|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comparative effectiveness of traditional chemoembolization with or without sorafenib for hepatocellular carcinoma显示文摘AIM: To compare the overall survival (OS) and progression-free survival (PFS) with associated adverse events (AE) in patients with unresectable hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE) + sorafenib vs TACE alone. METHODS: In this retrospective cohort study we collected data on all consecutive patients with a diagnosis of unresectable HCC between 2007 and 2011 who had been treated with TACE + sorafenib or TACE alone. We hypothesized that the combination therapy is superior to TACE alone in improving the survival in these patients. Data extracted included patient's demographics, etiology of liver disease, histology of HCC, stage of liver disease with respect to model of end stage liverdisease score and Child-Turcotte-Pugh (CTP) classification and Barcelona Clinic Liver Cancer (BCLC) staging for HCC. Computed tomography scan findings, alpha fetoprotein levels, number of treatments and related AE were also recorded and analyzed. RESULTS: Of the 43 patients who met inclusion criteria, 13 were treated with TACE + sorafenib and 30 with TACE alone. There was no significant difference in median survival: 20.6 mo (95%CI: 13.4-38.4) for the TACE + sorafenib and 18.3 mo (95%CI: 11.8-32.9) for the TACE alone (P = 0.72). There were also no statistically significant differences between groups in OS (HR = 0.82, 95%CI: 0.38-1.77; P = 0.61), PFS (HR = 0.93, 95%CI: 0.45-1.89; P = 0.83), and treatment-related toxicities (P = 0.554). CTP classification and BCLC staging for HCC were statistically significant (P = 0.001, P = 0.04 respectively) in predicting the survival in patients with HCC. The common AE observed were abdominal pain, nausea, vomiting and mild elevation of liver enzymes. CONCLUSION: Combination therapy with TACE + sorafenib is safe and equally effective as TACE alone in patients with unresectable HCC. CTP classification and BCLC staging were the significant predictors of survival. Future trials with large number of patients are needed to further validate this observation. | Adnan Muhammad Manish Dhamija Gitanjali Vidyarthi Donald Amodeo William Boyd Branko Miladinovic Ambuj Kumar | 2013 | World Journal of Hepatology2013，5，7： | 16 |
| 2 | Safety of gastrointestinal endoscopy with conscious sedation in obstructive sleep apnea显示文摘AIM To perform a systematic review and meta-analysis to assess the safety of conscious sedation in patients with obstructive sleep apnea(OSA).METHODS A comprehensive electronic search of MEDLINE and EMBASE was performed from inception until March 1, 2015. In an effort to include unpublished data, abstracts from prior gastroenterological society meetings as well as other reference sources were interrogated. After study selection, two authors utilizing a standardized data extraction form collected the data independently. Any disagreements between authors were resolved by consensus among four authors. The methodological quality was assessed using the Newcastle Ottawa tool for observational studies. The primary variables of interest included incidence of hypoxia, hypotension, tachycardia, and bradycardia. Continuous data were summarized as odds ratio(OR) and 95%CI and pooled using generic inverse variance under the random-effects model. Heterogeneity between pooled studies was assessed using the I2 statistic.RESULTS Initial search of MEDLINE and EMBASE identified 357 citations. A search of meeting abstracts did not yield any relevant citations. After systematic review and exclusion consensus meetings, seven studies met the a priori determined inclusion criteria. The overall methodological quality of included studies ranged from moderate to low. No significant differences between OSA patients and controls were identified among any of the study variables: Incidence of hypoxia(7 studies, 3005 patients; OR = 1.11; 95%CI: 0.73-1.11; P = 0.47; I2 = 0%), incidence of hypotension(4 studies, 2125 patients; OR = 1.10; 95%CI: 0.75-1.60; P = 0.63; I2 = 0%), incidence of tachycardia(3 studies, 2030 patients; OR = 0.94; 95%CI: 0.53-1.65; P = 0.28; I2 = 21%), and incidence of bradycardia(3 studies, 2030 patients; OR = 0.88; 95%CI: 0.63-1.22; P = 0.59; I2 = 0%).CONCLUSION OSA is not a significant risk factor for cardiopulmonary complications in patients undergoing endoscopic procedures with conscious sedation. | Christian M Andrade Brijesh Patel Meghana Vellanki Ambuj Kumar Gitanjali Vidyarthi | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，11： | 4 |
| 3 | 采用延性损伤模型和数值方法预测Ni-Cr基合金在温成形条件下的断裂极限显示文摘为了确定IN625合金的安全成形和断裂极限,在300和673 K下分别进行拉伸成形和深拉延成形实验。将实验获得的基于应力的断裂成形极限图(FFLD)转变为基于应力的σ-FFLD和有效塑性应变(EPS)跟三轴度(η)的关系曲线,以消除断裂极限对应变的过度依赖。为了预测断裂极限,校准7种不同的损伤模型。结果显示,Oh模型对断裂轨迹的预测能力最好,绝对误差最小。虽然实验得到的断裂极限仅用于数值分析,但没有一个损伤模型预测整个应力三轴度范围(0.33<η<0.66)的断裂应变。在不同的温度和润滑条件下深拉延成形圆柱杯,深拉延工艺窗口有助于确定起皱、安全和断裂区域。在润滑条件下,673 K时达到最大的拉延比2。利用Hill 1948各向异性屈服函数对拉伸成形和深拉延成形过程的数值预测结果均在可接受的误差范围内。 | Ayush MORCHHALE Anand BADRISH Nitin KOTKUNDE Swadesh Kumar SINGH Navneet KHANNA Ambuj SAXENA Chetan NIKHARE | 2021 | Transactions of Nonferrous Metals Society of China2021，31，8： | 3 |
| 4 | No Evidence for Efficacy of Radiofrequency Ablation for Treatment of Gastroesophageal Reflux Disease: A Systematic Review and Meta-analysis显示文摘 | Seth Lipka Ambuj Kumar Joel E. Richter | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 1 |
| 5 | Extracorporeal photopheresis in steroid-refractory acute or chronic graft-versus-host disease: results of a systematic review of prospective studies显示文摘 | Iman Abu-Dalle Tea Reljic Taiga Nishihori Ahmad Antar Ali Bazarbachi Benjamin Djulbegovic Ambuj Kumar Mohamed A. Kharfan-Dabaja | 2014 | Biology of Blood and Marrow Transplantation2014，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员