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| 1 | PacBio Sequencing and Its Applications显示文摘Single-molecule, real-time sequencing developed by Pacific Bio Sciences offers longer read lengths than the second-generation sequencing(SGS) technologies, making it well-suited for unsolved problems in genome, transcriptome, and epigenetics research. The highly-contiguous de novo assemblies using Pac Bio sequencing can close gaps in current reference assemblies and characterize structural variation(SV) in personal genomes. With longer reads, we can sequence through extended repetitive regions and detect mutations, many of which are associated with diseases. Moreover, Pac Bio transcriptome sequencing is advantageous for the identification of gene isoforms and facilitates reliable discoveries of novel genes and novel isoforms of annotated genes,due to its ability to sequence full-length transcripts or fragments with significant lengths. Additionally, Pac Bio's sequencing technique provides information that is useful for the direct detection of base modifications, such as methylation. In addition to using Pac Bio sequencing alone, many hybrid sequencing strategies have been developed to make use of more accurate short reads in conjunction with Pac Bio long reads. In general, hybrid sequencing strategies are more affordable and scalable especially for small-size laboratories than using Pac Bio Sequencing alone. The advent of Pac Bio sequencing has made available much information that could not be obtained via SGS alone. | Anthony Rhoads Kin Fai Au | 2015 | Genomics, Proteomics & Bioinformatics2015，13，5： | 107 |
| 2 | Multidisciplinary approach for post-liver transplant recurrence of hepatocellular carcinoma: A proposed management algorithm显示文摘A large number of liver transplants have been performed for hepatocellular carcinoma(HCC), and recurrence is increasingly encountered. The recurrence of HCC after liver transplantation is notoriously difficult to manage. We hereby propose multi-disciplinary management with a systematic approach. The patient is jointly managed by the transplant surgeon, physician, oncologist and radiologist. Immunosuppressants should be tapered to the lowest effective dose to protect against rejection. The combination of a mammalian target of rapamycin inhibitor with a reduced calcineurin inhibitor could be considered with close monitoring of graft function and toxicity. Comprehensive staging can be performed by dual-tracer positron emission tomography-computed tomography or the combination of contrast computed tomography and a bone scan. In patients with disseminated recurrence, sorafenib confers survival benefits but is associated with significant drug toxicity. Oligo-recurrence encompasses recurrent disease that is limited in number and location so that loco-regional treatments convey disease control and survival benefits. Intra-hepatic recurrence can be managed with graft resection, but significant operative morbidity is expected. Radiofrequency ablation and stereotactic body radiation therapy(SBRT) are effective alternative strategies. In patients with more advanced hepatic disease, regional treatment with trans-arterial