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| 1 | Comparative effectiveness of traditional chemoembolization with or without sorafenib for hepatocellular carcinoma显示文摘AIM: To compare the overall survival (OS) and progression-free survival (PFS) with associated adverse events (AE) in patients with unresectable hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE) + sorafenib vs TACE alone. METHODS: In this retrospective cohort study we collected data on all consecutive patients with a diagnosis of unresectable HCC between 2007 and 2011 who had been treated with TACE + sorafenib or TACE alone. We hypothesized that the combination therapy is superior to TACE alone in improving the survival in these patients. Data extracted included patient's demographics, etiology of liver disease, histology of HCC, stage of liver disease with respect to model of end stage liverdisease score and Child-Turcotte-Pugh (CTP) classification and Barcelona Clinic Liver Cancer (BCLC) staging for HCC. Computed tomography scan findings, alpha fetoprotein levels, number of treatments and related AE were also recorded and analyzed. RESULTS: Of the 43 patients who met inclusion criteria, 13 were treated with TACE + sorafenib and 30 with TACE alone. There was no significant difference in median survival: 20.6 mo (95%CI: 13.4-38.4) for the TACE + sorafenib and 18.3 mo (95%CI: 11.8-32.9) for the TACE alone (P = 0.72). There were also no statistically significant differences between groups in OS (HR = 0.82, 95%CI: 0.38-1.77; P = 0.61), PFS (HR = 0.93, 95%CI: 0.45-1.89; P = 0.83), and treatment-related toxicities (P = 0.554). CTP classification and BCLC staging for HCC were statistically significant (P = 0.001, P = 0.04 respectively) in predicting the survival in patients with HCC. The common AE observed were abdominal pain, nausea, vomiting and mild elevation of liver enzymes. CONCLUSION: Combination therapy with TACE + sorafenib is safe and equally effective as TACE alone in patients with unresectable HCC. CTP classification and BCLC staging were the significant predictors of survival. Future trials with large number of patients are needed to further validate this observation. | Adnan Muhammad Manish Dhamija Gitanjali Vidyarthi Donald Amodeo William Boyd Branko Miladinovic Ambuj Kumar | 2013 | World Journal of Hepatology2013，5，7： | 16 |
| 2 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Bilateral breast cancer显示文摘 | Amodeo C Caglia P Gandolfo L | 2003 | Tumori2003，89，4： | 1 |
| 5 | Concomitant gonadotropin-releasing hormone agonist and menotropin treatment for the synchronized induction of multiple follicles显示文摘 | Palermo R Amodeo G Navot D | 1988 | Fertil Steril1988，49，2： | 1 |
| 6 | F- unct ional characterization and localization of AQP3 in the human colon 显示文摘 | SILBERSTEIN C KIERBEL A AMODEO G | 1999 | Braz J Med Biol Res1999，32，： | 1 |
| 7 | Simulation of Cooling Airflow under Different Driving Conditions 显示文摘 | Ales Alajbegovic Bing Xu Alex Konstantinov Joe Amodeo | 2007 | SAE International2007，01，： | 1 |
| 8 | Comparative tissue reactivity to topical hemostatic agents in the periureteral area显示文摘 | Wahlstrom E Yadegar J Amodeo P | 1983 | Arch Surg1983，118，12： | 1 |
| 9 | Bilateral breast cancer显示文摘 | Amodeo C Caglia P Gandolfo L | 2003 | Tumori2003，89，4： | 1 |
| 10 | Extracardiac Fontan operation for complex cardiac anomalies: seven years' experience 显示文摘 | Amodeo A Galletti L Marianeschi S | 1997 | J Thorac C ardiovasc Surg1997，114，： | 1 |
| 11 | Total cavopulm-onary direct anastomosis : a logical approach in selectedpatients 显示文摘 | CAROTTI A IORIO F S AMODEO A | 1993 | Ann Thorac Surg1993，56，4： | 1 |
| 12 | Perineural dexmed- etomidine added to ropivacaine causes a dose-dependent increase in the duration of thermal antinociception in sciatic nerve block in rat 显示文摘 | Brummett CM Padda AK Amodeo FS | 2009 | Anesthesiology2009，111，5： | 1 |
| 13 | An anatomical study of the nasal,superficial musculoaponeurotic system;surgical applications in rhinoplasty显示文摘 | ANDRETTO AMODEO C HAMMOU J C | 2008 | Arch Fneial Plast Surg2008，10，2： | 1 |
| 14 | Racial and ethnic differences in drug treatment entry of injection drug users in Massachusetts显示文摘 | Lundgren LM Amodeo M Ferguson F | 2001 | J Subst Abuse Treat2001，21，3： | 1 |
| 15 | Erythrocyte deformability and nitric oxide metabolites in athletes before and after a cardiopul- monary test显示文摘 | Caimi G Canino B Amodeo G | 2009 | Clin J Sport Med2009，19，4： | 1 |
| 16 | The role of aquaporins and membrane damage in chilling and hydro gen peroxide induced changes in the hydraulic conductance of maize roots 显示文摘 | Aroca R Amodeo G Fernandez-Illescas S | 2005 | Plant Physiol2005，137，1： | 1 |
| 17 | Perineural dexmedelomidine added to ropivacaine causes a dose-dependent increase in the duration of thermal anti- nociception in sciatic nerve block in rat显示文摘 | Brununett CM Padda AK Amodeo FS | 2009 | Anest- hesiology2009，111，5： | 1 |
| 18 | Perineural dexmedetomidine added to ropivacaine causes a dose-dependent increase in the duration of thermal antinociception in sciatic nerve block in rat显示文摘 | Brummett CM Padda AK Amodeo FS | 2009 | Anesthesiology2009，，5： | 1 |
| 19 | Perineural dexmedetomidine provides an increased duration of anal- gesia to a thermal stimulus when compared with a sys temie control in a rat sciatic nerve block显示文摘 | Brummett CM Amodeo FS Janda AM | 2010 | Reg Anesth Pain Meal2010，35，5： | 1 |
| 20 | The role of aqua- porins and membrane damage in chilling and hydrogen per- oxide induced changes in the hvdraulic conductance of maize roots 显示文摘 | Aroca R Amodeo G Fernandez I S | 2005 | Plant Physio12005，137，： | 1 |
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