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| 1 | Periodic atomization characteristics of simplex swirl injector induced by klystron effect显示文摘The atomization dynamic characteristics of a simplex swirl injector was investigated experimentally by using a hydrodynamic mechanical pulsator and the shadow photography technique. The frequency response characteristics of the fluid film and atomization fluctuations and their correlations with pressure fluctuations were obtained by using an in-house code of image processing. It is demonstrated that the klystron effect induced by periodic pressure fluctuations results in periodic liquid film fluctuation with large amplitudes, periodic superposition of droplets and reduction of the breakup length. It was found that the atomization of the simplex swirl injector only responds to the pressure fluctuation in frequency range approximately from 0 to 300 Hz, and it is particularly sensitive to pressure fluctuations at frequencies from 100 to 200 Hz. According to this experiment, the responsive frequency limitation is merely affected by injector configuration, rather than the supply line. | Anlong YANG Shangrong YANG Yunfei XU Longfei LI | 2018 | Chinese Journal of Aeronautics2018，31，5： | 8 |
| 2 | Polymorphisms of chemokine receptors and its ligand alleles influencing genetic suscepti-bity to HIV-1 infection in eight ethnic groups in Chinese mainland显示文摘Limited genetic information is available concerning the polymorphisms of HIV-1 resistant genes in indigenous Chinese populations. The aim of this study is to identify the allelic frequencies of the chemokine and chemokine receptor genes in the Chinese mainland. Genomic DNA samples extracted from whole blood of 2318 subjects were analyzed by using PCR or PCR/restriction fragment length polymorphism (RFLP) assays, and further confirmed by direct DNA sequencing. Higher frequencies of mutant CCR2-64I (19.15%-28.79%) and SDF1-3’A (19.10% -29.86%) alleles were found in subjects of 8 ethnic groups in the Chinese mainland. In contrast, the △32 mutation in CCRS gene occurs at a very low frequency (0.0016, n=1287) in Han population. A relatively high frequency of CCR5-wt/△32 heterozygotes was observed in Uygurian and Mongolian populations. No A32 mutation allele was detected in Tibetan and other 4 ethnic groups in Yunnan Province. There was no CCR5-m303 mutation in subjects of any ethnic group in the Chinese | WANG Fusheng JIN lei LIU Mingxu HONG Weiguo SHI Hong LEI Zhouyun WANG Jiming DU Qingyou HOU Jing ZHANG Bing JIANG Jiandong WANG Yue LI Yueqi XU Anlong HUANG Honglian LIU Fajun | 2001 | Chinese Science Bulletin2001，46，12： | 6 |
| 3 | Characterization of bbtTICAM from amphioxus suggests the emergence of a MyD88-independent pathway in basal chordates显示文摘MyD88 独立的小径,发信号的二关键 TLR 之一发送,被认为是脊椎动物革新。然而,一个新奇 Toll/interleukin-1 受体(TIR ) 适配器,指明的 bbtTICAM,在基础脊索动物文昌鱼被识别,连接这条小径到无脊椎动物。bbtTICAM 的蛋白质建筑学类似于脊椎动物 TICAM1 的(包含 TIR 适配器 molecule-1,也作为 TRIF 知道) 当种系发生的分析基于 TIR 领域显示了那时, bbtTICAM 是脊椎动物 TICAM1 和 TICAM2 的最旧的 ortholog (包含 TIR 适配器 molecule-2,是也知道电车) 。类似于人的 TICAM1, bbtTICAM 激活 NF-κ以由与受体交往蛋白质交往的一种 MyD88 独立的方式的 B (裂开) 经由它的 RHIM 主题。如此的激活要求 bbtTICAM 形成 homodimers 在里面内涵体,和它可以被文昌鱼 SARM 否定地调整(无菌的 α并且犰狳包含主题的蛋白质) 并且 TRAF2。然而, bbtTICAM 没导致类型的生产我干扰素。因此,我们的学习不仅介绍脊椎动物 TICAM1 和 TICAM2 的祖先的特征,而且从基础脊索动物揭示 MyD88 独立的小径的进化起源,它将帮助理解脊椎动物 TLR 网络的开发。 | Manyi Yang Shaochun Yuan Shengfeng Huang Jun Li Liqun Xu Huiqing Huang Xin Tao Jian Peng Anlong Xu | 2011 | Cell Research2011，21，10： | 5 |