chemoembolization or intra-arterial Yttrium-90 can be considered. For patients with extra-hepatic oligorecurrence, loco-regional treatment can be considered if practical. Patients with more than one site of recurrence are not always contraindicated for curative treatments. Surgical resection is effective for patients with pulmonary oligo-recurrence, but adequate lung function is a prerequisite. SBRT is a non-invasive and effective modality that conveys local control to pulmonary and skeletal oligo-recurrences. | Kin Pan Au Kenneth Siu Ho Chok | 2018 | World Journal of Gastroenterology2018，24，45： | 18 |
| 3 | MSM交友应用程序的发展及对MSM危险性行为的影响显示文摘随着交友应用程序(App)在手机客户端的广泛使用,男男性行为人群(MSM)的交友方式发生了较大转变。App使交友变得更加方便和快捷的同时,也使得MSM中无保护性行为日益增多,该人群艾滋病病毒(HIV)/性传播疾病(STD)的流行趋势变得更加严峻。国际上已有越来越多利用App在MSM中进行的干预调查研究,而中国尚处在起步阶段。App的日益普及和功能的不断完善,为在MSM中开展艾滋病的防控工作提供了新的思路。 | 张海波 William W Au 赵锦 | 2015 | 中国艾滋病性病2015，21，10： | 17 |
| 4 | Ecological and Economic Benefits of Vegetation Management Measures in Citrus Orchards on Red Soils显示文摘A three-year experiment was conducted to investigate and compare the economic and ecological benefits of six types of vegetation management measures in citrus orchards of the hilly red soil region of the eastern part of China.Six vegetation treatments,including tillage without herbicide(clean tillage)and no tillage without herbicide(sod culture) and with herbicide paraquat(paraquat),glyphosate(glyphosate),glyphosate-glyphosate-paraquat(G-G-P),and paraquat- paraquat-glyphosate(P-P-G),were applied in the citrus orchards on a clayey red soil with slopes of 8°and 13°and a sandy soil with slope of 25°.The results showed that the sod culture,paraquat,glyphosate,G-G-P,and P-P-G treatments reduced surface runoff by 38.8%,42.5%,18.7%,28.7%,and 37.5%,then the soil-water losses by 55.5%,51.7%,39.9%,46.8%, and 50.0%,and the N,P,and K nutrient losses by 60.3%,50.2%,37.0%,41.8%,and 45.4%,respectively,as compared with the clean tillage treatment.The weed regeneration ratios with the treatments of clean tillage without herbicide,paraquat, glyphosate,G-G-P,and P-P-G were reduced by 55.1%,67.2%,30.3%,36.8%,and 51.2%,respectively,as compared with the sod culture.The sod culture,paraquat,glyphosate,G-G-P,and P-P-G treatments could increase the soil fertility (annual accumulation of N,P,K,and OM)by 7.1%,6.9%,5.3%,6.2%,and 6.6%,respectively,whereas the clean tillage treatment without herbicide reduced soil fertility by 4.4% after the three-year experiment.The citrus fruit yields in the treatments of paraquat,glyphosate,G-G-P,and P-P-G increased by 7%-10%;the soluble solid,total sugar,total acidity,sugar-acid ratio,and single fruit weight of citrus fruits of all treatments except sod culture significantly(P>0.05) exceeded that of the clean tillage treatment.In general,the paraquat treatment showed the best economic and ecological benefits among the six treatments;therefore,it could be regarded as the best available vegetation management measure in citrus orchards of hilly red soil region to retain water and soil,enhance soil fertility,and improve the yield and quality of citrus. | SHUI Jian-Guo WANG Qiu-Zhen LIAO Gen-Qing J. AU J. L. ALLARD | 2008 | Pedosphere2008，18，2： | 16 |
