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| 1 | Dectin- 1 isoforms contribute to distinct Th 1/Th 17 cell activation in mucosal candidiasis显示文摘β 的识别;由 dectin-1 的 -glucans 被显示了调停房间激活, cytokine 生产和许多抗真菌的回答。这里,我们报导在到 Candida albicans 的 mucosal 免疫的 dectin-1 的功能的活动被主人的基因背景影响。Dectin-1 在 C57BL/6,然而并非 BALB/c 老鼠为胃肠、阴道的 candidiasis 的合适的控制被要求;事实上,后者当 dectin-1 不在时显示出增加的抵抗。到感染的 dectin-1-deficient C57BL/6 老鼠的危险性在 IL-17A 和芳基烃受体依赖者 IL-22 生产并且在适应 Th1 回答与缺点被联系。相反, dectin-1-deficient BALB/c 鼠标的抵抗与增加的 IL-17A 和 IL-22 生产并且向提供免疫学的存储器的 Th1/Treg 有免疫力的回答扭曲被联系。迥异的正规 / 不在经典中的 NF-κ dectin-1 下游地表明小径的 B 在二不同老鼠紧张被激活。因此,在抗真菌的 mucosal 免疫的 dectin-1 的网活动依赖于主人的基因背景,它在 dectin-1 发信号之上影响天生的 cytokine 生产和适应 Th1/Th17 房间激活。 | Agostinho Carvalho Gloria Giovannini AntoneUa De Luca Carmen D'Angelo Andrea Casagrande Rossana G Iannitti Giovanni Ricci Cristina Cunha Luigina Romani | 2012 | Cellular & Molecular Immunology2012，9，3： | 10 |
| 2 | Albuminuria as a marker of arterial stiffness in chronic kidney disease patients显示文摘AIM:To access the association between albuminuria levels and arterial stiffness in non-diabetic patients with hypertension and chronic kidney disease(CKD) stages 1-2,treated with renin angiotensin blockade agents plus other hypertensive drugs when needed.METHODS:One hundred fifteen patients [median age 52 years(68% males)] were consequently enrolled in the study.For each patient,we recorded gender,age,body mass index(BMI),peripheral systolic blood pressure(p SBP),peripheral diastolic blood pressure,peripheral pulse pressure,central systolic blood pressure(c SBP),central diastolic blood pressure(c DBP),central pulse pressure(c PP),hematocrit,hemoglobin,hs CRP,total cholesterol triglycerides,high-density lipoprotein-C,low-density lipoprotein-C,calcium,phosphorus,parathormone,and albumin,as well as 24 h urine albumin excretion.According to 24-h urine albumin collection,patients were then classified as those with moderately increased albuminuria(formerly called macroalbuminuria)(≤ 300 mg/d) and those with severely increased albuminuria(formerly called macroaluminuria(> 300 mg/d).We considered aortic stiffness(AS) indices [carotid femoral pulse wave velocity(PWVc-f) and augmentation index(AIx)] as primary outcomes ofthe study.We explored potential correlations between severely increased albuminuria and AS indices using a multiple linear regression model.RESULTS:Fifty-eight patients were included in the moderately increased albuminuria group and 57 in the severely increased albuminuria.Blood pressure measurements of the study population were 138 ± 14/82 ± 1.3 mm Hg(systolic/diastolic).There were no significant differences in age,sex,and BP measurements between the two groups.Patients with severely increased albuminuria had higher PWV and AIx than patients with moderately increased albuminuria(P < 0.02,P < 0.004,respectively).In addition these patients exhibited higher BMI(P < 0.03),hs CRP(P < 0.001),and fibrinogen levels(P < 0.02) compared to patients with moderately increased albuminuria.In multivariate linear regression analysis,severely increased albuminuria(β = 1.038,P < 0.010) p SBP(β = 0.028,P < 0.034) and Ht(β = 0.171,P = 0.001) remained independent determinants of the increased