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| 1 | Aqueous suspension of anise “Pimpinella anisum” protects rats against chemically induced gastric ulcers显示文摘AIM: To substantiate the claims of Unani and Arabian traditional medicine practitioners on the gastroprotective potential effect of a popular spice anise, 'Pimpinella anisum L.' on experimentally-induced gastric ulceration and secretion in rats. METHODS: Acute gastric ulceration in rats was produced by various noxious chemicals including 80% ethanol, 0.2 mol/L NaOH, 25% NaCl and indomethacin. Anti-secretory studies were undertaken using pylorus- ligated Shay rat technique. Levels of gastric non-protein sulfhydryls (NP-SH) and wall mucus were estimated and gastric tissue was also examined histologically. Anise aqueous suspension was used in two doses (250 and 500 mg/kg body weight) in all experiments. RESULTS: Anise significantly inhibited gastric mu- cosal damage induced by necrotizing agents and indomethacin. The anti-ulcer effect was further confirmed histologically. In pylorus-ligated Shay rats, anise suspension significantly reduced the basal gastric acid secretion, acidity and completely inhibited the rumenal ulceration. On the other hand, the suspension significantly replenished ethanol-induced depleted levels of gastric mucosal NP-SH and gastric wall mucus concentration. CONCLUSION: Anise aqueous suspension possesses significant cytoprotective and anti-ulcer activities against experimentally-induced gastric lesions. The anti-ulcer effect of anise is possibly prostaglandin-mediated and/orthrough its anti-secretory and antioxidative properties. | Ibrahim A Al Mofleh Abdulqader A Alhaider Jaber S Mossa Mohammed O Al-Soohaibani Syed Rafatullah | 2007 | World Journal of Gastroenterology2007，13，7： | 7 |
| 2 | Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression显示文摘 | Abdulqader A. Alhaider Hesham M. Korashy Mohamed M. Sayed-Ahmed Mohammed Mobark Hala Kfoury Mahmoud A. Mansour | 2011 | Chemico-Biological Interactions2011，，3： | 2 |
| 3 | Neurobiological consequences of sleep deprivation显示文摘 | Karim Alkadhi Munder Zagaar Alhaider I | | 0，，03： | 1 |
| 4 | Airborne dust size analysis for tropospheric propagation of millimetric waves into dust storms显示文摘 | AHMED A S ALI A ALHAIDER M A | 1987 | IEEE Trans on Geosci and Remote sensing1987，25，5： | 1 |
| 5 | Radio wave propagation into sandstorms system design based on ten-years visibility data in Riyadh, Saudi Arabia显示文摘 | Alhaider M A | 1986 | Int J Infrared TEE Proc1986，133，3： | 1 |
| 6 | Meta- a- nalysis of adverse cardiovascular outcomes associated with antecedent hypertension after myocardial infarc- tion 显示文摘 | Chen G Hemmelgarn B Alhaider S | 2009 | Am J Cardiol2009，104，1： | 1 |
| 7 | The beneficial effects of regular exercise on cognition in REM sleep deprivation: behav- ioral, electrophysiological and molecular evidence显示文摘 | Zagaar M Alhaider I Dao A Levine A Alkarawi A Alzubaidy M | 2012 | Neurobiol Dis2012，45，： | 1 |
| 8 | Spinal 5-HT3 receptor mediared antinocieeption:possible release of GABA显示文摘 | Alhaider AA Lei SZ Wilcox GL | 1991 | J Neurosci1991，11，5： | 1 |
| 9 | The beneficial effects of regular exercise on cognition in REM sleep deprivation: Behavioral, electrophysiological and molecular evidence 显示文摘 | Munder Zagaar lbrahim Alhaider An Dao | 2012 | Neurobiology of Disease2012，45，： | 1 |
| 10 | Neurobiological consequences of sleep deprivation显示文摘 | Alkadhi K Zagaar M Alhaider I | 2013 | Curr Neuropharmacol2013，11，3： | 1 |
| 11 | Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression显示文摘 | Alhaider AA Korashy HM Sayed-Ahmed MM | 2011 | Chemi Biol Interact2011，192，3： | 1 |
| 12 | Metformin attenuates streptozotocin-induced dia- betic nephropathy in rats through modulation of oxi- dative stress genes expression显示文摘 | Alhaider AA Korashy HM Saye&Ahmed MM | 2011 | Chem Bio Inter- act2011，192，3： | 1 |
| 13 | Airborne dust size analysis for tropospheric propagation of millimetric waves into dust storms显示文摘 | ALI A A ALHAIDER M A | 1987 | IEEE Transactions on Geoscience and Remote Sensing1987，25，5： | 1 |
| 14 | Metform- in attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression 显示文摘 | Alhaider A A Korashy H M Sayed-Ahmed M M | 2011 | Chem Biol Interact2011，192，3： | 1 |
| 15 | Metformin attenuates streptozotoein-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression显示文摘 | Alhaider A A Korashy H M Sayed-Ahmed M M | 2011 | Chemico-Biologieal Interactions2011，192，3： | 1 |
| 16 | The Saudi initiative for asthma-2012 update:Guidelines for the diagnosis and management of asthma in adults and children 显示文摘 | AI-Moamary MS Alhaider SA AI-Hajjaj MS | 2012 | Ann Thorac Med2012，7，4： | 1 |
| 17 | Design, synthesis and pharmacological activities of 2-substituted 4-phenylquinolines as potential antidepressant drugs显示文摘 | Alhaider A A Abdelkader M A Notably E J L | 1985 | J Med Chem1985，28，10： | 1 |
| 18 | Neurobiological Consequences of sleep deprivation 显示文摘 | Alkadhi K Zagaar M Alhaider I | 2013 | Curt' Neuropharmacol2013，11，3： | 1 |
| 19 | Differential roles of 5-Hydroxytryptamine1A and 5-Hydroxytryptamine1B receptor subtypes in modulating spinal nociceptive transmission in mice显示文摘 | Alhaider A A Wilcox G L | 1993 | J Pharmacol Exp Ther1993，265，1： | 1 |
| 20 | Impaired neural transmission and synaptic plasticity in superior cervical ganglia from beta-amyloid rat model of Alzheimer's disease显示文摘 | Alzoubi KH Alhaider IA Tran T1 | 2011 | Curt Alzheimer Res2011，8，4： | 1 |
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