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| 1 | The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease显示文摘Mammary and extramammary Paget’s Diseases(PD)are a malignant skin cancer characterized by the appearance of Paget cells.Although easily diagnosed,its pathogenesis remains unknown.Here,single-cell RNA-sequencing identified distinct cellular states,novel biomarkers,and signaling pathways—including mTOR,associated with extramammary PD.Interestingly,we identified MSI1 ectopic overexpression in basal epithelial cells of human PD skin,and show that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological,single-cell and molecular levels.Using this mouse model,we identified novel biomarkers of Paget-like cells that translated to human Paget cells.Furthermore,single-cell trajectory,RNA velocity and lineage-tracing analyses revealed a putative keratinocyte-to-Paget-like cell conversion,supporting the in situ transformation theory of disease pathogenesis.Mechanistically,the Msi1-mTOR pathway drives keratinocyte-Paget-like cell conversion,and suppression of mTOR signaling with Rapamycin significantly rescued the Paget-like phenotype in Msi1-overexpressing transgenic mice.Topical Rapamycin treatment improved extramammary PD-associated symptoms in humans,suggesting mTOR inhibition as a novel therapeutic treatment in PD. | Yongli Song Christian F.Guerrero-Juarez Zhongjian Chen Yichen Tang Xianghui Ma Cong Lv Xueyun Bi Min Deng Lina Bu Yuhua Tian Ruiqi Liu Ran Zhao Jiuzhi Xu Xiaole Sheng Sujuan Du Yeqiang Liu Yunlu Zhu Shi-jun Shan Hong-duo Chen Yiqiang Zhao Guangbiao Zhou Jianwei Shuai Fazheng Ren Lixiang Xue Zhaoxia Ying Xing Dai Christopher J.Lengner Bogi Andersen Maksim V.Plikus Qing Nie Zhengquan Yu-Show | 2020 | Cell Research2020，30，10： | 2 |
| 2 | Obesity relationships with community design,physical activity,and time spent in cars显示文摘 | Frank LD Andersen MA Schmid TL | 2004 | Am J Prev Med2004，，27： | 1 |
| 3 | A randomized controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants: the PINT study 显示文摘 | Kirpalani H Whyte RK Andersen C Asztalos EV Heddle N Blajchman MA | 2006 | J Pediatr2006，149，3： | 1 |
| 4 | Obesity relationships with community design, physical activity, and time spent in cars 显示文摘 | Frank LD Andersen MA Schmid TL | 2004 | Am J Prey Med2004，27，： | 1 |
| 5 | Prolonged preseasonal treatment phase with Grazax sublingual immunothera- py increases clinical efficacy显示文摘 | CALDERON MA BIRK AO ANDERSEN JS | 2007 | Allergy2007，62，8： | 1 |
| 6 | Significance of proliferating cell nuclear antigen in predicting recurrence of intracranial meningiomas显示文摘 | Cobb MA Husain M Andersen BJ | | 0，，： | 1 |
| 7 | Com petitiveinhibition of thyroidal uptake of die tary iodide by pe rchloratedoes no t describe perturbations in ratserum to ta and TSH显示文摘 | McLanahan ED Andersen MA Campbe JL | 2009 | Environ Health Perspect2009，117，5： | 1 |
| 8 | The outcome of sternalwire removal on persistent anterior chest wall pain after mediansternotomy显示文摘 | Nφrgaard MA Andersen TC Lavrsen MJ | | 0，，06： | 1 |
