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| 1 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 2 | Structural and molecular features of intestinal strictures in rats with Crohn's-like disease显示文摘AIM: To develop a new rat model we wanted to gain a better understanding of stricture formation in Crohn's disease(CD).METHODS: Chronic colitis was induced locally by the administration of 2,4,6-trinitrobenzenesulfonic acid(TNBS). The relapsing inflammation characteristic to CD was mimicked by repeated TNBS treatments. Animals were randomly divided into control, once, twice and three times TNBS-treated groups. Control animals received an enema of saline. Tissue samples were taken from the strictured colonic segments and also adjacent proximally and distally to its 60, 90 or 120 d after the last TNBS or saline administrations. The frequency and macroscopic extent of the strictures were measured on digital photographs. The structural features of strictured gut wall were studied by light- and electron microscopy. Inflammation related alterations in TGF-beta 2 and 3, matrix metalloproteinases 9(MMP9) and TIMP1 m RNA and protein expression were determined by quantitative real-time PCR and western blot analysis. The quantitative distribution of caspase 9 was determined by post-embedding immunohistochemistry.RESULTS: Intestinal strictures first appeared 60 d after TNBS treatments and the frequency of them increased up to day 120. From day 90 an intact lamina epithelialis, reversible thickening of lamina muscularis mucosae and irreversible thickening of the muscularis externa were demonstrated in the strictured colonic segments. Nevertheless the morphological signs of apoptosis were frequently seen and excess extracellular matrix deposition was recorded between smooth muscle cells(SMCs). Enhanced caspase 9 expression on day 90 in the SMCs and on day 120 also in myenteric neurons indicated the induction of apoptosis. The m RNA expression profile of TGF-betas after repeated TNBS doses was characteristic to CD, TGF-beta 2, but not TGF-beta 3 was up-regulated. Overexpression of MMP9 and down-regulation of TIMP1 were demonstrated. The progressive increase in the amount of MMP9 protein in the strictures was also obvious between days 90 and 120 but TIMP1 protein was practically undetectable at this time.CONCLUSION: These findings indicate that aligned structural and molecular changes in the gut wall rather than neuronal cell death play the primary role in stricture formation. | Petra Talapka Anikó Berkó Lajos István Nagy Lalitha Chandrakumar Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2016 | World Journal of Gastroenterology2016，22，22： | 3 |
| 3 | Hydrogen storage characteristics of Ti 2 Ni alloy synthesized by the electro-deoxidation technique显示文摘 | Mustafa Anik Bedri Baksan Tu?ba ?l?er Orbay Nilüfer Kü?ükdeveci Alanur Binal Aybar Re?at Can ?zden Hakan Ga?an Nur?en Ko? | 2014 | Intermetallics2014，，： | 2 |
| 4 | Simultaneous detection of A and B trichothecenes by gas chromatography with flame ionization or mass selective detection显示文摘 | Zsuzsanna Eke Anikó Kende Kornél Torkos | 2004 | Microchemical Journal2004，，2： | 1 |
| 5 | Pedicle morphology of the thoracic spine in preadolescent idiopathic scoliosis:magnetic resonance supported analysis显示文摘 | Catan H Bulu L Anik Y | 2007 | Eur Spine J2007，16，8： | 1 |
| 6 | Fluorescence sodium-guided surgery in glioblastoma multifore:a prospective evaluation显示文摘 | Koc K Anik L Cabuk B | 2008 | B J Neumsug2008，22，1： | 1 |
| 7 | Metallophysical processes in the welding o{ copper and copper alloy welding methods显示文摘 | ANIK S DORN L | 1988 | Welding and Cutting1988，，9： | 1 |
| 8 | Pedicle morphology of the thoracic spine in preadolescent idiopathic scoliosis:magnetic resonance supported analysis显示文摘 | Catan H Buluc L Anik Y | 2007 | Eur Spine J2007，16，8： | 1 |
| 9 | Analysis of gene expression associated with cold acclimation in blueberry floral buds using expressed sequence tags显示文摘 | Dhanaraj Anik L Slovin Janetp Rowland Lisa J | | 0，，166： | 1 |
| 10 | Isolation of a cD-NA clone and characterization of expression of the highly abundamt,cold acclimation-associated 14 kDa dehydrin of blueberry显示文摘 | Dhanaraj Anik L Slovin Janetp Rowland Lisa J | | 0，，168： | 1 |
| 11 | Simultaneous detection of A and B trichothecenes by gas chromatography with flame ionization or mass selective detection显示文摘 | Zsuzsanna Eke Anikó Kende Kornél Torkos | 2004 | Microchemical Journal2004，，2： | 1 |
| 12 | The involvement of heme oxygenase-1 activity in the therapeutic actions of 5-aminosalicylic acid in rat colitis显示文摘 | Krisztina Horváth Csaba Varga Anikó Berkó Anikó Pósa Ferenc László Brendan J.R. Whittle | 2007 | European Journal of Pharmacology2007，，3： | 1 |
| 13 | Trace level triacetone-triperoxide identification with SPME-GC-MS in model systems显示文摘 | Anik Kende Ferenc Lebics Zsuzsanna Eke Kornél Torkos | 2008 | Microchim Acta2008，163，： | 1 |
| 14 | Pedicle morphology ofthe thoracic spine in preadolescent idiopathic scoliosis:magnetic resonance supported anal-ysis显示文摘 | Catan H Bulu L Anik Y | 2002 | J Bone JointSurg(Am)2002，84，： | 1 |
