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| 1 | Progression of diethylnitrosamine-induced hepatic carcinogenesis in carnitine-depleted rats显示文摘AIM:To investigate whether carnitine deficiency is a risk factor during the development of diethylnitrosamine (DENA)-induced hepatic carcinogenesis. METHODS:A total of 60 male Wistar albino rats were divided into six groups with 10 animals in each group.Rats in group 1(control group)received a single intraperitoneal(i.p.)injection of normal saline. Animals in group 2(carnitine-supplemented group) were given L-carnitine(200 mg/kg per day)in drinking water for 8 wk.Animals in group 3(carnitine-depleted group)were given D-carnitine(200 mg/kg per day)and mildronate(200 mg/kg per day)in drinking water for 8 wk.Rats in group 4(DENA group)were injected with a single dose of DENA(200 mg/kg,i.p.)and 2 wk later received a single dose of carbon tetrachloride(2 mL/kg) by gavage as 1:1 dilution in corn oil.Animals in group 5(DENA-carnitine depleted group)received the same treatment as group 3 and group 4.Rats in group 6 (DENA-carnitine supplemented group)received the same treatment as group 2 and group 4.RESULTS:Administration of DENA resulted in a significant increase in alanine transaminase(ALT), gamma-glutamyl transferase(G-GT),alkaline phosphatase(ALP),total bilirubin,thiobarbituric acid reactive substances(TBARS)and total nitrate/ nitrite(NOx)and a significant decrease in reduced glutathione(GSH),glutathione peroxidase(GSHPx), catalase(CAT)and total carnitine content in liver tissues.In the carnitine-depleted rat model,DENA induced a dramatic increase in serum ALT,G-GT,ALP and total bilirubin,as well as a progressive reduction in total carnitine content in liver tissues.Interestingly, L-carnitine supplementation resulted in a complete reversal of the increase in liver enzymes,TBARS and NOx,and a decrease in total carnitine,GSH,GSHPx, and CAT induced by DENA,compared with the control values.Histopathological examination of liver tissues confirmed the biochemical data,where L-carnitine prevented DENA-induced hepatic carcinogenesis while D-carnitine-mildronate aggravated DENA-induced hepatic damage. CONCLUSION:Data from this study suggest for the first time that:(1)carnitine deficiency is a risk factor and should be viewed as a mechanism in DENA- induced hepatic carcinogenesis;(2)oxidative stress plays an important role but is not the only cause of DENA-induced hepatic carcinogenesis;and(3) long-term L-carnitine supplementation prevents the development of DENA-induced liver cancer. | Salim S Al-Rejaie Abdulaziz M Aleisa Abdulaziz A Al-Yahya Saleh A Bakheet Abdulmalik Alsheikh Amal G Fatani Othman A Al-Shabanah Mohamed M Sayed-Ahmed | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 2 | Major-effect candidate genes identified in cultivated strawberry(Fragaria×ananassa Duch.)for ellagic acid deoxyhexoside and pelargonidin-3-O-malonylglucoside biosynthesis,key polyphenolic compounds显示文摘Strawberries are rich in polyphenols which impart health benefits when metabolized by the gut microbiome,including anti-inflammatory,neuroprotective,and antiproliferative effects.In addition,polyphenolic anthocyanins contribute to the attractive color of strawberry fruits.However,the genetic basis of polyphenol biosynthesis has not been extensively studied in strawberry.In this investigation,ripe fruits from three cultivated strawberry populations were characterized for polyphenol content using HPLC-DAD-MSn and genotyped using the iStraw35k array.GWAS and QTL analyses identified genetic loci controlling polyphenol biosynthesis.QTL were identified on four chromosomes for pelargonidin-3-O-malonylglucoside,pelargonidin-3-O-acetylglucoside,cinnamoyl glucose,and ellagic acid deoxyhexoside biosynthesis.Presence/absence of ellagic acid deoxyhexoside and pelargonidin-3-O-malonylglucoside was found to be under the control of major gene loci on LG1X2 and LG6b,respectively,on the F.×ananassa linkage maps.Interrogation of gene predictions in the F.vesca reference genome sequence identified a single candidate gene for ellagic acid deoxyhexoside biosynthesis,while seven malonyltransferase genes were identified as candidates for pelargonidin-3-O-malonylglucoside biosynthesis.Homologous malonyltransferase genes were identified in the F.