| 5 | Epidemiology of Hepatitis B and Associated Liver Diseases in China显示文摘Hepatitis B virus (HBV) infection has long been a critical public health challenge in China. National surveys revealed a prevalence of approximate 10% for chronic HBV infection in general population. HBV has been the leading cause of chronic hepatitis, cirrhosis, and liver cancers in Chinese population and a common pathogen of acute viral hepatitis. Meanwhile, the epidemic provided important opportunities to research the natural history, public health impact, and therapeutic and preventive interventions for HBV in China. In this review, we summarized the selected key epidemiological studies since 1970s regarding HBV infection and its associated liver diseases in China, and provided considerations for future research, prevention and treatment of HBV. | Yao Zhang Hua Zhang Au Elizabeth Xiao-qing Liu | 2012 | Chinese Medical Sciences Journal2012，27，4： | 16 |
| 6 | Overview of HIV drug resistance and its implications for China显示文摘 | Maria Au Jessica Haberer | 2006 | Chinese Medical Journal2006，，23： | 15 |
| 7 | A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation显示文摘 | Hui CK Lie A Au WY Leung YH Ma SY Cheung WW Zhang HY Chim CS Kwong YL Liang R Lau GK | 2006 | 中国生物学文摘2006，20，5： | 10 |
| 8 | 上海市闸北区学龄前儿童注意缺陷多动障碍患病率及症状分布特征的研究显示文摘目的了解上海市闸北区学龄前儿童注意缺陷多动障碍(ADHD)的症状阳性率和影响因素。方法使用一般情况调查表和注意缺陷多动症状调查表,采取整群-分层抽样的方法对上海市闸北区3~6岁学龄前儿童进行调查。针对注意缺陷多动症状调查表中症状阳性率的总体情况、年龄分布、及其与性别、户籍、家庭情况的关系,进行了比较和分析。结果学龄前儿童ADHD患病率为3.9%,男、女患病率分别为2.5%和1.3%,男、女比例为2:1。大部分症状阳性率大致随年龄增长而递减;阳性率最高年龄段分布于4~5岁;男性阳性率显著高于女性;外地户籍的儿童阳性率高于上海市户籍的儿童;按父母文化程度比较,症状阳性率有显著差异。结论学龄前儿童的注意缺陷症状的阳性率普遍高于多动症状,父母文化程度的高低与儿童ADHD症状严重程度有关。 | 阿依奴尔 吾买尔 杜亚松 金文岚 钟向阳 David Coghill Shunying Au | 2012 | 中国医疗设备2012，27，4： | 10 |
| 9 | 乳腺癌发病相关因素研究现状显示文摘近年来,乳腺癌的发病率、死亡率在世界范围内明显升高。本文就乳腺癌发病相关危险因素———遗传、生理、外源性雌激素、既往病史、生活习惯和环境等作一综述。 | 付晓静 林昆 William W Au | 2011 | 汕头大学医学院学报2011，24，3： | 9 |
| 10 | 中国一线城市旅游竞争力实证及空间分异显示文摘一线城市是现代物质文明和精神文明最前卫、最经典、最集中的地域,对一个国家或地区来说,一线城市旅游在国际上是否具有竞争力优势,决定着这个国家旅游业的整体形象和格局。我国一线城市旅游发展水平很不平衡,需要加以探究。研究发现:第一,城市旅游竞争力是由各个既独立又联系驱动发展因素聚合而成,其中对旅游竞争力具有决定性作用的指标是基础设施竞争力、经济实力竞争力、旅游环境竞争力;第二,中国一线各城市旅游环境竞争空间差异显著。旅游空间结构呈现以深圳、广州、上海、北京为中心的辐射圈,综合竞争力评价排名与我们的认识存在明显的差别;第三,城市旅游竞争力与城市旅游吸引空间分布高度契合,存在明显的相关关系。通过对比研究,以其优长和短板,提出了建言建策。 | 马才巍 Norman Au | 2016 | 东南学术2016，，5： | 8 |
| 11 | Arsenic trioxide: safety issues and their management显示文摘三氧化二砷(As2O3 ) 被使用了为几千年的当做药。它在白血球过多症的治疗学的使用一个世纪以前被描述。为了 As2O3 的最近的重新燃起由于它在尖锐 promyelocytic 白血球过多症(APL ) 的高功效 .As2O3 也在另外的血和稳固的癌症临床上被测试了。大多数研究使用了静脉内的 As2O3,尽管口头的 As2O3 是同等地有效的。As2O3 的副作用通常是次要的,包括皮肤反应,胃肠不安,并且肝炎。这些对症状疗法或暂时的药停止作出回应,并且不在 APL 与 As2O3.During 正式就职治疗损害随后的治疗,白细胞增多可以偶尔发生,它能与液体累积和肺的渗入被联系。条件在有 all-trans retinoic 酸的治疗期间类似于 APL 区别症候群,并且回答 QT 延伸到治疗导致的 cytoreductive 治疗和 corticosteroids.Intravenous As2O3。面对内在的心肺的疾病或电解质骚乱,特别地血钾过少和 hypomagnesaemia,严肃的心律不齐可以发展,与岩山果汁饮料 du, pointes 在 1% 案例中报导了。这可以与一个剂量依赖者有关是损害慢肠吸收的心脏的 repolarization.Because 的钾离子隧道的调停砷的抑制, oral-As2O3 给更低的血浆砷集中,它与更小的 QT 被联系延伸和因此更有利的心脏的安全 profile.As2O3 不看起来进入中枢神经系统。然而,如果血大脑障碍被突破,元素的砷可以进入脑髓的 fluid.As2O3 主要在肾被排泄,并且当肾的功能被损害时,剂量调整被要求。 | Wing-Yan AU Yok-Lam KWONG | 2008 | Acta Pharmacologica Sinica2008，29，3： | 7 |
