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| 1 | 减少急性冠状动脉综合征和卒中患者求医的延误——美国心脏协会心血管护理委员会和卒中委员会的科学声明显示文摘在寻求急性冠状动脉综合征和卒中症状的治疗方面,患者延误是限制提供这些疾病的确定性治疗的主要因素。尽管数十年来的研究和公众教育活动一直旨在缩短患者延误时间,但大多数患者仍然不能及时求医。在本科学声明中,我们总结了以下证据:(1)证明早期治疗的益处;(2)描述患者延误问题的程度;(3)确定与患者延误及时求医有关的因素;(4)揭示当前减少患者延误措施的不足。最后,提出临床实践和今后研究的建议。 | Debra K. Moser Laura P. Kimble Mark J. Alberts Angelo Alonzo Janet B. Croft Kathleen Dracup Kelly R. Evenson Alan S. Go Mary M. Hand Rashmi U. Kothari George A. Mensah Dexter L. Morris Arthur M. Pancioli Barbara Riegel Julie Johnson Zerwic 李宏建 曲东锋 | 2006 | 国际脑血管病杂志2006，14，10： | 39 |
| 2 | Baseline effects of lysophosphatidylcholine and nerve growth factor in a rat model of sciatic nerve regeneration after crush injury显示文摘Schwann cells play a major role in helping heal injured nerves. They help clear debris, produce neurotrophins, upregulate neurotrophin receptors, and form bands of Büngner to guide the healing nerve. But nerves do not always produce enough neurotrophins and neurotrophin receptors to repair themselves. Nerve growth factor(NGF) is an important neurotrophin for promoting nerve healing and lysophosphatidylcholine(LPC) has been shown to stimulate NGF receptors(NGFR). This study tested the administration of a single intraneural injection of LPC(1 mg/mL for single LPC injection and 10 mg/mL for multiple LPC injections) at day 0 and one(day 7), two(days 5 and 7), or three(days 5, 7, and 9) injections of NGF(160 ng/mL for single injections and 80 ng/mL for multiple injections) to determine baseline effects on crush ed sciatic nerves in rats. The rats were randomly divided into four groups: control, crush, crush-NGF, and crush-LPC-NGF. The healing of the nerves was measured weekly by monitoring gait; electrophysiological parameters: compound muscle action potential(CMAP) amplitudes; and morphological parameters: total fascicle areas, myelinated fiber counts, fiber densities, fiber packing, and mean g-ratio values at weeks 3 and 6. The crush, crush-NGF, and crush-LPC-NGF groups statistically differed from the control group for all six weeks for the electrophysiological parameters but only differed from the control group at week 3 for the morphological parameters. The crush, crush-NGF, and crush-LPC-NGF groups did not differ from each other over the course of the study. Single injections of LPC and NGF one week apart or multiple treatments of NGF at 5, 7 and 9 days post-injury did not alter the healing rate of the sciatic nerves during weeks 1-6 of the study. These findings are important to define the baseline effects of NGF and LPC injections, as part of a larger effort to determine the minimal dose regimen of NGF to regenerate peripheral nerves. | Ryan L.Wood Keaton S.Karlinsey Austin D.Thompson Mark N.Rigby Greggory D.Boatright William G.Pitt Beverly L.Roeder Scott C.Steffensen Alonzo D.Cook | 2018 | Neural Regeneration Research2018，13，5： | 5 |
| 3 | Notch signaling:Its essential roles in bone and craniofacial development显示文摘Notch is a cellecell signaling pathway that is involved in a host of activities including development,oncogenesis,skeletal homeostasis,and much more.More specifically,recent research has demonstrated the importance of Notch signaling in osteogenic differentiation,bone healing,and in the development of the skeleton.The craniofacial skeleton is complex and understanding its development has remained an important focus in biology.In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton,skull,and face develop.We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system,and