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| 1 | A complete compilation of matrix metalloproteinase expression in human malignant gliomas显示文摘Glioblastomas are characterized by an aggressive local growth pattern, a marked degree of invasiveness and poor prognosis. Tumor invasiveness is facilitated by the increased activity of proteolytic enzymes which are involved in destruction of the extracellular matrix of the surrounding healthy brain tissue. Elevated levels of matrix metalloproteinases(MMPs) were found in glioblastoma(GBM) cell-lines, as well as in GBM biopsies as compared with low-grade astrocytoma(LGA) and normal brain samples, indicating a role in malignant progression. A careful review of the available literature revealed that both the expression and role of several of the 23 human MMP proteins is controversely discussed and for some there are no data available at all. We therefore screened a panel of 15 LGA and 15 GBM biopsy samples for those MMPs for which there is either no, very limited or even contradictory dataavailable. Hence, this is the first complete compilation of the expression pattern of all 23 human MMPs in astrocytic tumors. This study will support a better understanding of the specific expression patterns and interaction of proteolytic enzymes in malignant human glioma and may provide additional starting points for targeted patient therapy. | Carsten Hagemann Jelena Anacker Ralf-Ingo Ernestus Giles H Vince | 2012 | World Journal of Clinical Oncology2012，3，5： | 18 |
| 2 | Hypoxia and cytokines regulate carbonic anhydrase 9 expression in hepatocellular carcinoma cells in vitro显示文摘AIM: To study the expression of carbonic anhydrase(CA) 9 in human hepatocellular carcinoma(HCC) cells.METHODS: We studied CA9 protein, CA9 m RNA and hypoxia-inducible factor-1 alpha(HIF-1α) protein levels in Hep3 B cells exposed in different parallel approaches. In one of these approaches, HCC cells were exposed to extreme in vitro hypoxia(24 h 0.1% O2) without or with interleukin(IL)-1, IL-6, tumor necrosis factoralpha(TNF-α) and transforming growth factor-beta(TGF-β) stimulation for the same hypoxic exposure time or exposed to normoxic oxygenation conditions without or with cytokine stimulation.RESULTS: The tumour cell line analysed showed a strong hypoxic CA9 m RNA expression pattern in response to prolonged severe hypoxia with cell-line specific patterns and a marked induction of CA9 protein in response to severe hypoxia. These results were paralleled by the results for HIF-1α protein under identical oxygenation conditions with a similar expression tendency to that displayed during the CA9 protein expression experimental series. Continuous stimulation with the cytokines, IL-1, IL-6, TNF-α and TGF-β, under normoxic conditions significantly increased the carbonic anhydrase 9 expression level at both the protein and m RNA level, almost doubling the CA9 m RNA and CA9 and HIF-1α protein expression levels found under hypoxia. The findings from these experiments indicated that hypoxia is a positive regulator of CA9 expression in HCC, and the four signal transduction pathways, IL-1, IL-6, TNF-α and TGF-β, positively influence CA9 expression under both normoxic and hypoxic conditions.CONCLUSION: These findings may potentially be considered in the design of anti- cancer therapeutic approaches involving hypoxia-induced or cytokine stimulatory effects on expression. In addition, they provideevidence of the stimulatory role of the examined cytokine families resulting in an increase in CA9 expression under different oxygenation conditions in human cancer, especially HCC, and on the role of the CA9 gene as a positive disease regulator in human cancer. | Feray Kockar Hatice Yildrim Rahsan Ilikci Sagkan Carsten Hagemann Yasemin Soysal Jelena Anacker Ahmed Ayad Hamza Dirk Vordermark Michael Flentje Harun M Said | 2012 | World Journal of Clinical Oncology2012，3，6： | 2 |
