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| 1 | Alterations in the function of circulating mononuclear cells derived from patients with Crohn’s disease treated with mastic显示文摘AIM: To assess the effects of mastic administration on cytokine production of circulating mononuclear cells of patients with active Crohn's disease (CD). METHODS: The study was conducted in patients with established mildly to moderately active CD, attending the outpatient clinics of the hospital, and in healthy controls. Recruited to a 4 wk treatment with mastic caps (6 caps/d, 0.37 g/cap) were 10 patients and 8 controls, all of who successfully completed the protocol. Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), monocyte chemotactic protein-1 (MCP-1), macrophage migration inhibitory factor (MIF) and intracellular antioxidant glutathione (GSH) were evaluated in peripheral blood mononuclear cells (PBMC) before and after treatment. RESULTS: Treating CD patients with mastic resulted in the reduction of TNF-α secretion (2.1 ± 0.9 ng/mL vs 0.5 ± 0.4 ng/mL, P = 0.028). MIF release was signif icantly increased (1.2 ± 0.4 ng/mL vs 2.5 ± 0.7 ng/mL, P = 0.026) meaning that random migration and chemotaxis of monocytes/macrophages was inhibited. No signifi cant changes were observed in IL-6, MCP-1 and GSH concentrations. CONCLUSION: This study shows that mastic acts as an immunomodulator on PBMC, acting as a TNF-α inhibitor and a MIF stimulator. Although further double-blind, placebo-controlled studies in a large number of patients is required to clarify the role of this natural product, this f inding provides strong evidence that mastic might be an important regulator of immunity in CD. | Andriana C Kaliora Maria G Stathopoulou John K Triantaf illidis George VZ Dedoussis Nikolaos K Andrikopoulos | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 2 | Flecainide: Current status and perspectives in arrhythmia management显示文摘Flecainide acetate is a class IC antiarrhythmic agent and its clinical efficacy has been confirmed by the results of several clinical trials. Nowadays, flecainide is recommended as one of the first line therapies for pharmacological conversion as well as maintenance of sinus rhythm in patients with atrial fibrillation and/or supraventricular tachycardias. Based on the Cardiac Arrhythmia Suppression Trial study results, flecainide is not recommended in patients with structural heart disease due to high proarrhythmic risk. Recent data support the role of flecainide in preventing ventricular tachyarrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia associated both with ryanodine receptor and calsequestrin mutations. We herein review the current clinical data related to flecainide use in clinical practice and some concerns about its role in the management of patients with coronary artery disease. | George K Andrikopoulos Sokratis Pastromas Stylianos Tzeis | 2015 | World Journal of Cardiology2015，7，2： | 8 |
| 3 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 4 | Chios mastic treatment of patients with active Crohn's disease显示文摘AIM: To evaluate the effectiveness of mastic administra-tion on the clinical course and plasma inflammatory me-diators of patients with active Crohn’s disease (CD).METHODS: This pilot study was conducted in patients with established mild to moderately active CD, attend-ing the outpatient clinics of the hospital, and in healthy controls. Ten patients and 8 controls were recruited for a 4-wk treatment with mastic caps (6 caps/d, 0.37 g/cap). All patients successfully completed the protocol. CD Ac-tivity Index (CDAI), Nutritional Risk Index (NRI), C-re-active protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), monocyte chemotactic protein-1 (MCP-1), and total antioxidant potential (TAP) were evaluated in the plasma at baseline and at the end of the treatment period. Results were expressed as mean values ± SE and P < 0.05 was considered to indicate statistical significance.RESULTS: Patients exhibited significant reduction of CDAI (222.9 ± 18.7 vs 136.3 ± 12.3, P = 0.05) as com-pared to pretreament values. Plasma IL-6 was signifi-cantly decreased (21.2 ± 9.3 pg/mL vs 7.2 ± 2.8 pg/ mL, P = 0.027), and so did CRP (40.3 ± 13.1 mg/mL vs 19.7 ± 5.5, P = 0.028). TAP was significantly increased (0.15 ± 0.09 vs 0.57 ± 0.15 mmol/L uric acid, P = 0.036). No patient or control exhibited any kind of side effects. CONCLUSION: The results suggest that mastic signifi-cantly decreased the activity index and the plasma levels of IL-6 and CRP in patients with mildly to moderately ac-tive CD. Further double-blind, placebo-controlled studies in a larger number of patients are required to clarify the role of this natural product in the treatment of patients with CD. | Andriana C Kaliora Maria G Stathopoulou John K Triantafillidis George VZ Dedoussis Nikolaos K Andrikopoulos | 2007 | World Journal of Gastroenterology2007，13，5： | 7 |