PWVc-f.Similarly,severely increased albuminuria(β = 4.385,P < 0.012),c SBP(β = 0.242,P < 0.001),c PP(β = 0.147,P < 0.01) and Ht levels(β = 0.591,P < 0.013) remained independent determinants of increased AIx.CONCLUSION:These findings demonstrate an independent association between AS indices and severely increased albuminuria in non-diabetic,hypertensive patients with CKD stages 1-2 treated with renin angiotensin aldosterone system blockers. | Rigas G Kalaitzidis Despina P Karasavvidou Athina Tatsioni Kosmas Pappas Giorgos Katatsis Angelos Liontos Moses S Elisaf | 2015 | World Journal of Nephrology2015，4，3： | 5 |
| 3 | Thrombotic risk factors in patients with liver cirrhosis: Correlation with MELD scoring system and portal vein thrombosis development显示文摘 | Maria Assunta Zocco Enrico Di Stasio Raimondo De Cristofaro Marialuisa Novi Maria Elena Ainora Francesca Ponziani Laura Riccardi Stefano Lancellotti Angelo Santoliquido Roberto Flore Maurizio Pompili Gian Lodovico Rapaccini Paolo Tondi Giovanni Battista G | 2009 | Journal of Hepatology2009，，4： | 5 |
| 4 | Thrombotic risk factors in patients with liver cirrhosis: Correlation with MELD scoring system and portal vein thrombosis development显示文摘 | Maria Assunta Zocco Enrico Di Stasio Raimondo De Cristofaro Marialuisa Novi Maria Elena Ainora Francesca Ponziani Laura Riccardi Stefano Lancellotti Angelo Santoliquido Roberto Flore Maurizio Pompili Gian Lodovico Rapaccini Paolo Tondi Giovanni Battista G | 2009 | Journal of Hepatology2009，，4： | 2 |
| 5 | 在肝的 G6PT-H6PDH-11HSD1 三个一组和它在新陈代谢的症候群的 pathomechanism 的含意显示文摘 The metabolic syndrome, one of the most common clinical conditions in recent times, represents a combination of cardiometabolic risk determinants, including central obesity, glucose intolerance, insulin resistance, dyslipidemia, non-alcoholic fatty liver disease and hypertension. Prevalence of the metabolic syndrome is rapidly increasing worldwide as a consequence of common overnutrition and consequent obesity. Although a unifying picture of the pathomechanism is still missing, the key role of the pre-receptor glucocorticoid activation has emerged recently. Local glucocorticoid activation is catalyzed by a triad composed of glucose-6-phosphate-transporter, hexose-6-phosphate dehydrogenase and 11β-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum. The elements of this system can be found in various cell types, including adipocytes and hepatocytes. While the contribution of glucocorticoid activation in adipose tissue to the pathomechanism of the metabolic syndrome has been well established, the relative importance of the hepatic process is less understood. This review summarizes the available data on the role of the hepatic triad and its role in the metabolic syndrome, by confronting experimental findings with clinical observations. | Ibolya Czegle Miklós Csala József Mandl Angelo Benedetti István Karádi Gábor Bánhegyi | 2012 | World Journal of Hepatology2012，4，4： | 2 |