| 3 | Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor显示文摘 | Anacker C Zunszain PA Cattaneo A | 2011 | Mol Psychiatry2011，16，7： | 1 |
| 4 | Haloperidol and olanzapine mediate metabolic abnormalities through different molecular pathways显示文摘 | MONDELLI V ANACKER C VERNON AC | 2013 | Transl Psychiatry2013，3，： | 1 |
| 5 | Protection of guinea pigs from experimental Rocky Mountain spotted fever with a cloned antigen of Rickettsia rickettsil 显示文摘 | McDonald GA Anacker RL Mann RE | 1988 | J Infect Dis1988，158，1： | 1 |
| 6 | J Phys Chem显示文摘 | Debye P Anacker E W | 1951 | 55:644-6551951，55，： | 1 |
| 7 | Glucocorticoid receptor and FKBP5 expression is altered following exposure to chronic stress :Modulation by antidepressant treatment显示文摘 | Gianluigi Guidotti Francesca Calabrese Calabrese Anacker | 2013 | Neuropsychopharmacology2013，38，4： | 1 |
| 8 | Interleukin- lbeta : a newregulator of the kynurenine pathway affecting human hippocampal neu- rogenesis 显示文摘 | Zunszain PA Anacker C Cattaneo A | 2012 | N europsychopharmacology2012，37，4： | 1 |
| 9 | Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor显示文摘 | Anacker C Zunszain PA Cattaneo A | 2011 | Mol Psychiatry2011，16，： | 1 |
| 10 | Comparative expression pattern of Matrix-Metalloproteinases in human glioblastoma cell-lines and primary cultures显示文摘 | Hagemann C Anacker J Haas S | | 0，，： | 1 |
| 11 | Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis显示文摘 | Anacker C Cattaneo A Musaelyan K | 2013 | Proc Natl Acad Sic U S A2013，110，21： | 1 |
| 12 | On the ontogeny and physiology of regulatory T cells显示文摘 | Anacker O Ricardo PA Odile BD | 2001 | Immunol Rev2001，182，： | 1 |
| 13 | Allele-specific FKBP5 DNAdemethylation mediates gene-childhood trauma interactions显示文摘 | Klengel T Mehta D Anacker C | 2013 | NatNeurosci2013，16，1： | 1 |
| 14 | Role for the kinase SGKI in stress, depression, and glucocorticoid effects on hippocampal neurogenesis显示文摘 | Anacker C Cattaneo A Musaelyan K | 2013 | Proc Nat! Acad Sci USA2013，110，21： | 1 |
| 15 | Role for the kinase SGK1 in stress,depression,and glucocorticoid effects on hippocampal neurogenesis显示文摘 | Anacker C Cattaneo A Musaelyan K | 2013 | Proc Natl Acad Sci USA2013，110，21： | 1 |
| 16 | Glucocortieoids, cytokines and brain abnormalities in depression显示文摘 | Zunszain PA Anacker C Cattaneo A et at | 2011 | Prog Neu ropsychopharmacol Biol Psychiatry2011，35，3： | 1 |
| 17 | Glucocorticoids,cytokines and brain abnormalities in depression显示文摘 | Zunszain PA Anacker C Cattaneo A | 2011 | Prog Neuropsychopharmacol Biol Psychiatry2011，35，3： | 1 |
| 18 | Role for the kinase SGKI in stress, depression, and glucocorticoid effects on hippocampal neuro?genesis显示文摘 | Anacker C Cattaneo A Musaelyan K | 2013 | Proc Nat! Acad Sci U S A2013，110，21： | 1 |
| 19 | Glucocorticoids, cytokines and brain abnormalities in depression 显示文摘 | Zunszain P A Anacker C Cattaneo A | 2011 | Prog Neuro- psychopharmacol Biol Psychiatry2011，35，3： | 1 |
| 20 | Glucocorticoid- related molecular signaling pathways regulating hippocampal neurogenesis显示文摘 | Anacker C Cattaneo A Luoni A | 2013 | Neuropsychopharmacology2013，38，5： | 1 |
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