| 12 | 100%禁烟法令在山东省实施的适用性评估显示文摘评估100%的禁烟法令能否在山东省实施。方法:用文献回顾和关键人物访谈相结合的方法,通过适用性评估框架全面评估100%的禁烟法令在山东省实施的可行性。结果:目前的政治环境,利益相关者的反对是实施全面禁烟法令的最大障碍;财政资源、教育水平和社会接受度不太可能阻碍法令的实施;而人力资源和组织结构发挥的作用尚不明确。结论:目前要在山东省实施100%的禁烟法令尚有很大的难度。整个社会环境的变化,中国已经签署了世界卫生组织控烟框架,公众对吸烟越来越关注,这将会给未来法令的实施提供更有利的环境。 | 李文君 孟庆跃 Nicole Au | 2009 | 中国卫生事业管理2009，26，4： | 7 |
| 13 | Expansion of China's free antiretroviral treatment program显示文摘 | ZHAO De-cai WEN Yi MA Ye ZHAO Yan ZHANG Yao WU Ya-song LIU Xia Elizabeth Au LIU Zhong-fu ZHANG Fu-jie | 2012 | Chinese Medical Journal2012，，19： | 7 |
| 14 | MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic effects on cell motility显示文摘MicroRNAs (miRNAs ) ,小非编码的 RNA 的一个重要的班,在 post-transcriptional 水平调整基因表示。miRNAs 涉及大量生物过程并且在不同疾病含有,包括癌症。在这研究, miRNA 介绍和 qRT-PCR 确认揭示了那 miR-142-3p, miR-142-5p 是当疾病进行了,显著地,在 hepatocellular 癌(HCC ) 和他们的表示层次的 downregulated 减少了。miR-142 的宫外的表达式显著地减少了 HCC 房间移植和侵略。miR-142-3p 或 miR-142-5p 的 Overexpression 压制了 HCC 房间移植,并且两个的 overexpression synergistically 禁止了房间移植,它显示 miR-142-3p 和 miR-142-5p 可以合作地调整房间运动。因为他们的不同种子序列, miR-142-3p 和 miR-142-5p,是从先锋 miR-142 的 3' 海滨和 5'-strands 导出的成熟 miRNAs,指向基因的不同水池。小径丰富分析与几个房间显示出 miR-142-3p 和 miR-142-5p 的通常认为的基因目标的一个强壮的协会联系活动性的小径包括那些调整肌动朊细胞骨架, adherens 连接,和焦点的粘附。重要地,很多通常认为的基因目标也是显著地在人的 HCC 房间的 upregulated。而且, miR-142 的 overexpression 显著地在 HCC 房间废除了压力纤维形成并且导致了房间收缩。这研究证明成熟 miR-142 对联合地调整不同发信号的串联的不同部件因此影响 HCC 房间的活动性。 | Felice Ho-Ching Tsang Sandy Leung-Kuen Au Lai Wei Dorothy Ngo-Yin Fan Joyce Man-Fong Lee Carmen Chak-Lui Wong Irene Oi-Lin Ng Chun-Ming Wong | 2015 | Frontiers of Medicine2015，9，3： | 7 |
| 15 | Longitudinal Flight Dynamic Analysis on Vertical Takeoff of a Tailless Flapping-Wing Micro Air Vehicle显示文摘 | Loan Thi Kim Au Vu Hoang Phan Hoon Cheol Park | 2018 | Journal of Bionic Engineering2018，15，2： | 6 |
| 16 | Determination of site-specific soil-water characteristic curve from a limited number of test data-A Bayesian perspective显示文摘Determining soilewater characteristic curve(SWCC) at a site is an essential step for implementing unsaturated soil mechanics in geotechnical engineering practice, which can be measured directly through various in-situ and/or laboratory tests. Such direct measurements are, however, costly and timeconsuming due to high standards for equipment and procedural control and limits in testing apparatus. As a result, only a limited number of data points(e.g., volumetric water content vs. matric suction)on SWCC at some values of matric suction are obtained in practice. How to use a limited number of data points to estimate the site-specific SWCC and to quantify the uncertainty(or degrees-of-belief) in the estimated SWCC remains a challenging task. This paper proposes a Bayesian approach to determine a site-specific SWCC based on a limited number of test data and prior knowledge(e.g., engineering experience and judgment). The proposed Bayesian approach quantifies the degrees-of-belief on the estimated SWCC according to site-specific test data and prior knowledge, and simultaneously selects a suitable SWCC model from a number of candidates based on the probability logic. To address computational issues involved in Bayesian analyses, Markov Chain Monte Carlo Simulation(MCMCS), specifically Metropolis-Hastings(M-H) algorithm, is used to