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| 1 | Next generation sequencing in cardiovascular diseases显示文摘In the last few years,the advent of next generation sequencing(NGS) has revolutionized the approach to genetic studies,making whole-genome sequencing a possible way of obtaining global genomic information.NGS has very recently been shown to be successful in identifying novel causative mutations of rare or common Mendelian disorders.At the present time,it is expected that NGS will be increasingly important in the study of inherited and complex cardiovascular diseases(CVDs).However,the NGS approach to the genetics of CVDs represents a territory which has not been widely investigated.The identification of rare and frequent genetic variants can be very important in clinical practice to detect pathogenic mutations or to establish a profile of risk for the development of pathology.The purpose of this paper is to discuss the recent application of NGS in the study of several CVDs such as inherited cardiomyopathies,channelopathies,coronary artery disease and aortic aneurysm.We also discuss the future utility and challenges related to NGS in studying the genetic basis of CVDs in order to improve diagnosis,prevention,and treatment. | Francesca Faita Cecilia Vecoli Ilenia Foffa Maria Grazia Andreassi | 2012 | World Journal of Cardiology2012，4，10： | 2 |
| 2 | tHistory of keratinocyte cultivation显示文摘 | Andreassi L | 1992 | Burns1992，18，： | 1 |
| 3 | Deoxyribonucleic acid damage in human lymphocytes after percutaneous transluminal coronary angioplasty显示文摘 | Andreassi MG Botto N Rizza A | 2002 | J Am Coll Cardiol2002，40，86： | 1 |
| 4 | Genetic polymorphisms in folate and homocysteine metabolism as risk factors for DNA damage 显示文摘 | Botto N Andreassi MG Manfredi S | 2003 | Eur J Hum Genet2003，11，9： | 1 |
| 5 | Autografts and cultured epidermis in the treatment of vitiligo 显示文摘 | Pianigiani E Andreassi A Andreassi L | 2005 | Clin Dermatol2005，23，4： | 1 |
| 6 | Hormone replacement therapy: one-year follow up of DNA damage 显示文摘 | Casella M Manfredi S Andreassi MG etc | 2005 | Mutat Res2005，585，： | 1 |
| 7 | Segmental phenolization for the treatment of ingrowing toenails:a review of 6 years experience显示文摘 | Andreassi A Grimaldi L D′Aniello C | 2004 | J Dermatolog Treat2004，15，3： | 1 |
| 8 | Endothelial nitric oxide synthase gene polymorphisms and riskof coronary artery disease显示文摘 | Colombo M G Paradossi U Andreassi M G | 2003 | Clin Chem2003，49，3： | 1 |
| 9 | Evidence for association of a common variant of the endothelial nitric oxide synthase gene (Glu298-> Asp polymorphism) to the presence, extent, and severity of coronary artery disease显示文摘 | Colombo MG Andreassi MG Paradossi U | 2002 | Heart2002，87，6： | 1 |
| 10 | Metabolic syndrome, diabetes and atherosclerosis: influence of gene-environment interaction 显示文摘 | Andreassi MG | 2009 | Muta Res2009，667，1： | 1 |
| 11 | Paclitaxel: a new antimitotic chemo- therapeutic agent显示文摘 | Gotaskie GE Andreassi BF | 1994 | Cancer Pract1994，2，1： | 1 |
| 12 | Evidence for association of a common variant of the endothelial nitric oxide synthase gene (Glu298→Asp polymorphism) to the presence,extent,and severity of coronary artery disease显示文摘 | Colombo MG Andreassi MG Paradossi U | 2002 | Heart2002，87，： | 1 |
| 13 | Cardiac catheterization and long-term chromosomal damage in children with congenital heart disease显示文摘 | Andreassi MG Ait-Ali L Botto N | 2006 | Eur Heart J2006，27，22： | 1 |
| 14 | Evidence for association of a common variant of the endothelial nitric oxide synthase gene (Glu^298→ Asp polymorphism) to the presence, extent,and severity of coronary artery disease显示文摘 | Colombo M G Andreassi M G Paradossi U | 2002 | Heart2002，87，6： | 1 |
| 15 | DNA Damage as a new emerging risk fac-tor in atherosclerosis显示文摘 | Andreassi MG Botto N | 2003 | Trends in Cardiovaseular Medieine2003，3，： | 1 |
| 16 | Antioxidant activ- ity of topically applied lycopene显示文摘 | Andreassi M Stanghellini E Ettorre A | 2004 | Eur Acad Dermatol Venereol2004，18，： | 1 |
| 17 | Management of techno- logical innovation: Case studies in bioteehnology com- panies in Brazil显示文摘 | Daniel Chu Tales Andreassi | 2011 | Management Research: The Jour- nal of the Iberoamerican Academy of Management2011，，09： | 1 |
| 18 | Subclinical carotid atherosclerosis and early vascular aging from long-term low-dose ionizing radiation exposure: a genetic, telomere, and vascular ultrasound study in cardiac catheterization laboratory staff显示文摘 | Andreassi MG Piccaluga E Gargani L | 2015 | JACC Cardiovasc Interv2015，8，4： | 1 |
| 19 | F-Endothelial nitric oxide synthase gene polymoqahisms and risk of coronary artery disease显示文摘 | Colombo MG Psradessi U Andreassi MG | 2003 | Clin Chem2003，49，3： | 1 |
| 20 | Cumulative patient effective dose and acute radiation-induced chromosomal DNA damage in children with congenital heart disease显示文摘 | Ait-Ali L Andreassi MG Foffa I | 2010 | Heart2010，96，4： | 1 |
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