Gullberg P | 1987 | J Nucl Med1987，28，： | 1 |
| 6 | Large scale production and downstream processing of a recombinant porcine parvovirus vaccine显示文摘 | MARANGA L RUEDA P ANTONIS AFG | 2002 | Appl Microbiol Biotechnol2002，59，： | 1 |
| 7 | Minimal extracorporeal circulation circuit standby for 'off-pump' left ventricular assist device implantation显示文摘 | Anastasiadis K Westaby S Antonis P et at | 2010 | Artif Organs2010，34，12： | 1 |
| 8 | Corrosion of 2205 duplex stainless steel in chloride medium containing sulfatereducing bacteria 显示文摘 | ANTONY P J CHONGDAR S KUMAR P | 2007 | Eleetrochim Acta2007，52，12： | 1 |
| 9 | The effect of salt - phase composition on the rate of soda - ash roasting of chromite ores显示文摘 | Tathavadkar V D Antony M P Jha A | 2003 | Metallurgical and Materials Transactions B2003，34，5： | 1 |
| 10 | CD8 + T cell immunity a- gainst a tumor/self-antigen is augmented by CD4 + T helper cells and hindered by naturally occurring T regulatory cells 显示文摘 | Antony P A Piccirillo C A Akpinarli A | 2005 | J Immunol2005，174，： | 1 |
| 11 | A comprehensive Bayesian approach for model updating and quantification of modeling errors 显示文摘 | Zhang E L Feissel P Antoni J | 2011 | Probabilistic Engineering Me- chanics2011，26，4： | 1 |
| 12 | Predictive value of D-dimer plasma levels in response and progressive disease in patients with lung cancer显示文摘 | Antoniou D Pavlakou G Stathopoulos G P | 2006 | Lung Cancer2006，53，2： | 1 |
| 13 | Nanophase iron-enhanced chemical reactivity of ground lunar soil 显示文摘 | WILLIAM T W CRYSTAL J P ANTONY S J | 2010 | Earth and Planetary Science Letters2010，295，34： | 1 |
| 14 | Identification and prediction of discrete chaotic maps applying a Chebyshev neural network 显示文摘 | AKRITAS P ANTONIOU I IVANOV V V | 2000 | Chaos Solitons and Fractals2000，11，13： | 1 |
| 15 | Interleukin-2-dependent mechanisms of tolerance and immunity in vivo 显示文摘 | Antony P A Paulos C M Ahmadzadeh M | 2006 | J Immunol2006，176，： | 1 |
| 16 | Futures trading, information and spot price volatility: Evidence for the FTSE-100 stock index futures contract using GARCH显示文摘 | Antoniou A Holmes P | 1995 | Journal of Banking and Finance1995，19，1： | 1 |
| 17 | Failureprediction for a glass/epoxy cruciorm specimen under static biaxial loading 显示文摘 | Antoniou A E van Hemelrijck D Philippidis T P | 2010 | Composites Science and Technology2010，70，8： | 1 |
| 18 | The BOADICEA model of genetic susceptibility to breas and ovarian cancer显示文摘 | Antoniou AC Pharoah PP Smith P | 2004 | Br J Cancer2004，91，8： | 1 |
| 19 | Effect of temperature and pH on the effective maximum specific growth rate of nitrifying bacteria 显示文摘 | ANTONIOU P HAMILTON J KOOPMAN B | 1990 | Water Research1990，24，1： | 1 |
| 20 | Large scale production and downstream processing of a recombinant porcine parvovirus vaccine显示文摘 | Maranga L Rueda P Antonis AFG | 2002 | Appl Microbiol Biotechnol2002，59，： | 1 |
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