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| 1 | Superoxide dismutase prevents development of adenocarcinoma in a rat model of Barrett's esophagus显示文摘AIM: To test whether antioxidant treatment could prevent the progression of Barrett's esophagus to adenocarcinoma.METHODS: In a rat model of gastroduodenoesophageal reflux by esophagojejunal anastomosis with gastric preservation, groups of 6-10 rats were randomized to receive treatment with superoxide dismutase (SOD) or vehicle and followed up for 4 mo. Rat's esophagus was assessed by histological analysis, superoxide anion and peroxinitrite generation, SOD levels and DNA oxidative damage.RESULTS: All rats undergoing esophagojejunostomy developed extensive esophageal mucosal ulceration and inflammation by mo 4. The process was associated with a progressive presence of intestinal metaplasia beyondthe anastomotic area (9% 1st mo and 50% 4th mo) (94% at the anastomotic level) and adenocarcinoma(11% 1st mo and 60% 4th mo). These changes were associated with superoxide anion and peroxinitrite mucosal generation, an early and significant increase of DNA oxidative damage and a significant decrease in SOD levels (P<0.05). Exogenous administration of SOD decreased mucosal superoxide levels, increased mucosal SOD levels and reduced the risk of developing intestinal metaplasia beyond the anastomotic area (odds ratio = 0.326; 95%CI: 0.108-0.981; P = 0.046),and esophageal adenocarcinoma (odds ratio = 0.243;95%CI: 0.073-0.804; P = 0.021).CONCLUSION: Superoxide dismutase prevents the progression of esophagitis to Barrett's esophagus and adenocarcinoma in this rat model of gastrointestinal reflux, supporting a role of antioxidants in the chemoprevention of esophageal adenocarcinoma. | Elena Piazuelo Carmelo Cebrián Alfredo Escartín Pilar Jiménez Fernando Soteras Javier Ortego Angel Lanas | 2005 | World Journal of Gastroenterology2005，11，47： | 5 |
| 2 | Farm-scale evaluation of the impact of CrylAb Bt maize on canopy nontarget arthropods: a 3-year study显示文摘 | Maria Arias-Martin Matias Garcia Pedro Castanera Felix Ortego Gema P. Farinos | 2018 | Insect Science2018，25，1： | 2 |
| 3 | 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors,atorvastatin and simvastatin,induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation显示文摘 | Blanco-Colio LM Villa A Ortego M | 2002 | Atherosclerosis2002，161，： | 1 |
| 4 | Glucosamine in-hibits IL-1beta induced NFkappaB activation in human os-teoarthritic chondrocytes显示文摘 | Largo R Alvarez Soria MA Diez Ortego I | 2003 | Osteoarthritis Cartilage2003，11，4： | 1 |
| 5 | Transmissible gastroenteritis coronavirus gene7 is not essential but influences in vivo virus replication and virulence 显示文摘 | Ortego J Sola I | 2003 | Virology2003，308，1： | 1 |
| 6 | 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors,atorvastatin and simvastatin,induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation显示文摘 | BLANCO-COLIO LM VILLA A ORTEGO M | 2002 | Atherosclerosis2002，161，1： | 1 |
| 7 | Possible role of parathyroid hormone-related protein as a proinflammatory cytokine in atherosclerosis 显示文摘 | Martin Ventura JL Ortego M Esbrit P | 2003 | Stroke2003，34，7： | 1 |
| 8 | Glucosamine inhibits IL-1 beta-induced NfkappaB activation in human osteoarthritic chondrocytes显示文摘 | Largo R Alvarez Soria MA Diez Ortego I | 2003 | Osteoarthritis Cartilage2003，11，4： | 1 |
| 9 | Atorvastatin reduces NF-κB activation and chemokine expression in vascular smooth cells and mononuclear cells显示文摘 | Ortego M Bustos C Hernandez-Presa MA Tunon J Diaz C Hernandez G | 1999 | Atherosclerosis1999，147，： | 1 |
| 10 | HMGCoA reduetase inhibitors reduce Ⅰ kappa B kinase activity induced by oxidative stress in monocytes and vascular smooth muscle cells显示文摘 | Ortego M Gomez-Hernandez A Vidal C | 2005 | J Cardiovasc Pharmacol2005，45，5： | 1 |
| 11 | Atorvastatin reduces NF-KB activation and chemokine expression in vascular smooth muscle cells and mononuclear cells显示文摘 | ORTEGO M BUSTOS C HERNANDEZ-PRESA M A | 1999 | Atherosclerosis1999，147，： | 1 |
| 12 | HMG-CoA reductase inhibition by atorvastatin reduces neointimal inflammation in a rabbit model of atherosclerosis显示文摘 | Bustos C Hernandez-Presa MA Ortego M | 1998 | J Am Coll Cardiol1998，32，7： | 1 |
| 13 | Stabilisation of low softening point petroleum pitch fibres by iodine treatment 显示文摘 | Ortego E V Monge J A Amoros D C | 2007 | Fuel Processing Technology2007，88，3： | 1 |
| 14 | Angiotensin converting enzyme inhibtor prevents arterial nuclear factor KB activation,monocytokine attractant protein 1 expression and macrophage infiltration in a rabbit model of early accelerated athe rosclerosis显示文摘 | HERNANDEZ-P RESA M BUSTOS C ORTEGO M | 1997 | Circulation1997，95，： | 1 |
| 15 | Or- ganization of two transmissible gastroenteritis coronavirus membrane protein topologies within the virion and core 显示文摘 | ESCORS D CAMAFEITA E ORTEGO J | 2001 | J Virol2001，75，12： | 1 |
| 16 | Glu- cosamine inhibits IL - 1 beta - induced NF - kappaB activa- tion in human osteoarthritic chondroeytes 显示文摘 | Largo R Alvarez Sofia MA Diez - Ortego I | 2003 | Osteoarthfitis Cartilage2003，11，4： | 1 |
| 17 | Atorvastatin reduces NF-kappaB activation and chemokine expression in vascular smooth muscle cells and mononuclear cells 显示文摘 | Ortego M Bustos C Hernandez-Presa MA | 1999 | Atherosclerosis1999，147，2： | 1 |
| 18 | Effects and interactions of endothelin-1 and angiotensin ii on matrix protein expression and synthesis and mesangial cell growth显示文摘 | Ruiz-Ortega M Ortego M Largo R LopezArmada M J Plaza JJ | 1996 | Hypertension1996，27，4： | 1 |
| 19 | Experimental oral infection of bluetongue virus serotype 8 in type I interferon receptor-deficient mice显示文摘 | Calvo-Pinilla E Nieto J M Ortego J | | 0，，： | 1 |
| 20 | Stabilisation of low softening point petroleum pitch fibres by HNO3显示文摘 | Ortego E V Monge J A Cazorla-Amoros D | 2003 | Carbon2003，41，10： | 1 |
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