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| 1 | An ingredient for the elixir of youth显示文摘 | Rebecca E Andersen | 2014 | Cell Research2014，24，12： | 5 |
| 2 | Polymorphisms in NF-κB,PXR,LXR,PPARγ and risk of inflammatory bowel disease显示文摘AIM:To investigate the contribution of polymorphisms in nuclear receptors to risk of inflammatory bowel disease(IBD) . METHODS:Genotypes of nuclear factor(NF) -κB(NFKB1) NFκB-94ins/del(rs28362491) ;peroxisome proliferatoractivated receptor(PPAR) -γ(PPARγ) PPARγPro12Ala(rs1801282) and C1431T(rs 3856806) ;pregnane X receptor(PXR) (NR1I2) PXR A-24381C(rs1523127) ,C8055T(2276707) ,and A7635G(rs 6785049) ;and liver X receptor(LXR) (NR1H2) LXR T-rs1405655-C and T-rs2695121-C were assessed in a Danish case-control study of 327 Crohn's disease patients,495 ulcerative colitis(UC) patients,and 779 healthy controls.Odds ratio(OR) and 95%CI were estimated by logistic regression models. RESULTS:The PXR A7635G variant,the PPARγPro12Ala and LXR T-rs2695121-C homozygous variant genotypes were associated with risk of UC(OR:1.31,95% CI:1.03-1.66,P=0.03,OR:2.30,95%CI:1.04-5.08,P=0.04,and OR:1.41,95%CI:1.00-1.98,P=0.05,respectively) compared to the corresponding homozygous wild-type genotypes.Among never smokers,PXR A7635G and the LXR T-rs1405655-C and T-rs2695121-C variant genotypes were associated with risk of IBD(OR:1.41,95%CI:1.05-1.91,P=0.02,OR:1.63,95%CI:1.21-2.20,P=0.001,and OR:2.02,95%CI:1.36-2.99,P=0.0005,respectively) compared to the respective homozygous variant genotypes.PXR A7635G(rs6785049) variant genotype was associated with a higher risk of UC diagnosis before the age of 40 years and with a higher risk of extensive disease(OR:1.34,95%CI:1.03-1.75 and OR:2.49,95%CI:1.24-5.03,respectively) . CONCLUSION:Common PXR and LXR polymorphisms may contribute to risk of IBD,especially among never smokers. | Vibeke Andersen Jane Christensen Anja Ernst Bent A Jacobsen Anne Tjφnneland Henrik B Krarup Ulla Vogel | 2011 | World Journal of Gastroenterology2011，17，2： | 4 |
| 3 | Real-life chromoendoscopy for dysplasia surveillance in ulcerative colitis显示文摘AIM To evaluate the use of chromoendoscopy for surveillance of ulcerative colitis in a real-life community hospital setting.METHODS Patients with extensive ulcerative colitis, having disease duration of more than 8 years and who presented between the years of 1999 to 2013, were offered enrolment in this single cohort prospective study. All participants underwent standard bowel preparation with sodium phosphate and chromoendoscopy. Two expert endoscopists, novice to chromoendoscopy, evaluated each segment of the colon with standarddefinition colonoscopes after spray application of 0.4% indigo carmine. All observed lesions were recorded and evaluated before being removed and/or biopsied. In addition, nontargeted biopsies were taken from each segment of the colon. The dysplasia detection rate and dysplasia detection yield were ascertained. RESULTS A total of 21 neoplastic lesions(2 carcinomas, 4 of high-grade dysplasia and 15 of low-grade dysplasia) and 27 nondysplastic lesions were detected in 16 of the total 67 patients(70% male; median disease duration: 17 years; median age at diagnosis: 25 years; 92% aminosalicylate-treated). The dysplasia detection rate was 10.5%(7/67 patients). The dysplasia detection yield was 20.8%(10/48) for targeted biopsies and 3.5%(11/318) for nontargeted biopsies. The sensitivity and specificity for the macroscopic evaluation of neoplasia using chromoendoscopy were 48% [95% confidence interval(CI): 