| 5 | Evolution of endoscopic extraperitoneal radical prostatectomy (EERPE): technique and outcome显示文摘内视镜的 extraperitoneal 激进分子前列腺切除术(EERPE ) 是为与局部性的前列腺癌症对待病人的一种生长得很好、标准化的技术。不过,过程连续地与解剖知识的扩大正在被精制。没有以力量,克制和 oncological 管理牺牲过程的确定的好处,在当前使用的设备的一条神经圆材途径和改进的发展被期望在 cosmesis 和康复产出更好的结果。在这研究,这种技术和它的进化详细被介绍,与它的临床的功效的分析一起。我们也请教文学把 EERPE 比作 transperitoneal laparoscopic 激进分子前列腺切除术,并且我们也在 EERPE 期间关于机器的帮助的使用讨论新技术前进。 | Jens-Uwe Stolzenburg Odysseas Andrikopoulos Panagiotis Kallidonis Iason Kyriazis Minh Do Evangelos Liatsikos | 2012 | Asian Journal of Andrology2012，14，2： | 5 |
| 6 | Simple electrocardiographic markers for the prediction of paroxysmal idiopathic atrial fibrillation显示文摘 | Polychronis E. Dilaveris Elias J. Gialafos Skevos K. Sideris Artemis M. Theopistou George K. Andrikopoulos Michael Kyriakidis John E. Gialafos Pavlos K. Toutouzas | 1998 | American Heart Journal1998，，5： | 2 |
| 7 | Increased Variance of P wave duration on the electrocardiogram distinguishes Patients with idiopathic paroxysmal atrial fibrillation 显示文摘 | Andrikopoulos GK Dilaver PE Richter DI | 2000 | PACE2000，23，： | 1 |
| 8 | Analysis of olive oil and seed oil triglycerides by capillary gas chromatography as a tool for the detection of the adulteration of olive oil显示文摘 | ANDRIKOPOULOS N K GIANNAKIS I G TZAMTZIS V | 2001 | Journal of Chromatographic Science2001，39，4： | 1 |
| 9 | A synthesis of the production function and the shift-share model: A new regional modeling approach 显示文摘 | Andrikopoulos A A | 1980 | Regional Science and Urban Economics1980，10，4： | 1 |
| 10 | Ip routing issues in satellite constellation networks 显示文摘 | Wood L Clerget A Andrikopoulos I | 2001 | International Journal of Satellite Communications2001，19，1： | 1 |
| 11 | Eleetrieal storm is an in- dependent predictor of adverse long-term outcome in the era of implantable defibrillator therapy显示文摘 | Gatzoulis KA Andrikopoulos LT | 2005 | Europace2005，7，2： | 1 |
| 12 | Irreversible investment, managerial discretion and optimal capital structure显示文摘 | Andrikopoulos A | 2009 | Journal of Banking & Finance2009，33，4： | 1 |
| 13 | Increased variance of P wave duration on the electrocardiogram distinguishes patients with idiopathic paroxysmal atrial fibrillation显示文摘 | Andrikopoulos GK Dilaveris PE Richter DJ | 2000 | Pacing Clin Electrophysiol2000，23，7： | 1 |
| 14 | Raman scattering study of GeTe and Ge2Sb2Te5 phase-change materials显示文摘 | ANDRIKOPOULOS K S YANNOPOULOS S N KOLOBOV A V | 2007 | Journal of Physics and Chemistry of Solids2007，68，56： | 1 |
| 15 | Glutathione depletion restores the susceptibility of cisplatin-resistant chronic myelogenous leukemia cell lines to Natural Killer cell mediated cell death via recrosis rather than apoptosis显示文摘 | Dedoussis GV Andrikopoulos AK | 2001 | Eur J Cell Biol2001，80，9： | 1 |
| 16 | Alternate site pacing in patients at risk for heart failure显示文摘 | Manolis AS Sakellariou D Andrikopoulos GK | 2008 | Angiology2008，59，2： | 1 |
| 17 | Increased variance of P wave duration on the electrocardiogram distinguishes patients with idiopathic paroxysmal atrial fibrillation显示文摘 | Andrikopoulos G K Dilaveris P E Richter D J | 2000 | Pace2000，23，7： | 1 |
| 18 | Increased dietary fat promotes islet amylold formation and beta-cen secretory dysfunction in a transgenic mouse model of islet amyloid 显示文摘 | Hull RL Andrikopoulos S Verehere CB | 2003 | Diabetes2003，52，2： | 1 |
| 19 | Irreversible Investment, Managerial Discretion and Optimal Capital Structure 显示文摘 | Andrikopoulos A | 2009 | Journal of Banking and Finance2009，33，4： | 1 |
| 20 | Differential Effect of Inbred Mouse Strain(C57BL/6J, DBA/2, 129T2) on Insulin Secretory Function in Response to a High Fat Diet 显示文摘 | Andrikopoulos S Massa C M Aston Mourney K | 2005 | J Endocrinol2005，187，1： | 1 |
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