| 6 | Mitral peak early diastolic filling velocity to deceleration time ratio as a predictor of prognosis in patients with chronic heart failure and preserved or reduced ejection fraction显示文摘ObjectiveDoppler 导出僧帽形的山峰到减速时间比率(E/DT ) 的早心脏舒张的充满速度为在一般人口预言预后作为参数被建议了。这研究有希望地在就医的病人在临床的、常规 echocardiographic 和 mitral-Doppler 变量上调查 E/DT 的增长的预示的值因为患心脏代偿失调的心失败(HF ).MethodsWe 分析了 95 个 HF 病人(吝啬的年龄 64.8 ±12.2 年) 从 2010 年 1 月在我们的机构就医了到 2012 年 3 月。主要端点是心脏的死亡或住院,无论哪个首先发生了。考克斯回归分析被执行识别 outcomes.ResultsDuring 后续的重要预言者(中部 37.7 个月) 13 个病人死了, 44 为一个心脏的事件被就医。在 univariable 分析,纽约心协会(NYHA ) 功能的班, furosemide 剂量,侧面的有三尖的环形的飞机收缩旅行,减速时间和 E/DT 结果是预兆的。在 multivariable 分析, E/DT 是预后的唯一的预言者(危险比率 = 1.02, P = 0.018 ) ,把增长预示的信息给临床并且另外的 echocardio 图形的措施(从 15.4 ~ 25.2 的全球 chi 平方;P = 0.032 ).ConclusionsE/DT 在 HF 病人给独立、增长的预示的信息。 | Flora Pirozzi AntoneUa Paglia Laura Sasso Pasquale Abete Angelo Carlomagno Carlo G Tocchetti Domenico Bonaduce Mario Petretta | 2015 | Journal of Geriatric Cardiology2015，12，4： | 2 |
| 7 | Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle显示文摘 | D'ANGELO J G BORD N C POSNER GH | 2009 | J Antimicrob Chemother2009，63，1： | 1 |
| 8 | Systematic investigation of monolithic bipolar transistors irradiated with neutrons, heavy ions and electrons for space application 显示文摘 | CONSOLANDI C ANGELO P D FALLICA G | 2006 | Nucl Instr and Meth In Phys Res B2006，252，2： | 1 |
| 9 | Assessing Public-privateResearch Collaboration:is it Possible to Compare University Per-formance显示文摘 | Abramo G D'Angelo C A Solazzi M | 2010 | Scientometrics2010，84，1： | 1 |
| 10 | Visinin-like protein-1: diagnostic and prognostic biomarker in Alzheimer disease 显示文摘 | Tarawneh R D' Angelo G Macy E | 2011 | Ann Neurol2011，70，2： | 1 |
| 11 | Identification of lipoxygenase linoleate decomposition products by direct gas chromatography-mass spectrometry显示文摘 | Angelo A J Legendre M G Dupuy H P | 1980 | Lipids1980，15，： | 1 |
| 12 | Proposed refinement to the superpave high temperature specification parameter for performance graded binder 显示文摘 | Bouldin M G Dongre R D'Angelo J | 2001 | Transportation Research Record2001，，1766： | 1 |
| 13 | Vascular endothelial growth factors and angiogenesis显示文摘 | Frelin C Ladoux A D'angelo G | | 0，，： | 1 |
| 14 | Creep and recovery显示文摘 | D Angelo J A R Dongre G Reinke | 2007 | Public roads2007，，70： | 1 |
| 15 | Association studies of genetic polymorphisms and complex disease显示文摘 | Gambaro G Anglani F D'Angelo A | 2000 | Lancet2000，355，： | 1 |
| 16 | Scheduling real-time mixed-criticality jobs 显示文摘 | BARUAH S K BONIFACI V D' ANGELO G | 2012 | IEEE Transactions on Computers2012，61，8： | 1 |
| 17 | Early life stress downreg- ulates endothelin receptor expression and enhances acute stress- mediated blood pressure responses in adult rats 显示文摘 | Loria AS D'Angelo G Pollock DM | 2010 | Am J Physiol Regul Integr Comp Physio12010，299，1： | 1 |
| 18 | Treatment of symptomatic intracranial arachnoid cysts by stereotactic cyst-ventricular shunting显示文摘 | Gorgoglione L Catapano G | 1999 | Stereotact Funct Neurosurg1999，72，1： | 1 |
| 19 | Nanophase in- termetallic FeAI obtained by sintering after mechanical alloying 显示文摘 | ANGELO L D ONOFRIO L D GONZALEZ G | 2009 | Journal oi' Alloys and Compounds2009，483，12： | 1 |
| 20 | Hypoxic reperfusion of the ischemic heart and oxygen radical generation显示文摘 | Angelos MG Kutala VK Torres CA He G Stoner JD Mohammad M | 2006 | Am J Physiol Heart Circ Physiol2006，290，： | 1 |
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