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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells显示文摘 | NELSON T J PHD M D ALMUDENA MARTINEZ -FERNANDEZ | 2009 | Circulation2009，120，： | 1 |
| 3 | The influence of lactic bacteria on the quality of malt显示文摘 | DEIRDRE P ELKE K ALMUDENA M | 2005 | J Inst Brew2005，111，： | 1 |
| 4 | Life cycle inventory of partiele- board: a case study in the woods sector显示文摘 | Beatriz R Almudena H Teresa M | 2006 | The International Journalof Life Cycle Assessment2006，11，2： | 1 |
| 5 | Atorvastatin Reduces the Expression of Prostaglandin E2 Receptors in Human Carotid Atherosclerotic Plaques and Monocytic Cells: Potential Implications for Plaque Stabilization显示文摘 | Almudena Gómez-Hernández Eva Sánchez-Galán José Luis Martín-Ventura Cristina Vidal Luis Miguel Blanco-Colio Mónica Ortego Melina Vega Javier Serrano Luis Ortega Gonzalo Hernández José Tunón Jesús Egido | 2006 | Journal of Cardiovascular Pharmacology2006，，1： | 1 |
| 6 | Application of lactic acid bacteria in malting and brewing显示文摘 | Helge M Ulmer Declan L Goode Almudena Soriano | 2004 | Brewers Digest2004，79，2： | 1 |
| 7 | Polymer microcapsules as mobile local pH-sensors 显示文摘 | Oliver K Almudena M J Gleb B S | 2007 | J Mater Chem2007，17，42： | 1 |
| 8 | J Chroma A显示文摘 | Almudena M U Jose M G S Consuelo P | 2005 | 1089(1-2):31-382005，1089，12： | 1 |
| 9 | Developmental and stress regulation of gene expression for a 9 - eis - epoxycarotenoid dioxygenase, CstNCED, isolated from Crocus sativus stigmas显示文摘 | Oussama A Angela R M Almudena T | 2012 | J Exp Bot2012，63，2： | 1 |
| 10 | Developmental and stress regulation of gene expression for a eis-epoxy carotenoid dioxygenase, CstNCED, isolated from Crocus sativus stigmas显示文摘 | Oussama A Angela R M Almudena T | 2012 | Journal of Experimental Botany2012，63，2： | 1 |
| 11 | The influence of lactic acid bacteria on the quality of malt 显示文摘 | Deirdre P Elke K Almudena M | 2005 | Journal of the Institute of Brewing2005，111，1： | 1 |
| 12 | Plasmid profiling and antibiotic resistance of Vibrio strains isolated from cultured penaeid shrimp 显示文摘 | ALMUDENA M A ALEJANDRA G G | 2002 | FEMS Microbiology Letters2002，213，1： | 1 |
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