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| 1 | A gist of gastrointestinal stromal tumors: A review显示文摘Gastrointestinal stromal tumors (GISTs) have been recognized as a biologically distinctive tumor type, different from smooth muscle and neural tumors of the gastrointestinal tract (GIT). They constitute the majority of gastrointestinal mesenchymal tumors of the GIT and are known to be refractory to conventional chemotherapy or radiation. They are defined and diagnosed by the expression of a proto-oncogene protein detected by immunohistochemistry which serves as a crucial diagnostic and therapeutic target. The identification of these mutations has resulted in a better understanding of their oncogenic mechanisms. The remarkable antitumor effects of the molecular inhibitor imatinib have necessitated accurate diagnosis of GIST and their distinction from other gastrointestinal mes-enchymal tumors. Both traditional and minimally invasive surgery are used to remove these tumors with minimal morbidity and excellent perioperative outcomes. The revolutionary use of specific, molecularlytargeted therapies, such as imatinib mesylate, reduces the frequency of disease recurrence when used as an adjuvant following complete resection. Neoadjuvant treatment with these agents appears to stabilize disease in the majority of patients and may reduce the extent of surgical resection required for subsequent complete tumor removal. The important interplay between the molecular genetics of GIST and responses to targeted therapeutics serves as a model for the study of targeted therapies in other solid tumors. This review summarizes our current knowledge and recent advances regarding the histogenesis, pathology, molecular biology, the basis for the novel targeted cancer therapy and current evidence based management of these unique tumors. | Ashwin Rammohan Jeswanth Sathyanesan Kamalakannan Rajendran Anbalagan Pitchaimuthu Senthil-Kumar Perumal UP Srinivasan Ravi Ramasamy Ravichandran Palaniappan Manoharan Govindan | 2013 | World Journal of Gastrointestinal Oncology2013，5，6： | 27 |
| 2 | Implications of the presence of an aberrant right hepatic artery in patients undergoing pancreaticoduodenectomy显示文摘AIM:To analyze the differences in outcomes and the clinical impact following pancreatoduodenectomy(PD)in patients with and without aberrant right hepatic artery(aRHA).METHODS:All patients undergoing PD between January 2008 and December 2012 were divided into two groups,one with aRHA and the other without.These groups were compared to identify differences in the intraoperative variables,the oncological clearance and the postoperative morbidity,mortality and hospital stay.RESULTS:A total of 225 patients underwent PD,of which 43(19.1%)patients were found to have eitheraccessory or replaced right hepatic arteries(aRHA group).The aRHA was preserved in 79%of the patients.There was no significant difference in the intraoperative blood loss but operative time was prolonged,reflecting the complexity of the procedure[420±44(240-540)min vs 480±45(300-600)min,P<0.05)].There were no differences in the incidence of postoperative complications(pancreatic leak,pancreatic fistula,delayed gastric emptying and mortality)and hospital stay.Oncological clearance in the form of positive resection margins[13(7.1%)vs 3(6.9%)]and lymph node yield were also similar in the two groups.CONCLUSION:An aRHA is found in approximately one fifth of patients undergoing PD.Preservation is technically possible in most patients and can increase the operative complexity but does not negatively affect the safety or oncological outcomes of the procedure. | Ashwin Rammohan Ravichandran Palaniappan Anbalagan Pitchaimuthu Kamalakannan Rajendran Senthil Kumar Perumal Kesavan Balaraman Ravi Ramasamy Jeswanth Sathyanesan Manoharan Govindan | 2014 | World Journal of Gastrointestinal Surgery2014，6，1： | 3 |