| 4 | Periodic atomization characteristics of an impinging jet injector element modulated by Klystron effect显示文摘An experimental study on the Klystron effect of periodic injection modulated by pressure drop fluctuations on subsequent atomization is conducted. Time-resolved atomization backlit images and atomization Mie scatter images are captured by using the high speed camera. It is found that periodicity of forced atomization relies on pressure drop fluctuation amplitude and phase differences between atomization and pressure drop fluctuations relate to fluctuation frequencies. This feature of periodic atomization induced by Klystron effect corresponds to periodicities and high amplitudes of pressure fluctuations in unstable combustion chambers and chaos and low amplitudes of pressure fluctuations in stable combustions chambers. Drastically periodic varying of gross surface area of droplets with time was shown in Mie scatter images. The importance of periodic impinging jet atomization modulated by pressure drop fluctuations for acoustic liquid propellant combustion instabilities is illustrated. | Anlong YANG Bin LI Shangrong YANG Yunfei XU Longfei LI | 2018 | Chinese Journal of Aeronautics2018，31，10： | 4 |
| 5 | Cardiomyocytes induced from hiPSCs by well-defined compounds have therapeutic potential in heart failure by secreting PDGF-BB显示文摘Recent studies have suggested that transplant of hiPS-CMs is a promising approach for treating heart failure.However,the optimally clinical benefits have been hampered by the immature nature of the hiPS-CMs,and the hiPS-CMs-secreted proteins contributing to the repair of cardiomyocytes remain largely unidentified.Here,we established a saponin+compound optimally induced system to generate hiPS-CMs with stable functional attributes in vitro and transplanted in heart failure mice.Our study showed enhanced therapeutic effects of optimally induced hiPS-CMs by attenuating cardiac remodeling and dysfunction,these beneficial effects were concomitant with reduced cardiomyocytes death and increased angiogenesis.Moreover,the optimally induced hiPS-CMs could gathering to the injured heart and secret an abundant PDGF-BB.The reparative effect of the optimally induced hiPS-CMs in the hypoxia-injured HCMs was mimicked by PDGF-BB but inhibited by PDGF-BB neutralizing antibody,which was accompanied by the changed expression of p-PI3K and p-Akt proteins.It is highly possible that the PI3K/Akt pathway is regulated by the PDGF-BB secreted from the compound induced hiPS-CMs to achieve a longer lasting myocardial repair effect compared with the standard induced hiPS-CMs.Taken together,our data strongly implicate that the compound induced hiPS-CMs promote the recovery of injured hearts via paracrine action.In this process,the paracrine factor PDGF-BB derived from the compound induced hiPS-CMs reduces isoproterenol-induced adverse cardiac remodeling,which is associated with improved cardiac function,and these effects are mediated by the PI3K/Akt pathway,suggesting that the optimally induced hiPS-CMs may serve as a new promising cell therapy for clinical applications. | Hongmei Li Fenfang Wu Guangrui Huang Di Wu Ting Wang Xiashuang Wang Kai Wang Yuyin Feng Anlong Xu | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 2 |
| 6 | Development Zones and Evolvement of Urban Spatial Structure: A Case Study on Lanzhou City | ZHANG Zhibin, Professor, College of Geography and Environment Science, Northwest Normal University, Lanzhou, P. R. China. SHI Anlong, Postgraduate Student, College of Geography and Environment Science, Northwest Normal University, Lanzhou, P. R. China SHI Ke | 2009 | China City Planning Review2009，18，4： | 2 |
