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126篇 您的检索式:作者名="Alexandrova"
    题名 作者 年代 出处 被引量
1Assessing Drought Vulnerability of Bulgarian Agriculture through Model Simulations显示文摘Zomitsa Popova Maria Ivanova Luis Santos Pereira Vesselin Alexandrov Katerina Doneva Petra Alexandrova Milena Kercheva 2012Journal of Environmental Science and Engineering(B)2012,1,8:2
2Dynamics of free radical processes in acute ischemic stroke: influence on neurological status and outcome显示文摘Margarita Alexandrova Petyo Bochev Vanya Markova Blagovest Bechev Marina Popova Maya Danovska Virginia Simeonova 2003Journal of Clinical Neuroscience2003,,5:2
3Novel MLH1 frameshift mutation in an extended hereditary nonpolyposis colorectal cancer family显示文摘AIM: To present novel frameshift mutation c.31delC [p.L11X] in the MLH1 gene identified in an extended Bulgarian hereditary non-polyposis colorectal cancer (HNPCC) family and to analyze the molecular and clinical findings within the pedigree concerning the proposal of adequate individual prophylactic strategy for all mutation carriers. METHODS: The pedigree of the family consists of 42 members in four generations. Search for mutations in the MLH1 and hMSH2 genes was performed in the pro-band. After PCR amplification of all exons including flanking intronic regions, amplicons were directly sequenced. RESULTS: The mutation was found in nine from the thirteen pedigree members who signed informed consent to participate in the study. In three adenocarcinomas, microsatellite instability and lack of the MLH1 protein expression were detected. The only one tubulovillous adenoma analyzed was microsatellite stable and the MLH1 protein showed an intact staining. CONCLUSION: The newly described mutation c.31delC is HNPCC causative. Besides the typical clinical features of the syndrome, we found a specific pathologic manifestation such as moderate to high differentiated adenocarcinomas of the colon. One of the mutation carriers developed a benign giant cell soft tissue tumor. The primary tumor localizations were frequently extracolonic and detailed yearly gastrointestinal and gynecological examinations have been proposed to the mutation carriers. We emphasize the importance of including the HNPCC genetic counseling and testing as well in the following surveillance of all patients at risk in the services covered by the health insurance in Bulgaria.Tanya Kirilova Kadiyska Radka Petrova Kaneva Dimitar Georgiev Nedin Alexandrina Borisova Alexandrova Antonina Todorova Gegova Stoyan Ganchev Lalchev Tatyana Christova Vanio Ivanov Mitev Juergen Horst Nadja Bogdanova Ivo Marinov Kremensky 2006World Journal of Gastroenterology2006,12,48:2
4Effect of applied and internal hormones on vitrification and apical necrosis of different plants cultured in vitro 显示文摘KATAEVA N V ALEXANDROVA I G BUTENKO R G 1991Plant Cell Tissue and Organ Culture1991,27,2:1
5Effects of proteasome inhibitor,MG132,on proteasome activity and oxidative status of rat liver显示文摘Alexandrova A Petrov L Georgieva A 2008Cell Biochem Funct2008,26,3:1
6Paraquat induced lipid peroxidation and injury in Ehrlich ascites tumor cells显示文摘Kanskashev P Petrov L Alexandrova A 2000Neoplusma2000,47,2:1
7Sulfur dioxide absorption and desorption by water drops 显示文摘Saboni A Alexandrova S 2001Chem Eng J2001,84,3:1
8Experimental strategies in gene therapy of cancer 显示文摘Alexandrova R 2009J BUON2009,14,1:1
9Xenopus axin-related protein:a link between its centrosomal localization and function in the Wnt/β-catenin pathway显示文摘Alexandrova EM Sokol SY 0,,01:1
10Effects of proteasome inhibitor, MGI32, on proteasome activity and oxidative status of rat liver 显示文摘Alexandrova A Petrov L Georgieva A 2008Cell Biochem Funct2008,26,3:1
11Post-stroke cognitive impairment-phenomenology and prognostic fac- tors 显示文摘Danovska M Stamenov B Alexandrova M 2012J IMAB2012,18,3:1
12Peroxisome proliferator - activated receptors of trophoblast ceils in miscar- riage 显示文摘Alexandrova NV Dubova EA Baev OR 2012Bull Exp Biol Med2012,152,6:1
13Entrepreneurship in a Transition Economy:the Impact of Environment on Entrepreneurial Orientation显示文摘ALEXANDROVA M 2004Problems and Perspectives in Management2004,,2:1
14Elastic-plastic stress distribution in a rotating annular disk 显示文摘ALEXANDROVA N ALEXANDROV S 2004Mechanics Based Design of Structures and Machines2004,32,1:1
15Oxidation of sulfur components in diesel fuel using Fe- TAML catalysts and hydrogen peroxide显示文摘Mondal S Hangun-Balkir Y Alexandrova L 2006Catalysis Today2006,116,:1
16Enzyme induction in cryopreserved human hepatocyte cultures显示文摘Kafert-Kasting S Alexandrova K Barthold M 2006Toxicology2006,220,23:1
17Effect of applied and internal hormones on vitrification and apical necrosis of different plants cultured in vitro显示文摘KATAEVA N V ALEXANDROVA I G BUTENKO R G 1991Plant Cell Tissue and Organ Culture1991,27,2:1
18SHG and AFM study of PECVD a-Si∶H films显示文摘Alexandrova S Danesh P Maslyanitsyn I A 200269(1):391-3942002,69,1:1
19Fluorescent and electron-microscopy immunoassays employing polyclonal and monoclonal antibodies for detection of goose parvovirus infection 显示文摘Alexandrov M Alexandrova R 1999Journal of Virological Methods1999,79,1:1
20Paraquat-induced lipid peroxidation and injury in Ehrlieh ascites tumor cells 显示文摘Karakashev P Petrov L Alexandrova A 2000Neoplasma2000,47,2:1
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