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| 1 | Hepatitis B and immunosuppressive therapies for chronic inflammatory diseases: When and how to apply prophylaxis, with a special focus on corticosteroid therapy显示文摘Currently immunosuppressive and biological agentsare used in a more extensive and earlier way in patients with inflammatory bowel disease, rheumatic or dermatologic diseases. Although these drugs have shown a significant clinical benefit, the safety of these treatments is a challenge. Hepatitis B virus(HBV) reactivations have been reported widely, even including liver failure and death, and it represents a deep concern in these patients. Current guidelines recommend to preemptive therapy in patients with immunosuppressants in general, but preventive measures focused in patients with corticosteroids and inflammatory diseases are scarce. Screening for HBV infection should be done at diagnosis. The patients who test positive for hepatitis B surface antigen, but do not meet criteria for antiviral treatment must receive prophylaxis before undergoing immunosuppression, including corticosteroids at higher doses than prednisone 20 mg/d during more than two weeks. Tenofovir and entecavir are preferred than lamivudine because of their better resistance profile in long-term immunosuppressant treatments. There is not a strong evidence, to make a general recommendation on the necessity of prophylaxis therapy in patients with inflammatory diseases that are taking low doses of corticosteroids in short term basis or low systemic bioavailability corticosteroids such as budesonide or beclomethasone dipropionate. In these cases regularly HBV DNA monitoring is recommended, starting early antiviral therapy if DNA levels begin to rise. In patients with occult or resolved hepatitis the risk of reactivation is much lower, and excepting for Rituximab treatment, the prophylaxis is not necessary. | Pilar López-Serrano Elsa de la Fuente Briongos Elisa Carrera Alonso Jose Lázaro Pérez-Calle Conrado Fernández | 2015 | World Journal of Hepatology2015，7，3： | 4 |
| 2 | Diagnostic yield and clinical outcomes after capsule endoscopy in 100 consecutive patients with obscure gastrointestinal bleeding显示文摘 | Emilio Estévez Benito González-Conde José Luis Vázquez-Iglesias Maria de los Angeles Vázquez-Millán Sonia Pértega Pedro A. Alonso Joan Clofent Eva Santos José Luis Ulla Eloy Sánchez | 2006 | European Journal of Gastroenterology & Hepatology2006，，8： | 3 |
| 3 | Effect of Nd3+doping on structure,microstructure,lattice distortion and electronic properties of TiO_2 nanoparticles显示文摘Doped and undoped TiCh nanoparticles were prepared by Stober method and thermally treated at 600 ℃.The effect of Nd^(3+) ion on the structure and micro structure of anatase-phase TiCh nanocrystals was studied by Rietveld refinement method using X-ray powder diffraction data.Bond lengths,bond angles,and edges distances were analyzed.The phase formation was confirmed by high-resolution transmission electron microscopy.The adjustment of Ti-0 bond length induced by the addition of Nd^(3+) ions,reduced the octahedral distortion and altered the octahedral array in the anatase-phase TiCh nanocrystal.The changes of structure and microstructure were mainly observed for TiCh nanoparticles doped with 0.1 at.%of Nd^(3+) ions and attributed to the cationic substitution of Ti^(4+) ions which promoted changes in the density of states and gap band of TiCh.The dopant insertion resulted in a better structural stability of the nanocrystals that enhanced their charge transference and photocatalytic efficiency. | Balter Trujillo-Navarrete María del Pilar Haro-Vázquez Rosa María Félix-Navarro Francisco Paraguay-Delgado Henry Alvarez-Huerta Sergio Pérez-Sicairos Edgar Alonso Reynoso-Soto | 2017 | Journal of Rare Earths2017，35，3： | 2 |
| 4 | Nested PCR improves detection of infectious hematopoietic necrosis virus in cells coinfected with infectious pancreatic necrosis virus显示文摘 | Marta Alonso Sylvia Rodr??guez Sara I Pérez Prieto | 1999 | Journal of Virological Methods1999，，1： | 2 |
| 5 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 6 | Production of free conjugated linoleic acid by Lactobacillus acidophilus and Lactobacillus casei of human intestinal origin显示文摘 | ALONSO L CUESTA E P GILLILAND S E | 2003 | J Dairy Sci2003，86，6： | 1 |
| 7 | An improved time domain arc furnace model for harmonic analysis显示文摘 | ALONSO M A P DONSION M P | 2004 | IEEE Transactions on Power Delivery2004，19，1： | 1 |
| 8 | Contact pressures in the flexed hip joint during lateral trochanteric loading显示文摘 | Sparks D R Beason D P Etheridge B S Alonso J E Eberhardt A W | 2005 | J Orthop Res2005，23，： | 1 |
| 9 | A novelstrategy for radar imaging based on compressive sensing显示文摘 | Alonso M T López-Dekker P and MallorquíJ J | 2010 | IEEE Transactions on Geoscience and Remote Sensing2010，48，12： | 1 |
| 10 | A microsatellite fluo-rescent method for linkage analysis in familial retinobtastoma and de-letion detection at the RB 1 locus in retinobtastoma and osteosarcoma显示文摘 | Alonso J Gareia-Miguet P Abetairas J et at | 2001 | Diagn Mol Pathol2001，10，： | 1 |
| 11 | Role of universal 16S rRNA gene PCR and sequencing in diagnosis of prosthetic joint infection显示文摘 | Marin M Garcia-Lechuz JM Alonso P | 2012 | J Clin Microbiol2012，50，3： | 1 |
| 12 | Memory and strategic process- ing in first-degree relatives of obsessive-compulsive patients显示文摘 | Segalas C Alonso P Real E | 2010 | Psychol Med2010，40，12： | 1 |
| 13 | Bile duct reconstruction using 3-dimensional collagen tubes 显示文摘 | Pérez Alonso AJ Del Olmo Rivas C Machado Romero I | 2013 | Cir Esp2013，91，9： | 1 |
| 14 | Case report: sonographic apperance of cavernous hemangioma of testis 显示文摘 | Lozano V Alonso P Marcos-Robles J | 1994 | Clin Radiol1994，49，4： | 1 |
| 15 | Self - monitoring of oral anticoagulation : A systematic review and meta - analysis 显示文摘 | Heneghan C Alonso - Coello P Garcia - Alamino JM | 2006 | Lancet2006，367，9508： | 1 |
| 16 | Biogenic amine production by Oenococcus oeni isolates from malolactic fermentation of Tempranillo wine显示文摘 | IZQUIERDO-CANAS P M GOMEZ ALONSO S RUIZ PEREZ P | 2009 | Journal of Food Protection2009，72，4： | 1 |
| 17 | Real-time PCR designs to estimate nuclear and mitochondrial DNA copy number in fo- rensic and ancient DNA studies 显示文摘 | Alonso A Albarran C Garcia P | 2004 | Forensic Sei Int2004，139，23： | 1 |
| 18 | Crystal structure of the complete integrin alpha Vbeta3 ectodomain plus an alpha/beta transmembrane fragment显示文摘 | XIONG J P MAHALINGHAM B ALONSO J L | 2009 | J Cell Biol2009，186，4： | 1 |
| 19 | Microdialysis samping to determine the pharmacokinetics of unbound SDZ ICM 567 in blood and brain in awake,freely-moving rats显示文摘 | ALONSO M J BRUELISAUER A MISSIN P | 1995 | Pharm Res1995，12，2： | 1 |
| 20 | Multiplicity of solutions for elliptic problems with critical exponent or with a nonsymmetric term显示文摘 | AZORERO J P G ALONSO I P | 1991 | Tram Amer Math Soc1991，323，2： | 1 |
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