| 7 | High-throughput RNA sequencing reveals the anti-inflammatory mechanism of baicalin on Propionibacterium acnes-induced acne in rabbits显示文摘Objective:Propionibacterium acnes(P.acnes)plays an important role in the development of acne,an inflammatory skin disease with a high-incidence.In this study,we used high-throughput RNA sequencing(RNA-seq)to reveal the anti-inflammatory mechanism of baicalin on P.acnes-induced acne in rabbits.Methods:The Kligman method was used to induce acne in the ears of New Zealand rabbits.The effect of baicalin on the acne model was evaluated by the number of acne lesions and hematoxylin and eosin(H&E)staining of acne tissues.Enzyme-linked immunoabsorbent assay was used to measure the protein expression levels of tumor necrosis factor a(TNFA),interleukin-1 b(IL1B),IL6,and IL8 in the serum of rabbits.RNA-seq was performed to investigate the mechanism of anti-inflammatory activities of baicalin on acne.Immunohistochemical analysis and Western blot were used to validate the expression levels of related proteins in acne tissues.Results:Baicalin treatment significantly reduced the number of acne lesions and lesions of the ear as well as levels of serum inflammatory cytokines.RNA-seq data showed that baicalin treatment globally suppressed inflammation,especially the TNF signaling pathway and Staphylococcus aureus infection pathway,in the rabbit acne model.Conclusion: Baicalin effectively ameliorates P. acnes-induced acne in rabbits by suppressingthe inflammatory response in rabbits. | Xingzhe Yang Guangrui Huang Leiming You Honghao Sheng Yuxiu Sun Yuyin Feng Qingyi Lu Anlong Xu | 2019 | Journal of Traditional Chinese Medical Sciences2019，6，3： | 2 |
| 8 | Identification and expression of amphioxus AmphiSmad1/5/8 and AmphiSmad4显示文摘Smad family proteins are identified as intracellular signal mediators of the TGF-β superfamily.In this study,we identified two novel members of the Smad family,termed as AmphiSmad1/5/8 and AmphiSmad4,from Chinese amphioxus.Both AmphiSmad1/5/8 and AmphiSmad4 showed a typical domain structure of Smad proteins consisting of conserved MH1 and MH2 domains.Phylogenetic analysis placed AmphiSmad1/5/8 in the Smad1,5 and 8 subgroup of the R-Smad subfamily,and AmphiSmad4 in the Co-Smad subfamily.The spatial and temporal gene expression patterns of AmphiSmad1/5/8 and AmphiSmad4 showed that they may be involved in the embryonic development of notochord,myotome and alimentary canal,and may help to establish the specification of dorsal-ventral axis of amphioxus.Moreover,AmphiSmad1/5/8 and AmphiSmad4 showed extensive distribution in all adult tissues examined,suggesting that these two genes may play important roles in the morphogenesis of a variety of tissues especially notochord and gonad. | YU XueSong LI JianWei LIU Hui LI XiaoDan CHEN ShangWu ZHANG HongWei XU AnLong | 2011 | Science China(Life Sciences)2011，54，3： | 1 |
| 9 | Nutrient physiology, metabolism, and nutrient-nutrient interactions of the major phenolic acids formed during human microbial fermentation of tea, citrus, and soy flavonoid supplements, only 3,4-dihydroxyphenylacetic acid has antiproliferative activity显示文摘 | Kun Gao Anlong Xu Cyrille Krul | 2006 | The Journal of Nutrition2006，136，1： | 1 |
| 10 | The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells显示文摘 | Kun Gao Susanne M. Henning Yantao Niu Arthur A. Youssefian Navindra P. Seeram Anlong Xu David Heber | 2006 | The Journal of Nutritional Biochemistry2006，，： | 1 |
