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| 1 | Efficacy and safety of treatment of hepatitis C virus infection in renal transplant recipients显示文摘AIM: To assess the efficacy and safety of combinedpegylated interferon and ribavirin therapy in hepatitis C virus (HCV) infection in renal transplant recipients. METHODS: This is a retrospective chart review of post renal transplant patients who were positive for anti-HCV and HCV-RNA, and who have received treatment with combination of pegylated interferon and ribavirin between October 2003 and December 2008. Only patients with stable graft function and absence of evidence of cirrhosis and who received the therapy for continuous 48 wk were included. Nineteen patients (13 male and 6 female) were identified and included. The patient's complete blood count, liver and kidney prof ile, and cal- culated glomerular f iltration rate (GFR) were monitored every 6-8 wk while on treatment. HCV-RNA was tested at 12 wk for early virological response, at 48 wk for end of treatment response (ETR), and then retested at 24, and 48 wk after completion of therapy for sustained virological response (SVR). Liver biopsies were obtained before treatment from all patients and graft kidney biopsies were performed as required. RESULTS: Of the entire cohort, 9 patients (47.4%) showed an ETR and 8 had SVR (42.1%). Of the 8 patients with abnormal alanine aminotransferase (ALT) levels at baseline, 78.9% had their ALT normalized (including the virological non responders). ALT was normal in all responders at the end of therapy and at 24 wk post therapy (100%). Only one patient (5.3%) developed an increase in creatinine and decline in GFR from baseline towards the end of treatment. This patient's kidney biopsy revealed borderline rejection. There was no impact on response by HCV-genotype, initial HCV RNA load, age or sex of the patient or duration post transplant before commencement of therapy. All patients tolerated treatment in the same way as non-transplant with no unusual or increased occurrence of side effects. CONCLUSION: The combination of pegylated interferon and ribavirin is effective in suppressing HCV-RNA,with a low risk of graft rejection or failure in HCV infected renal transplant recipients. | Abdulrahman A Aljumah Mohamed A Saeed Ahmed I Al Flaiw Ibrahim H Al Traif Abduljaleel M Al Alwan Salem H Al Qurashi Ghormallah A Al Ghamdi Fayez F Al Hejaili Mohammed A Al Balwi Abdulla A Al Sayyari | 2012 | World Journal of Gastroenterology2012，18，1： | 2 |
| 2 | Effect of Polyurethane Foam on the Energy Management of Structural Components显示文摘 | Alwan J M Wu Chi-chin Chou C C | 2000 | SAE2000，，： | 1 |
| 3 | Fascin is a key regulator of breast cancer invasion that acts via the modification of metastasis-associated molecules显示文摘 | AI Alwan M Olabi S Ghebeh H | 2011 | PLoS One2011，6，27： | 1 |
| 4 | Perificutin and properties of carboxypepridase-G2 from pseudomonas strain RS-16显示文摘 | SHERWOOD R F MELTON R G ALWAN S M | 1985 | Eur J Biochem1985，148，3： | 1 |
| 5 | Steady-state analysis of continuousdaptation in acoustic feedback reduction systems for hearing aids显示文摘 | SIQUEIRA M G ALWAN A | 2000 | Speech Audio Processing2000，，8： | 1 |
| 6 | Effect of mechanical clamping on the pull-out response of hooked steel fibers embedded in cementitious composites显示文摘 | Alwan J M Naaman A E | 1999 | Concrete Science and Engineering1999，1，3： | 1 |
| 7 | Bias temperature instability from gate charge characteristics investigations in n- channel power MOSFET显示文摘 | ALWAN M BEYDOUN B KETATA K | 2007 | Microelectronics Journal2007，38，67： | 1 |
| 8 | Exponential stability of singularly per- turbed switched systems with time delay 显示文摘 | Alwan M Liu X Z Ingalls B | 2008 | Nonlinear Analysis : Hybrid Systems2008，2，3： | 1 |
| 9 | Lightweigbt steel technology used in a vehicle design: Safety CAE analysis显示文摘 | Alwan J M | 2001 | American Society of Mechanical Engineers Applied Mechanics Division2001，250，： | 1 |
| 10 | Fiber puilout and slip Ⅰ : Analytical study显示文摘 | NAAMAN A E NAMUR G G ALWAN J M | 1991 | Journal of Structural Engineering1991，117，9： | 1 |
| 11 | The effect of gamma irradiation on the viscosity of two barley cultivars for broiler chicks 显示文摘 | A1-Kaisey M T Mohammed M A Alwan A K | 2002 | P _adiat Phys Chem2002，63，： | 1 |
| 12 | Thermochemical characterization of phenolic resins 显示文摘 | RAO M R ALWAN S SCARIAH K J | 1997 | Journal of Thermal Analysis and Calorimetry1997，49，1： | 1 |
| 13 | Health-status monitoring through analysis of behavioral patterns显示文摘 | Barger T.S Brown D.E Alwan M | | 0，，01： | 1 |
| 14 | Phenotypic and functional characterization of T cell lines specific for individual respiratory syncytial virus proteins显示文摘 | Alwan W H Record F M Openshaw P J | 1993 | J Immunol1993，150，： | 1 |
| 15 | Development and preliminary validation of heart rate and breathing rate detection using a passive,ballistocardiography-based sleep monitoring system显示文摘 | MACK D C PATRIE J T SURATT P M FELDER R A ALWAN M | 2009 | IEEE Transactions on Information Technology in Biomedicine2009，13，1： | 1 |
| 16 | Bias temperature instability from gate charge characteristics investigations in n-channel power MOSFET显示文摘 | ALWAN M BEYDOUN B KETATA K | 2007 | Microelec J2007，，38： | 1 |
| 17 | Bias temper- ature instability from gate charge characteristics investiga- tion in N-channel power MOSFET 显示文摘 | ALWAN M BEYDOUN B KETATA K | 2007 | Microelectronics2007，38，67： | 1 |
| 18 | Phenotypic and functional characterization of T cell lines specific for individual respiratory syncytial virus proteins显示文摘 | Alwan W H Record F M Openshaw P J | 1993 | J Immunol1993，150，： | 1 |
| 19 | Cerebral metabolic altera- tions and cognitive dysfunction in chronic kidney disease显示文摘 | Tryc A B Alwan G Bokemeyer M | 2011 | Neph tol Dial Transplant2011，26，8： | 1 |
| 20 | Local recurrence in patients wifll synchronous or metaehronous colorectal liver metastases-is there a difference? 显示文摘 | Alwan M Stubbs R | 2005 | N Z Med J2005，118，1221： | 1 |
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