| 15 | Endemic carbapenem-resistant A cinetobacter species in Brooklyn, New York:citywide prevalence,interinstitutional spread, and relation to antibiotic usage 显示文摘 | M anikal V M L andman D Saurina G | 2000 | Clin Infect Dis2000，31，： | 1 |
| 16 | Improving ecosystem services in farmlands:beginning of a long-term ecological study with restored flower-rich grasslands显示文摘Biodiversity declines in an unprecedented way,mostly due to land use change.Restoration interventions proved to be one of the most effective tools to halt the decline,especially in ecosystems such as agricultural fields.Evidence-based,locally adapted recommendations on grassland restoration,however,are often missing,so we present a novel approach for such interventions that can be implemented anywhere and that are based on scientific rigor.In a recently started long-term field ecological study,we established 0.5 ha wildflower parcels,using a diverse local seed mixture of 32 insect-visited plant species in Central European agricultural landscapes in 2020.Our focus is on the landscape-scale effects of this ecological intensification on ecosystem services such as crop yield,pollination and pest control,and the long-term monitoring of the successional processes.The aim is to showcase an effective restoration protocol that could serve as a model for future farm management,and provide much-needed evidence for policy on landscape ecological restoration of international relevance. | András Báldi Raoul Pellaton Áron Domonkos Bihaly Viktor Szigeti Eszter Lellei-Kovács András Máté Miklós Sárospataki Zoltán Soltész LászlóSomay AnikóKovács-Hostyánszki | 2022 | Ecosystem Health and Sustainability2022，8，1： | 0 |
| 17 | Input database related uncertainty of Biome-BGCMuSo agroenvironmental model outputs显示文摘Gridded model assessments require at least one climatic and one soil database for carrying out the simulations.There are several parallel soil and climate database development projects that provide sufficient,albeit considerably different,observation based input data for crop model based impact studies.The input database related uncertainty of the Biome-BGCMuSo agro-environmental model outputs was investigated using three and four different gridded climatic and soil databases,respectively covering an area of nearly 100.000 km2 with 1104 grid cells.Spatial,temporal,climate and soil database selection related variances were calculated and compared for four model outputs obtained from 30-year-long simulations.The choice of the input database introduced model output variability that was comparable to the variability the year-to-year change of the weather or the spatial heterogeneity of the soil causes.Input database selection could be a decisive factor in carbon sequestration related studies as the soil carbon stock change estimates may either suggest that the simulated ecosystem is a carbon sink or to the contrary a carbon source on the long run.Careful evaluation of the input database quality seems to be an inevitable and highly relevant step towards more realistic plant production and carbon balance simulations. | Nándor Fodor LászlóPásztor Brigitta Szabó Annamária Laborczi Klára Pokovai Dóra Hidy Roland Hollós Erzsébet Kristóf Anna Kis Laura Dobor AnikóKern Thomas Grünwald Zoltán Barcza | 2021 | International Journal of Digital Earth2021，14，11： | 0 |
| 18 | Bone disorders in experimentally induced liver disease in growing rats显示文摘AIM: To investigate the change of bone parameters in a new model of experimentally induced liver cirrhosis and hepatocellular carcinoma (HCC) in growing rats.METHODS: Fischer-344 rats (n = 55) were used. Carbon tetrachloride (CCl4), phenobarbital (PB), and a single diethylnitrosamine (DEN) injection were used. Animals were killed at wk 8 and 16. Bone mineral content, femoral length, cortical index (quotient of cortical thickness and whole diameter) and ultimate bending load (Fmax)of the femora were determined. The results in animals treated with DEN+PB+CCl4 (DPC, n = 21) were compared to those in untreated animals (UNT,n = 14) and in control group treated only with DEN+PB (DP, n = 20).RESULTS: Fatty liver and cirrhosis developed in each DPC-treated rat at wk 8 and HCC was presented at wk 16. No skeletal changes were found in this group at wk 8,but each parameter was lower (P<0.05 for each) at wk 16 in comparison to the control group. Neither fatty liver nor cirrhosis was observed in DP-treated animals at any time point. Femoral length and Fmax values were higher (P<0.05 for both) in DP-treated animals at wk 8 compared to the UNT controls. However, no difference was found at wk 16.CONCLUSION: Experimental liver cirrhosis and HCC are accompanied with inhibited skeletal growth, reduced bone mass, and decreased mechanical resistance in growing rats. Our results are in concordance with the data of other studies using different animal models. A novel finding is the transiently accelerated skeletal growth and bone strength after a 8-wk long phenobarbital treatment following diethylnitrosamine injection. | Viktória Ferencz Csaba Horváth Béla Kári János Gaál Szilvia Mészáros Zsuzsanna Wolf Dalma Heged(?)s Andrea Horváth Anikó Folhoffer Ferenc Szalay | 2005 | World Journal of Gastroenterology2005，11，45： | 0 |
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