what importance it may play in the future. | Mikhail Pakvasa Pranav Haravu Michael Boachie-Mensah Alonzo Jones Elam Coalson Junyi Liao Zongyue Zeng Di Wu Kevin Qin Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Yongtao Zhang Changchun Niu Meng Wu Xia Zhao Hao Wang Linjuan Huang Deyao Shi Qing Liu Na Ni Kai Fu Michael J.Lee Jennifer Moriatis Wolf Aravind Athiviraham Sherwin S.Ho Tong-Chuan He Kelly Hynes Jason Strelzow Mostafa El Dafrawy Russell R.Reid | 2021 | Genes & Diseases2021，8，1： | 4 |
| 4 | Fractures of the odontoid process of the axis显示文摘 | Anderson LD D' Alonzo RT | 1974 | J Bone Joint Surg (Am)1974，，56： | 1 |
| 5 | Apoptotic stress pat- hway ctivation mediated by iron on endothelial cells in vitro显示文摘 | Carlini RG Alonzo E Bellorin-Font E | 2006 | Nephrol Dial Transplant2006，21，11： | 1 |
| 6 | Gas exchange alterations following pulmonary thromboembolism显示文摘 | D' Alonzo GE Dantzker DR | | 0，，： | 1 |
| 7 | Ectopic pregnancy in a cesarean section scar treated with intramuscular methotrexate and bilateral uterine artery embolization显示文摘 | Hois EL Hibbeln JF Alonzo MJ | 2008 | J Clin Ultrasound2008，36，2： | 1 |
| 8 | In vitro effects of capsaicin: antiarrhythmic and antiischemic activity 显示文摘 | Grover GJ Darbenzio RB | 1995 | Eur J Pharmacol1995，272，23： | 1 |
| 9 | Using the ROC curve for gauging treatment effect in clinical trials显示文摘 | Brumback LC Pepe MS Alonzo TA | 2006 | Stat Med2006，25，4： | 1 |
| 10 | Risk factors for benign prostatic hypertrophy显示文摘 | Porta M Fernandez E Alonzo J | 1994 | Am J Epidemiol1994，139，1： | 1 |
| 11 | DNA methylationbasedbiomarkers for early detection of non-small cell lung cancer:an update显示文摘 | Anglim PP Alonzo TA Laird-Offringa IA | 2008 | Mol Cancer2008，7，1： | 1 |
| 12 | Urban tree species mapping using hyperspectral and lidar data fusion显示文摘 | ALONZO M BOOKHAGEN B ROBERTS D A | 2014 | Remote Sensing of Enviroment2014，148，25： | 1 |
| 13 | Cheyne-Stokes respiration during sleep in congestive heart failure显示文摘 | Quaranta A J D'Alonzo G E Krachman S L | 1997 | Chest1997，111，： | 1 |
| 14 | Natural history of transient myeloproliferative disorder clinically diagnosed in Down syndrome neonates: A report from the Children's Oncology Group Study A2971 显示文摘 | Gamis AS Alonzo TA Gerbing RB | 2011 | Blood2011，118，26： | 1 |
| 15 | Effect of polymer type on the dissolution profile of amorphous solid dispersions con- taining felodipine 显示文摘 | KONNO H HANDA T ALONZO D E | 2008 | Eur J Pharm Biopharm2008，70，2： | 1 |
| 16 | DNA methylation-based biomarkers for early detection of non-small cell lung cancer: an update显示文摘 | Anglim P P Alonzo T A Laird-Offringa I A | 2008 | Mol Cancer2008，7，： | 1 |
| 17 | Residual disease detected by multidimensional flow cytometry signifies high relapse risk in patients with de novo acute myeloidleukemia: a report from Children's Oncology Group 显示文摘 | Loken MR Alonzo TA Pardo L | 2012 | Blood2012，120，8： | 1 |
| 18 | Survival in pa-tients with primary pulmonary hypertension显示文摘 | D * Alonzo GE Barst RJ Ayres SM | 1991 | Ann In-tern Med1991，115，5： | 1 |
| 19 | Arsenic Trioxide Is a Well Tolerated Consolidation Regimen in Children with NewlyDiagnosed Acute Promyelocytic Leukemia; Toxicity Results of the Children's Ontology Group AAML0631 Trial 显示文摘 | Kutny M A Alonzo T A Gerbing R B | 2014 | Blood2014，124，21： | 1 |
| 20 | Sleep in the intensive care unit显示文摘 | Krachman SL D' Alonzo GE Criner GJ | 1995 | Chest1995，107，6： | 1 |
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