| 11 | Fecal-associated microbiome differences between traditional Chinese medicine qi-deficiency and balanced constitutions显示文摘Objective:To explore the structural and functional characteristics of the fecal-associated microbiome(FAM)in a traditional Chinese medicine(TCM)qi-deficiency constitution(QDC)by comparing with balanced constitution(BC)and screen the related biomarkers.Methods:In this cross-sectional study,the TCM constitutions of subjects were determined based on published the Classification and Determination of constitution in TCM and further confirmed by a TCM clinician.Clinical characteristics were recorded,and fecal samples were collected for 16S rDNA sequencing using the Illumina Miseq platform.The FAM structure was described using alpha-diversity indexes,beta-diversity indexes,and the relative abundances of the dominant taxa.Differences in the FAM distribution and function were analyzed with a Wilcoxon rank-sum test,MetagenomeSeq,and LEfSe analysis,after which a receiver operating characteristic curve based on the specific operational taxonomic units(OTUs)was constructed to calculate the area under the curve.Results:Our study population was composed of 22 BCs and 9 QDCs.There were no significant differences between the two groups in the distribution of clinical characteristics or alpha-diversity indexes,except for the sweets preference and blood glucose level.In principal coordinate analysis and partial least squares discriminant analysis,the bacterial communities in the BC group samples and QDC group samples clustered separately.Notably,there were 214 OTUs significantly distributed between groups in the MetagenomeSeq analysis,200 OTUs identified by the Wilcoxon rank-sum test,and 6 OTUs found by the LEfSe analysis.Predicted function analysis revealed that six metabolic pathways were distinctly distributed between the two groups.The area under the curve for the receiver operating characteristic curve based on the four specific OTUs was 0.88.Conclusion:Unique FAM structural and related functional characteristics are displayed in individuals with a QDC,and four specific OTUs could be used as QDC biomarkers to assist in clinical diagnosis. | Jianhua Zhen Pengfei Zhao Guangrui Huang Yini Li Lu Zhao Yuhang Zhang Anlong Xu | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，2： | 1 |
| 12 | Protection effects of Naoxingqin against H2O2 induced injury in neuron cell of NG108-15显示文摘 | Bei Weijian Peng Wenlie Xu Anlong | | 0，，： | 1 |
| 13 | Advances in futures and options research显示文摘 | Anlong Li | | 10: 17-410，10，： | 1 |
| 14 | The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells显示文摘 | KUN G SUSANNE M HENNINGA T YANTAO N ARTHURA Y NAVINDRA P S ANLONG X T DAVID H | 2006 | Journal of Nutritional Biochemistry2006，17，： | 1 |
| 15 | The major phenolic acids formed during human microbial fermentation of tea,citrus,and soy flavonoid supplements,only 3,4-dihydroxyphenylacetic acid has antiproliferative activity显示文摘 | Kun Gao Anlong Xu Krul C | 2006 | Journal of Nutrition2006，136，1： | 1 |
| 16 | Clinical implications of AEG-1 in liver metastasis of colorectal cancer显示文摘 | Tao Jiang Anlong Zhu Yuekun Zhu Daxun Piao | 2012 | Medical Oncology2012，，4： | 1 |
| 17 | Anaerobic treatment of kenaf stems wood APMP wastewater显示文摘 | He Yanling Zhang Anlong Yang Shuhui | 1995 | Environ Technol1995，16，： | 1 |
| 18 | Berberine Ameliorates Pro-inflammatory Cytokine-Induced Endoplasmic Reticulum Stress in Human Intestinal Epithelial Cells In Vitro显示文摘 | Xianhua Hao Anlong Yao Jianfeng Gong Weiming Zhu Ning Li Jieshou Li | 2012 | Inflammation2012，，3： | 1 |
| 19 | An experimental study on effect of thermal cycling on monotonic and cyclic re- sponse of cast aluminum alloy-SiC particulate composites显示文摘 | Chen Anlong Arai Yoshio Tsuchida Eiichiro | 2005 | Composites2005，36，： | 1 |
| 20 | Neuroprotective Effects of a Standardized Extract of Diospyros kaki Leaves on MCAO Transient Focal Cerebral Ischemic Rats and Cultured Neurons Injured by Glutamate or Hypoxia显示文摘 | Weijian Bei Wenlie Peng Linquan Zang Zhiyong Xie Dehui Hu Anlong Xu | 2007 | Planta Med2007，，07： | 1 |
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