| 9 | The microvascular changes in cases of hereditary multi-infarct disease of the brain 显示文摘 | Zhang WW Ma KC Andersen O | 1994 | Acta Neuropathol1994，87，3： | 1 |
| 10 | Low rate of CMV end-organ disease in HIV-infeeted patients despite low CD4 + cell counts and CMV viremia: results of ACTG protocol A5030 显示文摘 | Wohl DA Kendall MA Andersen J | 2009 | HIV Clin Trials2009，10，3： | 1 |
| 11 | Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors显示文摘 | Hentzer M Wu H Andersen JB Riedel K Rasmussen TB Bagge N Kumar N Schembri MA Song Z Kristoffersen P Manefield M Costerton JW Molin S Eberl L Steinberg P Kjelleberg S Hiby N Givskov M | 2003 | EMBO J2003，22，15： | 1 |
| 12 | Low rate of CMV end-organ disease in HIV-infected patients despite low CD4+ cell counts and CMV viremia: resuhs of ACTG protocol A5030 显示文摘 | Wohl DA Kendall MA Andersen J | 2009 | HIV Clin Trials2009，10，3： | 1 |
| 13 | Matrix metalloproteinases (MMP) safeguard osteoblasts from apo-ptosis during transdifferentiation into osteocytes: MT1MMP maintains osteocyte viability 显示文摘 | Karsdal MA Andersen TA Bonewald L | 2004 | DNA Cell Biol2004，23，3： | 1 |
| 14 | Significance of proliferating cell nuclear antigen in predicting recurrence of introcranial meningiomag 显示文摘 | Cobb MA Husain M Andersen B J | 1996 | J Neurosurg1996，84，1： | 1 |
| 15 | The outcome of sternal wire removal on persistent anterior chest wall pain after median sternotomy显示文摘 | Norgaard MA Andersen TC Lavrsen MJ | 2006 | Eur J Cardiothorac Surg2006，29，6： | 1 |
| 16 | Low rate of CMV end-organ disease in HIV-infected patients despite low CD4 + cell counts and CMV viremia: results of ACTG proto- col A5030 显示文摘 | Wohl DA Kendall MA Andersen J | 2009 | HIV Clin Trials2009，10，3： | 1 |
| 17 | Significance of prolifcrating cell nuclear antigen in predicting recurrence of intracranial meningioma显示文摘 | Cobb MA Husain M Andersen BJ | 1996 | J Neurosurg1996，8485，： | 1 |
| 18 | Construction and validation of a web-based epidemiological database for inflammatory bowel diseases in Europe显示文摘 | Johan Burisch Silvija Cukovic-Cavka Ioannis Kaimakliotis Olga Shonová Vibeke Andersen Jens F. Dahlerup Margarita Elkjaer Ebbe Langholz Natalia Pedersen Riina Salupere Kaija-Leena Kolho Pia Manninen Peter Laszlo Lakatos Mary Shuhaibar Selwyn Odes Matteo Ma | 2011 | Journal of Crohn’s and Colitis2011，，4： | 1 |
| 19 | 奥米纽姆摩天大楼显示文摘法兰克福是一座集欧洲古典街区与当代大都市高楼于一体的城市,在城市中心形成了一个充满生机的建筑群落。这种建筑上的结合提供了紧密与动态变化的天际线,与连接法兰克福北部的陶纳斯山脉遥相呼应。奥米纽姆大厦位于城市中建筑高低混合区域的中心,通过周围的环境和建筑来提供一个合理的、具有雕塑感的剪影。BIG建议设计一座塔楼. | Dominic James Black David Verbeek Gunther Weber Helen Chen Joanna Gajda Joseph James Haberl Lukas Kerner Maria Teresa Fernandez Rojo Natalie Isabel Stachnik Nicolas Millot Sabine Kokina Thomas Sebastian Krall Viktoria Millentrup Yan Ma Emily King Enea Michelesio Gabriel■ Ubarevi■iūt■ Giedrius Mamavicius Jesper Boye Andersen Jakob Lange Joanna Jakubowska Katarzyna Joanna Piekarczyk Julieta Muzillo Lorenzo Boddi Lucas Carriere Lucian Tofan Max Aldunate Reitour Raphael Cirani Sabine Kokina Tore Banke Frank Dinger Nils Koenning 陈思瑾(译) | 2019 | 城市环境设计2019，0，2： | 0 |
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