| 3 | SDN assisted Stackelberg Game model for LTE-WiFi offloading in 5G networks显示文摘The data traffic that is accumulated at the Macro Base Station(MBS)keeps on increasing as almost all the people start using mobile phones.The MBS cannot accommodate all user’s demands,and attempts to offload some users to the nearby small cells so that the user could get the expected service.For the MBS to offload data traffic to an Access Point(AP),it should offer an optimal economic incentive in a way its utility is maximized.Similarly,the APs should choose an optimal traffic to admit load for the price that it gets from MBS.To balance this tradeoff between the economic incentive and the admittance load to achieve optimal offloading,Software Defined Networking(SDN)assisted Stackelberg Game(SaSG)model is proposed.In this model,the MBS selects the users carefully to aggregate the service with AP,so that the user experiencing least service gets aggregated first.The MBS uses the Received Signal Strength Indicator(RSSI)value of the users as the main parameter for aggregating a particular user for a contract period with LTE and WiFi.Each player involved in the game tries to maximize their payoff utilities,and thus,while incorporating those utilities in real-time scenario,we obtain maximum throughput per user which experiences best data service without any lack in Quality of Experience(QoE).Thus,the proposed SaSG model proves better when compared with other game theory models,and hence an optimal data offloading is achieved. | Sudha Anbalagan Dhananjay Kumar Gunasekaran Raja Alkondan Balaji | 2019 | Digital Communications and Networks2019，5，4： | 3 |
| 4 | Landslide hazard and risk assessment mapping of mountainous terrains: A case study from Kumaun Himalaya显示文摘 | Anbalagan R Singh B | 1996 | Engineering Geology1996，43，： | 1 |
| 5 | Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy显示文摘 | Anbalagan S Pires IM Blick C | 2012 | Radiothera- py 0ncol2012，103，3： | 1 |
| 6 | Improvement in dysphagia and quality of life with self-expanding metallic stents in malignant esophageal strictures 显示文摘 | MAROJU NK ANBALAGAN P KATE V | 2006 | Indian J Gastroenterol2006，25，2： | 1 |
| 7 | Effect of polychlorinated biphenyl, Aroclor 1254 on rat epididymis显示文摘 | Anbalagan J Kanagaraj P Srinivasan N | 2003 | Indian J Med Res2003，118，： | 1 |
| 8 | Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy显示文摘 | Anbalagan S Pires IM Blick C | | 0，，03： | 1 |
| 9 | Spectroscopic characterization of natural calcite minerals显示文摘 | Gunasekaran S Anbalagan G | 2007 | Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy2007，68，3： | 1 |
| 10 | Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion显示文摘 | Victor BC Anbalagan A Mohamed MM et a| | 2011 | Breast Cancer Res2011，13，6： | 1 |
| 11 | Thermal decomposition of natural dolomite显示文摘 | Gunasekaran S Anbalagan G | | 0，，04： | 1 |
| 12 | Improvement in dysphagia and quality of life with self-ecpandinmetallic stents inmalignant esophageal strictures显示文摘 | Maroju NK Anbalagan P Kat EV | 2006 | Indian J Gastroenterol2006，25，2： | 1 |
| 13 | Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion显示文摘 | Victor BC Anbalagan A Mohamed MM | 2011 | Breast Cancer Res2011，13，6： | 1 |
| 14 | Toxicity, mechanism and health effects of some heavy metals 显示文摘 | Jaishankar M Tseten T Anbalagan N | 2014 | Interdiscip Toxicol2014，7，2： | 1 |
| 15 | Spectroscopic characterization of natural chrysotile显示文摘 | Anbalagan G Sivakumar G Prabakaran A R Gunasekaran S | 2010 | Vib Spectrosc2010，52，： | 1 |
| 16 | Spectroscopic characterization of natural chrysotile显示文摘 | ANBALAGAN G SIVAKUMAR G PRABAKARAN A R | 2010 | Vibrational Spectroscopy2010，52，： | 1 |
| 17 | Landslide hazard and risk assessment mapping of mountainous terrains- a case study from kumaun himalaya显示文摘 | Anbalagan R & Singh B | 1996 | India Engineering geology1996，43，： | 1 |
| 18 | Adsorption dynamics and equilibrium studies of Zn(II) onto chitosan显示文摘 | K Anbalagan N Muthulakshmi Andal | 2004 | J Chem Sci2004，116，2： | 1 |
| 19 | Landslide hazard evaluation and zonation mapping in mountainous terrain 显示文摘 | Anbalagan R | 1992 | Engineering Geology1992，32，： | 1 |
| 20 | Landslide Hazard and Risk Assessment Mapping of Mountainous Terrains--A Case Study from Kumaun Himalaya显示文摘 | Anbalagan R Singh B | 1996 | Engineering Geology1996，43，： | 1 |
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