solve the posterior distribution of SWCC model parameters, and Gaussian copula is applied to evaluating model evidence based on MCMCS samples for selecting the most probable SWCC model from a pool of candidates. This removes one key limitation of the M-H algorithm, making it feasible in Bayesian model selection problems. The proposed approach is illustrated using real data in Unsaturated Soil Database(UNSODA) developed by U.S. Department of Agriculture. It is shown that the proposed approach properly estimates the SWCC based on a limited number of site-specific test data and prior knowledge, and reflects the degrees-of-belief on the estimated SWCC in a rational and quantitative manner. | Lin Wang Zi-Jun Cao Dian-Qing Li Kok-Kwang Phoon Siu-Kui Au | 2018 | Geoscience Frontiers2018，9，6： | 6 |
| 17 | Hydrothermal fabrication and visible-light-driven photocatalytic properties of bismuth vanadate with multiple morphologies and/or porous structures for Methyl Orange degradation显示文摘Monoclinic BiVO4 with multiple morphologies and/or porous structures were fabricated using the hydrothermal strategy. The materials were characterized by means of the XRD, Raman, TGA/DSC, SEM, XPS, and UV-Vis techniques. The photocatalytic activities of the BiVO4 materials were evaluated for the degradation of Methyl Orange under visible-light irradiation. It is observed that pH value and surfactant exerted a great effect on the morphology and pore structure of the BiVO4 product. Spherical BiVO4 with porous structures, flower-cluster-like BiVO4, and flower-bundle-like BiVO4 were generated hydrothermally at 100°C with poly(vinyl pyrrolidone) (PVP) and urea (pH = 2) and at 160°C with NaHCO3 (pH = 7 and 8), respectively. The PVP-derived BiVO4 showed much higher surface areas (5.0-8.4 m2/g) and narrower bandgap energies (2.45-2.49 eV). The best photocatalytic performance of the spherical BiVO4 material with a surface area of 8.4 m2/g was associated with its higher surface area, narrower bandgap energy, higher surface oxygen vacancy density, and unique porous architecture. | Haiyan Jiang Hongxing Dai Xue Meng Lei Zhang Jiguang Deng Yuxi Liu Chak Tong Au | 2012 | Journal of Environmental Sciences2012，24，3： | 5 |
| 18 | 气相色谱-质谱联用法检测新生儿脐带血多溴联苯醚显示文摘目的:建立新生儿脐带血中多溴联苯醚的分析方法。方法:血液样品采用离心和分离,提取血清并经正己烷和甲基叔丁基醚混合溶液萃取,萃取前加入回收率指示物,然后经干燥得到脂肪质量,脂肪再经正己烷溶解、硫酸酸洗和酸性硅胶柱净化后,加内标,利用带负化学源的气相色谱-质谱联用仪,采用选择离子检测法和内标法进行定性和定量。结果:加标回收率78.0%~110.0%;样品回收率82.3%;方法检出限0.01~0.09 ng。结论:该法检测电子垃圾拆解区新生儿脐带血中7种多溴联苯醚的同系物,灵敏度高、重复性好、回收率良好。 | 吴库生 郭勇勇 刘俊晓 徐锡金 W W Au 邵国 霍霞 | 2009 | 汕头大学医学院学报2009，22，2： | 5 |
| 19 | Attenuation of arsenic in a karst subterranean stream and correlation with geochemical factors: A case study at Lihu,South China显示文摘Arsenic(As) pollutants generated by human activities in karst areas flow into subterranean streams and contaminate groundwater easily because of the unique hydrogeological characteristics of karst areas. To elucidate the reaction mechanisms of arsenic in karst subterranean streams, physical–chemical analysis was conducted by an inductively coupled plasma mass spectrometer and an X-ray fluorescence spectrometer. The results show that inorganic species account for most of the total arsenic, whereas