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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Systematic review of emergent laparoscopic colorectal surgery for benign and malignant disease显示文摘Laparoscopic surgery has become well established in the management of both and malignant colorectal disease.The last decade has seen increasing numbers of surgeons trained to a high standard in minimallyinvasive surgery.However there has not been the same enthusiasm for the use of laparoscopy in emergency colorectal surgery.There is a perception that emergent surgery is technically more difficult and may lead to worse outcomes.The present review aims to provide a comprehensive and critical appraisal of the available literature on the use of laparoscopic colorectal surgery(LCS)in the emergency setting.The literature is broadly divided by the underlying pathology;that is,inflammatory bowel disease,diverticulitis and malignant obstruction.There were no randomized trials and the majority of the studies were case-matched series or comparative studies.The overall trend was that LCS is associated with shorter hospital stay,par or fewer complications but an increased operating time.Emergency LCS can be safely undertaken for both benign and malignant disease providing there is appropriate patient selection,the surgeon is adequately experienced and there are sufficient resources to allow for a potentially more complex operation. | Manish Chand Muhammed RS Siddiqui Ashish Gupta Shahnawaz Rasheed Paris Tekkis Amjad Parvaiz Alex H Mirnezami Tahseen Qureshi | 2014 | World Journal of Gastroenterology2014，20，45： | 7 |
| 3 | Computer-based Creativity Enhanced Conceptual Design Model for Non-routine Design of Mechanical Systems显示文摘Computer-based conceptual design for routine design has made great strides, yet non-routine design has not been given due attention, and it is still poorly automated. Considering that the function-behavior-structure(FBS) model is widely used for modeling the conceptual design process, a computer-based creativity enhanced conceptual design model(CECD) for non-routine design of mechanical systems is presented. In the model, the leaf functions in the FBS model are decomposed into and represented with fine-grain basic operation actions(BOA), and the corresponding BOA set in the function domain is then constructed. Choosing building blocks from the database, and expressing their multiple functions with BOAs, the BOA set in the structure domain is formed. Through rule-based dynamic partition of the BOA set in the function domain, many variants of regenerated functional schemes are generated. For enhancing the capability to introduce new design variables into the conceptual design process, and dig out more innovative physical structure schemes, the indirect function-structure matching strategy based on reconstructing the combined structure schemes is adopted. By adjusting the tightness of the partition rules and the granularity of the divided BOA subsets, and making full use of the main function and secondary functions of each basic structure in the process of reconstructing of the physical structures, new design variables and variants are introduced into the physical structure scheme reconstructing process, and a great number of simpler physical structure schemes to accomplish the overall function organically are figured out. The creativity enhanced conceptual design model presented has a dominant capability in introducing new deign variables in function domain and digging out simpler physical structures to accomplish the overall function, therefore it can be utilized to solve non-routine conceptual design problem. | LI Yutong WANG Yuxin DUFFY Alex H B | 2014 | Chinese Journal of Mechanical Engineering2014，27，6： | 5 |
| 4 | Chronic overexpression of PNPLA3^sup I148M^ in mouse liver causes hepatic steatosis显示文摘 | Li John Zhong Huang Yongcheng Karaman Ruchan Ivanova Pavlina T Brown H Alex Roddy Thomas Castro-Perez Jose Cohen Jonathan C Hobbs Helen H | 2012 | EN2012，，11： | 3 |
| 5 | Experimental Validation of a New Ultrasound Method for the Simultaneous Assessment of Radial and Longitudinal Myocardial Deformation Independent of Insonation Angle显示文摘 | Stian Langeland Jan D’hooge Patrick F. Wouters H Alex Leather Piet Claus Bart Bijnens George R. Sutherland | 2005 | Circulation2005，，14： | 2 |
| 6 | A Revised Weighted Sum Decision Model for Robot Selection显示文摘 | Goh C H Alex T Y C Cheng Chun-Hung | 1996 | Computers and Industrial Engineering1996，30，2： | 1 |
| 7 | Thermal performance of a residential desuperheater/water heater system显示文摘 | Alex H W Lee Jerold W Jones | 1996 | Energy Conversion and Management1996，37，4： | 1 |
| 8 | The future renewable electric energy delivery and management system: the energy internet 显示文摘 | Alex H Mariesa L C Gerald T H | 2011 | Proceedings of the IEEE2011，99，1： | 1 |
| 9 | X-ray diffractometric study of micro- crystallite size of naturally colored eottons显示文摘 | Chen H L Alex Y | 2000 | Journal of Applied Polymer Science2000，76，9： | 1 |
| 10 | SWOT analysis : Strengths, weaknes- ses, opportunities and threats of the israeli smallpox revaccination program显示文摘 | Michael H Ran DB Alex L | 2003 | Decision Support Systems2003，5，9： | 1 |
| 11 | Transmission congestion management in competitive electricity power market显示文摘 | Harry S Shangyou H Alex Papalexopoulos | 1998 | IEEE Trans on PWRS1998，13，2： | 1 |
| 12 | Nanopomus Au: A high yield strength material显示文摘 | Juergen B Andrea M H Alex V H | 2005 | J Appl Phys2005，97，02： | 1 |
| 13 | Ⅰ-Ⅴ characteristics and differential conductance fluctuations of Au nanowires显示文摘 | Mehrez H Alex Wlasenko Brian Larade | | Phys Rev B0，65，19： | 1 |
| 14 | Early cessation of triptorelin in in vitro fertilization:a double-blind,randomized study 显示文摘 | Arnold H M Henny J M Alex P E | 2005 | Fertil Steril2005，83，4： | 1 |
| 15 | Disruption of functional connectivity in clinically normal older adults harboring amyloid burden显示文摘 | Trey H Koene RA van Alex B | 2009 | Neurosci2009，29，40： | 1 |
| 16 | Miniature LTCC filters for digital receivers显示文摘 | Alex B Wes F Mike H | 1997 | IEEE MMT-S Digest1997，2，67： | 1 |
| 17 | Parameter estimation of a real single tone from short data records 显示文摘 | FUNGA H W ALEX C KOTB K H l | 2004 | Signal Processing2004，84，： | 1 |
| 18 | GM-CSF deficiency reduces macrophage PPARγ expression and aggravates atherosclerosis in apoE-deficient mice显示文摘 | Michael D Ban H T Alex B | 2006 | Ather Thromb Vasc Biol2006，26，： | 1 |
| 19 | Borehole-to-Surface Electromagnetic Survey 显示文摘 | Tseng H W Becker Alex Wilt M J Deszcz-Pann M | 1998 | Geophysics1998，63，5： | 1 |
| 20 | Groundwater-surface water interaction under scenarios of climate change using a high-resolution transient groundwater model显示文摘 | Jacek Scibek Diana M Allen Alex J Cannon Paul H Whitfield | 2006 | Journal of Hydrology2006，，8： | 1 |
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