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| 1 | Progression of diethylnitrosamine-induced hepatic carcinogenesis in carnitine-depleted rats显示文摘AIM:To investigate whether carnitine deficiency is a risk factor during the development of diethylnitrosamine (DENA)-induced hepatic carcinogenesis. METHODS:A total of 60 male Wistar albino rats were divided into six groups with 10 animals in each group.Rats in group 1(control group)received a single intraperitoneal(i.p.)injection of normal saline. Animals in group 2(carnitine-supplemented group) were given L-carnitine(200 mg/kg per day)in drinking water for 8 wk.Animals in group 3(carnitine-depleted group)were given D-carnitine(200 mg/kg per day)and mildronate(200 mg/kg per day)in drinking water for 8 wk.Rats in group 4(DENA group)were injected with a single dose of DENA(200 mg/kg,i.p.)and 2 wk later received a single dose of carbon tetrachloride(2 mL/kg) by gavage as 1:1 dilution in corn oil.Animals in group 5(DENA-carnitine depleted group)received the same treatment as group 3 and group 4.Rats in group 6 (DENA-carnitine supplemented group)received the same treatment as group 2 and group 4.RESULTS:Administration of DENA resulted in a significant increase in alanine transaminase(ALT), gamma-glutamyl transferase(G-GT),alkaline phosphatase(ALP),total bilirubin,thiobarbituric acid reactive substances(TBARS)and total nitrate/ nitrite(NOx)and a significant decrease in reduced glutathione(GSH),glutathione peroxidase(GSHPx), catalase(CAT)and total carnitine content in liver tissues.In the carnitine-depleted rat model,DENA induced a dramatic increase in serum ALT,G-GT,ALP and total bilirubin,as well as a progressive reduction in total carnitine content in liver tissues.Interestingly, L-carnitine supplementation resulted in a complete reversal of the increase in liver enzymes,TBARS and NOx,and a decrease in total carnitine,GSH,GSHPx, and CAT induced by DENA,compared with the control values.Histopathological examination of liver tissues confirmed the biochemical data,where L-carnitine prevented DENA-induced hepatic carcinogenesis while D-carnitine-mildronate aggravated DENA-induced hepatic damage. CONCLUSION:Data from this study suggest for the first time that:(1)carnitine deficiency is a risk factor and should be viewed as a mechanism in DENA- induced hepatic carcinogenesis;(2)oxidative stress plays an important role but is not the only cause of DENA-induced hepatic carcinogenesis;and(3) long-term L-carnitine supplementation prevents the development of DENA-induced liver cancer. | Salim S Al-Rejaie Abdulaziz M Aleisa Abdulaziz A Al-Yahya Saleh A Bakheet Abdulmalik Alsheikh Amal G Fatani Othman A Al-Shabanah Mohamed M Sayed-Ahmed | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 2 | Mutations in SUPPRESSOR OF VAR- IEGATION 1, a factor required for normal chloroplast translation, suppress var2-mediated leaf variegation in Arabidopsis 显示文摘 | Yu F Liu X Alsheikh M | 2008 | Plant Cell2008，20，7： | 1 |
| 3 | Prospectiveobservational studies of the management and outcomes inpatients with atrial fibrillation:a systematic review 显示文摘 | Hersi AS Alsheikh -Ali AA’Zubaid M | 2012 | JSaud Heart Assoc2012，24，4： | 1 |
| 4 | Presentation of systemic lupus erythematosus in emergency department显示文摘 | Waseem M Alsheikh M Hana A | 2007 | Pediatr Emerg Care2007，23，4： | 1 |
| 5 | Ion binding properties of the dehydrin ERD14 are dependent upon phosphorylation显示文摘 | Alsheikh M K Heyen B J Randall S K | | 0，，： | 1 |
| 6 | Phos- phorylation regulated ion-binding is a property shared by the acidic subclass dehydrins 显示文摘 | ALSHEIKH M K SVENSSON J T RANDALL S K | 2005 | Plant Cell & Environment2005，28，9： | 1 |
| 7 | The calcium-binding activity of a vacuole-associated,dehydrin-like protein is regulated by phosphorylation显示文摘 | Heyen B J Alsheikh M K Smith E A Torvik C F Seals D F Randall S K | | 0，，： | 1 |
| 8 | Phosphoryla- tion regulated ion-binding is a property shared by the a- cidic subclass dehydrins 显示文摘 | Alsheikh M K Svensson J T Randall S K | 2005 | Plant Cell and Environ- ment2005，28，9： | 1 |
| 9 | Phosphorylation regulated ion-binding is a property shared hy the acidic subclass dehydrins显示文摘 | Alsheikh M K Svensson J T Randall S K | 2005 | Plant Cell Environ2005，28，9： | 1 |
| 10 | Ion binding properties of the dehydrin ERD14 are dependent upon phosphorylation显示文摘 | Alsheikh M K Heyen B J Randall S K | 2003 | J Biol Chem2003，278，40： | 1 |
| 11 | Novel coronavirus infections in Jordan, April 2012: epidemiological findings from a retrospective investigation 显示文摘 | Hijawi B Abdallat M Sayaydeh A Alqasrawi S Haddadin A Jaarour N Alsheikh S Alsanouri T | 2013 | East Mediterr Health J2013，19，1： | 1 |
| 12 | Ion binding properties of the dehydrin erdl4 are dependent upon phospho- rylation 显示文摘 | ALSHEIKH M K HEYEN B J RANDALL S K | 2003 | The Journal of Biological Chemistry2003，17，40： | 1 |
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