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| 1 | CARMA3: A novel scaffold protein in regulation of NF-κB activation and diseases显示文摘CARD recruited membrane associated protein 3 (CARMA3) is a novel scaffold protein. It belongs to the CARMA protein family, and is known to activate nuclear factor (NF)- κB. However, it is still unknown which receptor functions upstream of CARMA3 to trigger NF-κB activation. Recently, several studies have demonstrated that CARMA3 serves as an indispensable adaptor protein in NF-κB signaling under some G protein-coupled receptors (GP- CRs), such as lysophosphatidic acid (LPA) receptor and angiotensin (Ang) Ⅱ receptor. Mechanistically, CARMA3 recruits its essential downstream molecules Bcl10 and MALT1 to form the CBM (CARMA3-Bcl10-MALT1) signalosome whereby it triggers NF-κB activation. GPCRs and NF-κB play pivotal roles in the regulation of various cellular functions, therefore, aberrant regulation of the GPCR/NF-κB signaling axis leads to the development of many types of diseases, such as cancer and atherogenesis. Recently, the GPCR/CARMA3/NF-κB signaling axis has been confirmed in these specific diseases and it plays crucial roles in the pathogenesis of disease progression. In ovarian cancer cell lines, knockdown of CARMA3 abolishes LPA receptor-induced NF-κB activation, and reduces LPA-induced ovarian cancer invasion. In vascular smooth cells, downregulation of CARMA3 substantially impairs Ang-Ⅱ-receptor-induced NF-κB activation, and in vivo studies have confirmed that Bcl10- deficient mice are protected from developing Ang-Ⅱ-receptor-induced atherosclerosis and aortic aneurysms. In this review, we summarize the biology of CARMA3, describe the role of the GPCR/CARMA3/NF-κB signaling axis in ovarian cancer and atherogenesis, and speculate about the potential roles of this signaling axis in other types of cancer and diseases. With a significant increase in the identification of LPA- and Ang-Ⅱ-like ligands, such as endothelin-1, which also activates NF-κB via CARMA3 and contributes to the development of many diseases, CARMA3 is emerging as a novel therapeutic target for various types of cancer and other diseases. | Jiyuan Sun, Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, TX 77030, United States | 2010 | World Journal of Biological Chemistry2010，1，12： | 2 |
| 2 | Outsmarting cancer:an international brainstorm in Guangzhou显示文摘Cancer is the most deadly disease in the United States.In developing countries such as China, cancer is increasingly prevalent as a cause of death.The “war against cancer” that was initially declared in the United States has become a global war that requires an alliance of world-wide cancer researchers.As part of such an effort, the Second Guangzhou International Symposium on Oncology was held on May 20-22, 2011, in Guangzhou, China. | Chao-Nan Qian 1,2 and Wei Zhang 31 Laboratory of Cancer and Developmental Cell Biology,Van Andel Research Institute,Grand Rapids,MI 49503,USA 2 State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Center,Guangzhou,Guangdong 510060,P.R.China 3 Department of Pathology,University of Texas MD Anderson Cancer Center,Huston,TX 77030,USA. | 2011 | Chinese Journal of Cancer2011，30，8： | 2 |
| 3 | Expression of the sodium iodide symporter and thyroglobulin genes are reduced in papillary thyroid cancer显示文摘 | Ringel MD Anderson J Souza SL | 2001 | Mod Pathol2001，14，4： | 1 |
| 4 | Evaluation of C-reactive protein,an inflammatory marker and infection serology as risk factors for coronary disease and myocardial infarction显示文摘 | Jeffery L Anderson MD Face JF | 1998 | J Am Coil Cardiol1998，32，1： | 1 |
| 5 | The American customer satisfaction index:nature,purpose,and findings显示文摘 | Fornell C Johnson MD Anderson EW Cha J Bryant BE | 1996 | The Journal of Mar_ket_ing1996，60，： | 1 |
| 6 | Close relation of endothelial function in the human coronary and peripheral circualations显示文摘 | Anderson TJ Uehata A Gerhard MD | 1995 | J Am Coll Cardiol1995，26，： | 1 |
| 7 | Global trends in breast cancer incidence and mortality 1973-1997显示文摘 | Althuis MD Doffer JM Anderson WF | 2005 | Int J Epidemi- ol2005，34，2： | 1 |
| 8 | Globaltrends in breast cancer incidence and mortality 1973~1997显示文摘 | DozierJM Anderson WF | 2005 | Int J Epidemiol2005，34，： | 1 |
| 9 | Evaluation of C-reactive protein, an inflammatory marker and infection serology as risk factors for coronary disease and myocardial infarction 显示文摘 | Jeffery L Anderson MD Face J F | 1998 | JAm Coll Cardiol1998，31，1： | 1 |
| 10 | The American customer satisfaction index: Nature, purpose, and find- ings 显示文摘 | Fornell C Johnson MD Anderson EW | 1996 | The Journal of Marketing1996，4，60： | 1 |
| 11 | Close relation of endothelial function in the human coronary and peripheral circulations 显示文摘 | Anderson TJ Uehata A Gerhard MD | 1995 | J Am Coil Cardiol1995，26，5： | 1 |
| 12 | Nicotine replacement therapy patterns of use after a quit attempt among methadone maintained smokers显示文摘 | Stein MD Anderson BJ Niaura R | 2006 | J Gen Intern Med2006，21，7： | 1 |
| 13 | Close relation of endothedial functionin the human coronary and periphend circula-tion显示文摘 | Anderson TJ Uehata A Gerhard MD | 1995 | J Am Coil Cardiol1995，26，： | 1 |
| 14 | Evaluation of Creaction protein, an inflammatory marker and infectious serology as risk factor for coronary heart disease and myocardial infarction 显示文摘 | Jeffery L Anderson MD Face JF | 1998 | J Am Cardiol1998，32，： | 1 |
| 15 | Close relationship of endothelial function in the human coronary and peripheral circulations显示文摘 | Anderson AD Uehata A Gerhard MD | 1995 | J Am Coll Cardiol1995，26，： | 1 |
| 16 | Close relation of endothelial function in the human coronary and peripheral circulations显示文摘 | ANDERSON TJ UEHATA A GERHARD MD | 1995 | J Am Coil Cardiol1995，26，： | 1 |
| 17 | Close relationship of endothelial function in the human coronary and peripheral circulations显示文摘 | Anderson AD Uehata A Gerhard MD | 1995 | J Am Coil Cardiol1995，26，： | 1 |
| 18 | Globaltrends in breast cancer incidence and mortality 1973-1997 显示文摘 | Althuis MD DozierJD Anderson WF | 2005 | Int J Epidemiol2005，34，2： | 1 |
| 19 | Is male breast cancer similar or different than female breast cancer 显示文摘 | Anderson WF Althuis MD Brinton LA | 2004 | Breast Cancer Res Treat2004，83，1： | 1 |
| 20 | The American customer satisfaction index: nature, purpose, and findings 显示文摘 | Fomel| C Johnson MD Anderson EW | 1996 | Journal ofMarketing1996，60，4： | 1 |
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