|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients显示文摘AIM: To determine the composition of both fecal and duodenal mucosa-associated microbiota in irritable bowel syndrome (IBS) patients and healthy subjects using molecular-based techniques. METHODS: Fecal and duodenal mucosa brush samples were obtained from 41 IBS patients and 26 healthy subjects. Fecal samples were analyzed for the composition of the total microbiota using fluorescent in situ hybridization (FISH) and both fecal and duodenal brush samples were analyzed for the composition of bif idobacteria using real-time polymerase chain reaction. RESULTS: The FISH analysis of fecal samples revealed a 2-fold decrease in the level of bifidobacteria (4.2 ± 1.3 vs 8.3 ± 1.9, P < 0.01) in IBS patients compared to healthy subjects, whereas no major differences in other bacterial groups were observed. At the species level, Bifidobacterium catenulatum levels were significantly lower (6 ± 0.6 vs 19 ± 2.5, P < 0.001) in the IBS patients in both fecal and duodenal brush samples than in healthy subjects.CONCLUSION: Decreased bifidobacteria levels in both fecal and duodenal brush samples of IBS patients compared to healthy subjects indicate a role for microbiotic composition in IBS pathophysiology. | Angèle PM Kerckhoffs Melvin Samsom Michel E van der Rest Joris de Vogel Jan Knol Kaouther Ben-Amor Louis MA Akkermans | 2009 | World Journal of Gastroenterology2009，15，23： | 33 |
| 2 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 3 | ConservativeapproachinPeutz-JeghersSyndrome:Single-balloon enteroscopyandsmallbowelpolypectomy显示文摘AIM: To assess the usefulness of the balloon assisted enteroscopy in preventing surgical intervention in pa-tients with Peutz-Jeghers syndrome (PJS) having a small bowel large polyps. METHODS: Seven consecutive asymptomatic pts(age 15-38 years) with PJS have been collected; six under-went polypectomy using single balloon enteroscopy(Olympus SIF Q180) with antegrade approach using push and pull technique. SBE system consists of the SIF-Q180 enteroscope, an overtube balloon control unit(OBCU Olympus Balloon Control Unit) and a dispos-able silicone splinting tube with balloon(ST-SB1). All procedures were performed under general anesthesia. Previously all pts received wireless capsule endos-copy(WCE). Prophylactic polypectomy was reservedmainly in pts who had polyps > 15 mm in diameter. The balloon is inflated and deflated by a balloon control unit with a safety pressure setting range from-6.0 kPa to +5.4 kPa. Informed consent has been obtained from pts or parents for each procedure.RESULTS: Six pts underwent polypectomy of small bowel polyps; in 5 pts a large polyp > 15 mm(range 20-50 mm in diameter) was resected; in 1 patient with WCE negative, SBE was performed for previous surgi-cal resection of gastrointestinal stromal tumors. In 2 pts endoscopic clips were placed due to a polypectomy. No surgical complication have been reported. SBE with resection of small bowel large polyps in PJS pts was useful to avoid gastrointestinal bleeding and emergency laparotomy due to intestinal intussuscep-tions. No gastrointestinal tumors were found in sub-sequent enteroscopic surveillance in all seven pts. In order surveillance, all pts received WCE, upper en-doscopy, ileocolonoscopy every 2 years. No pts had extraintestinal malignant lesions. SBE was performed when WCE was positive for significant polyps(> 15 mm).CONCLUSION: The effective of prophylactic polyp-ectomy of small bowel large polyps(> 15 mm) could be the first line treatment for conservative approach in management of PJS patients. | Torroni F Romeo E Rea F De Angelis P Foschia F Faraci S Federici di Abriola G Contini AC Caldaro T Dall’Oglio L | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，7： | 7 |
| 4 | Sonographic hepatorenal ratio: A noninvasive method to diagnose nonalcoholic steatosis显示文摘 | Valéria Ferreira de Almeida e Borges Angélica L. D. Diniz Helma P. Cotrim Haroldo L. O. G. Rocha Nestor Barbosa Andrade | 2012 | J Clin Ultrasound2012，，1： | 2 |
| 5 | A Review of Synergistic Effect of Photocatalysis and Ozonation on Wastewater Treatment 显示文摘 | Agustina T E Ang H M Vareek V K | 2005 | J Photo- ehem Photobiol C2005，6，4： | 1 |
| 6 | Skeletal muscle infarction in diabetes mellitus显示文摘 | Grigoriadis E Fam AG Starok M Ang LC | 2000 | J Rheumatol2000，27，4： | 1 |
| 7 | Results of the mod- ified Fontan procedure are not related to age at operation显示文摘 | Pace Napoleone C Oppido G Angeli E | 2010 | Eur J Cardiothorac Surg2010，37，： | 1 |
| 8 | Progesterone administration by nasal spray显示文摘 | Cicinelli E Lee EJ Ang SB | 1991 | Fertil Steril1991，56，： | 1 |
| 9 | Activity of paclitaxel by three-hour infusion in Asian patients with metastatic undifferentiated nasopharyngeal cancer显示文摘 | AU E TAN E H ANG P T | 1998 | Ann Oncol1998，9，3： | 1 |
| 10 | External quality assurance schemes:a local perspective显示文摘 | Lee SH Ang E | 2002 | Rinsho Byori2002，50，2： | 1 |
| 11 | Evaluating the use of a targeted multiple intervention strategy in reducing patient falls in an acute care hospital:a randomized controlled trial显示文摘 | Ang E Mordiffi SZ Wong HB | 2011 | J Adv Nurs2011，67，9： | 1 |
| 12 | Nutrient removal efficiency and resource economics of vertical flow and horizontal flow constructed wetlands 显示文摘 | LUEDERIZ V ECKERT E I ANGE W M | 2001 | Ecological Engineering2001，18，2： | 1 |
| 13 | Litter quality and decomposition in a COs-enriched Mediterranean forest ecosystem显示文摘 | DE ANGELIS P CHIGWEREWE K S MUGNOZZA G E S | 2000 | Plant and soil2000，224，： | 1 |
| 14 | Public attitudes to e- mergency medical services in Singapore : EMS day 2002 显示文摘 | ONG M E H ANG P H Y CHAN Y H | 2004 | Singa- pore Med2004，45，9： | 1 |
| 15 | Reconstructive options in the treatment of osteoradionecrosis of the eraniomaxillofaeial skeleton 显示文摘 | Ang E Black C Irish J | 2003 | Br J Plast Surg2003，56，2： | 1 |
| 16 | Heterogeneity in the development of apoptosis in irradiated murine tumors of different histologies显示文摘 | MEYN R E STEPHENS L C ANG K K | 1993 | Int J Radiat Biol Phys1993，64，： | 1 |
| 17 | Isolation and expansion of adult cardiac stem cells from human and murine heart显示文摘 | Messina E De Angelis L Frati G | | 0，，09： | 1 |
| 18 | Narcissism, extraversionand adolescents,self - presentation on Facebook 显示文摘 | Ong E Y L Ang R P Ho J C M | 2010 | Personality andIndividual Differences2010，50，2： | 1 |
| 19 | A review of synergistic effect of photocatalysis and ozonation on wastewater treatment 显示文摘 | Agustina T E Ang H M Vareek V K | 2005 | Journal of Photochemistry and Photobiology C: Photochemistry Reviews2005，6，4： | 1 |
| 20 | Perfect decomposition techniques in energy and environmental analysis 显示文摘 | Ang B W Liu F L Chew E P | 2003 | Energy Pol icy2003，31，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员