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| 1 | Brugada type 1 electrocardiogram:Should we treat the electrocardiogram or the patient?显示文摘Patients with a Brugada type 1 electrocardiogram(ECG) pattern may suffer sudden cardiac death(SCD). Recognized risk factors are spontaneous type 1 ECG and syncope of presumed arrhythmic origin. Familial sudden cardiac death(f-SCD) is not a recognized independent risk factor. Finally, positive electrophysiologic study(+EPS) has a controversial prognostic value. Current ESC guidelines recommend implantable cardioverter defibrillator(ICD) implantation in patients with a Brugada type 1 ECG pattern if they have suffered a previous resuscitated cardiac arrest(class Ⅰrecommendation) or if they have syncope of presumed cardiac origin(class Ⅱa recommendation). In clinical practice, however, many other patients undergo ICD implantation despite the suggestions of the guidelines. In a 2014 cumulative analysis of the largest available studies(including over 2000 patients), we found that 1/3 of patients received an ICD in primary prevention. Interestingly, 55% of these latter were asymptomatic, while 80% had a + EPS. This means that over 30% of subjects with a Brugada type 1 ECG pattern were considered at high risk of SCD mainly on the basis of EPS, to which a class Ⅱb indication for ICD is assigned by the current ESC guidelines. Follow-up data confirm that in clinical practice single, and often frail, risk factors overestimate the real risk in subjects with the Brugada type 1 ECG pattern. We can argue that, in clinical practice, many cardiology centers adopt an aggressive treatment in subjects with a Brugada type 1 ECG pattern who are not at high risk. As a result, many healthy persons may be treated in order to save a few patients with a true Brugada Syndrome. Better risk stratification is needed. A multi-parametric approach that considers the contemporary presence of multiple risk factors is a promising one. | Pietro Delise Giuseppe Allocca Nadir Sitta | 2017 | World Journal of Cardiology2017，9，9： | 2 |
| 2 | Hypercholesterolaemia is not associated with early atherosclerotic lesions in primary biliary cirrhosis显示文摘 | Allocca M Crosignani A Gritti A Ghilardi G Gobatti D Caruso D | 2006 | Gut2006，55，： | 1 |
| 3 | Biodiesel/ mineral diesel fuel mixtures: Spray evolution and engine performance and emissions characterization 显示文摘 | Valentino G Allocca L Iannuzzi S | 2011 | Energy2011，36，6： | 1 |
| 4 | Arrhythmogenie right ventrieular dysplasia / urdiomyopathy as a cause of sudden infant death显示文摘 | NACIFORA G BENETTONI A ALLOCCA G | 2008 | J Cardiouase Med2008，9，4： | 1 |
| 5 | Arrhythmogenic right ventrieular dysplasia/cardiomyopathy as a cause of sudden infant death 显示文摘 | Nucifora G Benettoni A Allocca G | 2008 | J Cardiovasc Med2008，9，4： | 1 |
| 6 | Arrhythmogenic right ventricular dysplasia/cardiomyopathy as a cause of sudden infant death显示文摘 | Nucifora G Benettoni A Allocca G Bussani R Silvestri F | 2008 | J Cardiovasc Med2008，9，4： | 1 |
| 7 | Systemic but not intraocular Epo gene transfer protects the retina from light-and genetic-induced degeneration显示文摘 | Rex T S Allocca M Domenici L | 2004 | Mol Ther2004，10，： | 1 |
| 8 | Design analysis of single-sided natural ventilation显示文摘 | Allocca C Chen Q Glicksman L R | 2003 | Energy and Buildings2003，35，8： | 1 |
| 9 | Serotype-dependent packaging of large genes in adeno associated viral vectors results in effective gene delivery in mice 显示文摘 | Allocca M Doria M Petrillo M | 2008 | J Clin Invest2008，118，5： | 1 |
| 10 | Innovation speed in small and medium-size Enterprises 显示文摘 | Michael A Allocca Eric H Kessler | 2006 | Creativity and Innovation Management2006，15，3： | 1 |
| 11 | Experimental and numerical analysis of high pressure diesel spray-wall interaction显示文摘 | L Andreassi S Ubertini L Allocca | | 0，，： | 1 |
| 12 | Viral infections in inflammatory bowel disease:Tips and tricks for correct management显示文摘Over the past decades,the treatment of inflammatory bowel diseases(IBD)has become more targeted,anticipating the use of immune-modifying therapies at an earlier stage.This top-down approach has been correlated with favorable short and long-term outcomes,but it has also brought with it concerns regarding potential infectious complications.This large IBD population treated with immunemodifying therapies,especially if combined,has an increased risk of severe infections,including opportunistic infections that are sustained by viral,bacterial,parasitic,and fungal agents.Viral infections have emerged as a focal safety concern in patients with IBD,representing a challenge for the clinician:they are often difficult to diagnose and are associated with significant morbidity and mortality.The first step is to improve effective preventive strategies,such as applying vaccination protocols,adopt adequate prophylaxis and educate patients about potential risk factors.Since viral infections in immunosuppressed patients may present atypical signs and symptoms,the challenges for the gastroenterologist are to suspect,recognize and diagnose such complications.Appropriate treatment of common viral infections allows us to minimize their impact on disease outcomes and patients’lives.This practical review supports this standard of care to improve knowledge in this subject area. | Vincenzo Craviotto Federica Furfaro Laura Loy Alessandra Zilli Laurent Peyrin-Biroulet Gionata Fiorino Silvio Danese Mariangela Allocca | 2021 | World Journal of Gastroenterology2021，27，27： | 1 |
| 13 | Design analysis of single-sided natural ventilation显示文摘 | Camille Allocca Qingyan Chen Leon R Glicksman | 2003 | Energy and Buildings2003，35，： | 1 |
| 14 | Pilot study on the effects of high molecular weight sodium hyaluronate in the treatment of chronic pharyngitis显示文摘 | Leone CA Caruso AA Allocca V | 2015 | Int J Immunopathol Pharmacol2015，28，4： | 1 |
| 15 | Design analysis of single-sided natural ventilation显示文摘 | Allocca C Chen Q Glicksman LR | 2003 | Energy and Building2003，35，： | 1 |
| 16 | Ex- perimental and numerical analysis o{ high pressure diesel spray-wall interaction 显示文摘 | ANDRESSI L UBERTINI S ALLOCCA L | 2007 | lnt J of Multi- phase Flow2007，33，7： | 1 |
| 17 | Design analysis of single-sided natural ventilation显示文摘 | Camille Allocca Qingyan Chen Leon R Glicksman | 2002 | Energy & Buildings2002，，8： | 1 |
| 18 | Design analysis of single - sided natural ventilation显示文摘 | Allocca C Chen QY Glicksman LR | 2003 | Energy and Buildings2003，35，8： | 1 |
| 19 | Risk stratification in individuals with the Brugada type 1 ECG pattern without previous cardiac arrest: usefulness of a combined clinical and electrophysiologic approach 显示文摘 | DELISE P ALLOCCA G MARRAS E | 2011 | Eur Heart J2011，32，2： | 1 |
| 20 | Systemic but not intraocular Epo gene transfer protects thr retina from light and genetic induced degeneration显示文摘 | Rex TS Allocca M Domenicil L | 2004 | Mol Ther2004，10，： | 1 |
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