26%-70%] and 96%(95%CI: 93%-98%), respectively. The positive predictive and negative predictive values were 42%(95%CI: 27%-59%) and 97%(95%CI: 95%-98%), respectively. A total of 19/21 dysplastic lesions were detected in mucosa with histologic inflammation.CONCLUSION Chromoendoscopy seems to be of value for dysplasia surveillance of ulcerative colitis in a community hospital setting. The yield of non-targeted biopsies is negligible. | Pasquale Klepp Anita Tollisen Arne Roseth Milada Cvancarova Smastuen Solveig N Andersen Morten Vatn Bjorn A Moum Stephan Brackmann | 2018 | World Journal of Gastroenterology2018，24，35： | 3 |
| 4 | Phylogenetic analysis of 32 strains of Vaucheria (Xanthophyceae) using the rbcL gene and ITS two flanking space regions显示文摘 | Andersen R A Bailey J C | 2002 | J Phycol2002，38，： | 1 |
| 5 | Determination of the Composition of Calcite-vaterite Mixtures by Infrared Spectrophotometry 显示文摘 | Andersen F A Kralj D | 1991 | Applied Spectroscopy1991，45，10： | 1 |
| 6 | Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG Island显示文摘 | Philibert R Madan A Andersen A | 2007 | Am J Medical Genetics Part B2007，144，1： | 1 |
| 7 | Axin-mediated CKI phosphorylation of beta -catenin at Set 45:a molecular switch for the Wnt pathway显示文摘 | Amit S Hatzubai A Birman Y Andersen J S Ben Shushan E Mann M | 2002 | Genes Dev2002，16，： | 1 |
| 8 | Development of a European Muhimodel Ensemble System for Seasonal - to - interannual Prediction 显示文摘 | Palmer T N Alessandri A Andersen U | 2004 | American Meteorological Society2004，，6： | 1 |
| 9 | Optically stimulated luminescence dating of young estuarine sediments:a comparison with210Pb and 137Cs dating显示文摘 | Madsen A T Murray A S Andersen T J | 2005 | Marine Geology2005，214，： | 1 |
| 10 | Flavonoids from red onion(Allium cepa) 显示文摘 | Fossen T Pedersen A Andersen O M | 1997 | Phytochemistry1997，47，2： | 1 |
| 11 | The structural relation betweenprecipitates in Al-Mg-Si alloys显示文摘 | ANDERSEN S J MARIOARA C D VISSERS R FROSETH A ZANDBERGEN H W | 2007 | Materials Science andEngineering A2007，444，： | 1 |
| 12 | Nueleolar pro- teome dynamics显示文摘 | Andersen J S Lam Y W Leung A K | 2005 | Nature2005，433，： | 1 |
| 13 | Ability to perform activities of daily living is the main factor affecting quality of life in patients with dementia 显示文摘 | Andersen CK Wittrup-Jensen KU Lolk A | 2004 | Health Qual Life Outcomes2004，2，： | 1 |
| 14 | Mapping drug-induced changes in cerebral R2* by Multiple Gradient Recalled Echo functional MRI显示文摘 | Chen Q Andersen A H Zhang Z Ovadia A Gash D M Avison M J | | 0，，05： | 1 |
| 15 | Infrared spectra of amorphous and crystalline calcium carbonate显示文摘 | Andersen F A Brecevic L | 1991 | Acta Chem Scand1991，45，： | 1 |
| 16 | Optimal designs of small CHP plants in a market with fluctuating electricity prices显示文摘 | LUND H ANDERSEN A N | 2005 | Energy Conver- sion and Management2005，46，11： | 1 |
| 17 | Continuum secondary structure captures protein flexibility 显示文摘 | ANDERSEN C A F PALMER A G BRUNAK S | 2002 | Structure2002，10，2： | 1 |
| 18 | Randomised trial of endoscopic endoprosthesis versus operative bypass in malig- nant obstructive jaundice 显示文摘 | Andersen J R Sorensen S M Kruse A | 1989 | Gut1989，30，8： | 1 |
| 19 | Persistent high incidence of tuberculosis in immigrants in a low - incidence country 显示文摘 | Lillebaek T Andersen A B Dirksen A | 2002 | Emerging Infectious Diseases2002，8，7： | 1 |
| 20 | 显示文摘 | Karinen R Andersen JM Ripel A | 2009 | Journal of Analytical Toxicology2009，33，7： | 1 |
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