organic arsenic is not detected or occurs in infinitesimal amounts. As(III) accounts for 51.0% ± 9.9% of the total inorganic arsenic. Arsenic attenuation occurs and the attenuation rates of total As,As(III) and As(V) in the Lihu subterranean stream are 51%, 36% and 59%, respectively. To fully explain the main geochemical factors influencing arsenic attenuation, SPSS 13.0 and CANOCO 4.5 bundled with Cano Draw for Windows were used for simple statistical analysis and redundancy analysis(RDA). Eight main factors, i.e., sediment iron(SFe), sediment aluminum(SAl), sediment calcium(SCa), sediment organic matter(SOM), sediment manganese(SMn), water calcium(WCa2+), water magnesium(WMg2+), and water bicarbonate ion(WHCO3-) were extracted from thirteen indicators. Their impacts on arsenic content rank as: SFe > SCa > WCa2+> SAl > WHCO3-> SMn > SOM > WMg2+. Of these factors, SFe, SAl, SCa, SOM, SMn, WMg2+and WCa2+promote arsenic attenuation, whereas WHCO3-inhibits it. Further investigation revealed that the redox potential(Eh) and p H are adverse to arsenic removal. The dramatic distinction between karst and non-karst terrain is that calcium and bicarbonate are the primary factors influencing arsenic migration in karst areas due to the high calcium concentration and alkalinity of karst water. | Liankai Zhang Hui Yang Jiansheng Tang Xiaoqun Qin Au Yik Yu | 2014 | Journal of Environmental Sciences2014，26，11： | 5 |
| 20 | Minimally invasive donor hepatectomy, are we ready for prime time?显示文摘Minimally invasive surgery potentially reduces operative morbidities. However, pure laparoscopic approaches to donor hepatectomy have been limited by technical complexity and concerns over donor safety. Reducedwound donor hepatectomy, either in the form of a laparoscopic-assisted technique or by utilizing a minilaparotomy wound, i.e., hybrid approach, has been developed to bridge the transition to pure laparoscopic donor hepatectomy, offering some advantages of minimally invasive surgery. To date, pure laparoscopic donor left lateral sectionectomy has been validated for its safety and advantages and has become the standard in experienced centres. Pure laparoscopic approaches to major left and right liver donation have been reported for their technical feasibility in expert hands. Robotic-assisted donor hepatectomy also appears to be a valuable alternative to pure laparoscopic donor hepatectomy, providing additional ergonomic advantages to the surgeon. Existing reports derive from centres with tremendous experience in both laparoscopic hepatectomy and donor hepatectomy. The complexity of these procedures means an arduous transition from technical feasibility to reproducibility. Donor safety is paramount in living donor liver transplantation. Careful donor selection and adopting standardized techniques allow experienced transplant surgeons to safely accumulate experience and acquire proficiency. An international prospective registry will advance the understanding for the role and safety of pure laparoscopic donor hepatectomy. | Kin Pan Au Kenneth Siu Ho Chok | 2018 | World Journal of Gastroenterology2018，24，25： | 5 |
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