×ananassa‘Camarosa’genome sequence but the candidate for ellagic acid deoxyhexoside biosynthesis was absent from the‘Camarosa’sequence.This study demonstrated that polyphenol biosynthesis in strawberry is,in some cases,under simple genetic control,supporting previous observations of the presence or absence of these compounds in strawberry fruits.It has also shed light on the mechanisms controlling polyphenol biosynthesis and enhanced the knowledge of these biosynthesis pathways in strawberry.The above findings will facilitate breeding for strawberries enriched in compounds with beneficial health effects. | Jahn Davik Kjersti Aaby Matteo Buti Muath Alsheikh NadaŠurbanovski Stefan Martens Dag Røen Daniel James Sargent | 2020 | Horticulture Research2020，7，1： | 2 |
| 3 | Mutations in SUPPRESSOR OF VAR- IEGATION 1, a factor required for normal chloroplast translation, suppress var2-mediated leaf variegation in Arabidopsis 显示文摘 | Yu F Liu X Alsheikh M | 2008 | Plant Cell2008，20，7： | 1 |
| 4 | Prospectiveobservational studies of the management and outcomes inpatients with atrial fibrillation:a systematic review 显示文摘 | Hersi AS Alsheikh -Ali AA’Zubaid M | 2012 | JSaud Heart Assoc2012，24，4： | 1 |
| 5 | Presentation of systemic lupus erythematosus in emergency department显示文摘 | Waseem M Alsheikh M Hana A | 2007 | Pediatr Emerg Care2007，23，4： | 1 |
| 6 | Patent foramen ovale in eryptogenic stroke : incidental or pathogenic? 显示文摘 | Alsheikh Ali AA Thaler DE Kent DM | 2009 | Stroke2009，40，7： | 1 |
| 7 | Adverse events with concomitant use of simvastatin or atorvastatin and thiazolidinediones显示文摘 | Alsheikh - Ali AA Karas RH | 2004 | Am J Cardiol2004，93，11： | 1 |
| 8 | Ion binding properties of the dehydrin ERD14 are dependent upon phosphorylation显示文摘 | Alsheikh M K Heyen B J Randall S K | | 0，，： | 1 |
| 9 | Phos- phorylation regulated ion-binding is a property shared by the acidic subclass dehydrins 显示文摘 | ALSHEIKH M K SVENSSON J T RANDALL S K | 2005 | Plant Cell & Environment2005，28，9： | 1 |
| 10 | Three Readers, Three Languages, Three Texts: The Strategic Reading of Multilingual and Multiliterate Readers显示文摘 | Alsheikh N O | 2011 | The Reading Matrix2011，，11： | 1 |
| 11 | Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic agents 显示文摘 | Weizman Z Asli G Alsheikh A | 2005 | Pediatrics2005，115，： | 1 |
| 12 | The calcium-binding activity of a vacuole-associated,dehydrin-like protein is regulated by phosphorylation显示文摘 | Heyen B J Alsheikh M K Smith E A Torvik C F Seals D F Randall S K | | 0，，： | 1 |
| 13 | Prevalence of low high density lipoprotein cholesterol in patients with documented coronary heart disease or risk equiva lent and controlled low density lipoprotein cholesterol显示文摘 | Alsheikh Ali AA Lin JL Abourjaily P | | 0，，10： | 1 |
| 14 | Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic agents 显示文摘 | Weizman Z Asli G Alsheikh A | 2005 | Pediatrics2005，115，1： | 1 |
| 15 | Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic agents 显示文摘 | Weizman Z Asli G Alsheikh A | 2005 | Pediatrics2005，115，1： | 1 |
| 16 | Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic a- gents 显示文摘 | Weizman Z Asli G Alsheikh A | 2005 | Pediatrics2005，115，1： | 1 |
| 17 | Effect of Simvastatin and Atorvastatin on Serum Vitamin D and Bone Mineral Density in Hypercholesterolemic Patients: A Cross-Sectional Study显示文摘 | Abrar Thabit Abdullah Alhifany Razan Alsheikh Sameh Namnqani Ameen Al-Mohammadi Soha Elmorsy Mohammed Qari Mohammed Ardawi Salvatore Minisola | 2014 | Journal of Osteoporosis2014，，： | 1 |
| 18 | Comparison of the WHO/ISUP classification and cytokeratin 20 expression in predicting the behavior of low-Grade papillary urothelial tumors 显示文摘 | Alsheikh A Mohamedali Z Jones E | 2001 | Modern Pathology2001，14，4： | 1 |
| 19 | Statins and interstitial lung disease a systematic review of the literature and of food and drug adminis- tration adverse event reports 显示文摘 | Fernandez AB Kanas RH Alsheikh -Ali AA | 2008 | Chest2008，134，4： | 1 |
| 20 | Electron Temperature Measurement of Argon Focussed Plasma Based on Non-local Thermodynamic Equilibrium Model显示文摘 | M. Akel S. Alsheikh Salo C. S. Wong | 2013 | Journal of Fusion Energy2013，，3： | 1 |
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