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| 1 | Transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis and spinal cord injury显示文摘Neglected for years, astrocytes are now recognized to fulfill and support many, if not all, homeostatic functionsof the healthy central nervous system(CNS). During neurodegenerative diseases such as amyotrophic lateral sclerosis(ALS) and spinal cord injury(SCI), astrocytes in the vicinity of degenerating areas undergo both morphological and functional changes that might compromise their intrinsic properties. Evidence from human and animal studies show that deficient astrocyte functions or loss-of-astrocytes largely contribute to increased susceptibility to cell death for neurons, oligodendrocytes and axons during ALS and SCI disease progression. Despite exciting advances in experimental CNS repair, most of current approaches that are translated into clinical trials focus on the replacement or support of spinal neurons through stem cell transplantation, while none focus on the specific replacement of astroglial populations. Knowing the important functions carried out by astrocytes in the CNS, astrocyte replacement-based therapies might be a promising approach to alleviate overall astrocyte dysfunction, deliver neurotrophic support to degenerating spinal tissue and stimulate endogenous CNS repair abilities. Enclosed in this review, we gathered experimental evidence that argue in favor of astrocyte transplantation during ALS and SCI. Based on their intrinsic properties and according to the cell type transplanted, astrocyte precursors or stem cell-derived astrocytes promote axonal growth, support mechanisms and cells involved in myelination, are able to modulate the host immune response, deliver neurotrophic factors and provide protective molecules against oxidative or excitotoxic insults, amongst many possible benefits. Embryonic or adult stem cells can even be genetically engineered in order to deliver missing gene products and therefore maximize the chance of neuroprotection and functional recovery. However, before broad clinical translation, further preclinical data on safety, reliability and therapeutic efficiency should be collected. Although several technical challenges need to be overcome, we discuss the major hurdles that have already been met or solved by targeting the astrocyte populationin experimental ALS and SCI models and we discuss avenues for future directions based on latest molecular findings regarding astrocyte biology. | Charles Nicaise Dinko Mitrecic Aditi Falnikar Angelo C Lepore | 2015 | World Journal of Stem Cells2015，7，2： | 13 |
| 2 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 3 | 剖宫产术后妇女嚼口香糖有助于肠蠕动恢复并缩短住院时间显示文摘背景 剖宫产术是世界范围内普遍使用的一种外科手术方式。术后肠梗阻(POI)是腹部手术后的常见并发症,定义为:外科手术后协调性肠蠕动短暂停止,从而阻止肠内容物和/或摄入物的有效输送。POI延缓术后恢复,延长住院时间,并使医疗费用增加。尽管有证据表明胃肠(GI)术后嚼El香糖有助于减少肠梗阻,但一项相冲突的循证证据限制了其在剖宫产术后的使用。 | Mario Lepore J Edward Fitzgerald 陈华云 | 2015 | 英国医学杂志中文版2015，0，9： | 2 |
| 4 | Clinical and radiographic results with the fixion in tramedullary nail:an inflatable selfLocking system for long bone fractures显示文摘 | Capuano N Lepore L | 2002 | Osteo Trauma Care2002，10，： | 1 |
| 5 | Volume - specific cutoffs are necessary for reproducible application of prostate - specific antigen density of the transition zone in prostate cancer detection显示文摘 | Taneja SS Tran K Lepor H | 2001 | Urology2001，58，2： | 1 |
| 6 | Reduction of post-thoracotomy pain by cryotherapy of intercostal nerves显示文摘 | Roberts D Pizzarelli G Lepore V | 1988 | Scand J Thorac Cardiovasc Surg1988，22，2： | 1 |
| 7 | Rapid,high-level production of hepatitis B core antigen in plant leaf and its immunogenicity in mice显示文摘 | Huang Z Santi L Lepore K | 2006 | Vaccine2006，24，14： | 1 |
| 8 | The alpha-adrenoceptor subtype mediating the tension of human prostatic smooth muscle显示文摘 | Lepor H Tang R Shapiro E | 1993 | Prostate1993，22，4： | 1 |
| 9 | Alpha tdockers for the treatment of benign prostatie hyperldasia显示文摘 | LEPOR H | 2007 | Rev Urol2007，9，： | 1 |
| 10 | Lipids and renal disease显示文摘 | Trevisan R Dodesini AR Lepore G | 2006 | J Am Soc Nephrol2006，17，42： | 1 |
| 11 | Silodosin for the treatment of benign prostatichyperplasia: pharmacology and cardiovascular tolerability显示文摘 | Lepor H Hill L A | 2010 | Pharmacotherapy2010，30，12： | 1 |
| 12 | Impact of polyacrylamide delivery method with lime or gypsum for soil and nutrient stabilization 显示文摘 | Lepore B J Thompson A M Petersen A | 2009 | Soil and Water Conservation2009，64，3： | 1 |
| 13 | Intramedullary nailing of the femur with an inflatable self-locking:comparison with locked nailing显示文摘 | Lopore L Lepore S Maffulli N | 2003 | J Orthop Sci2003，6，： | 1 |
| 14 | Antiproliferative oleanane saponins from Polysciasguilfoylei 显示文摘 | Cioffi G Vassatlo A Lepore L | 2008 | Nat Prod Commun2008，3，10： | 1 |
| 15 | Idiopathic retroperitoneal fibrosis显示文摘 | Lepor H Walsh PC | 1979 | J Urol1979，122，： | 1 |
| 16 | Bilateral internuclear ophthalmoplegia after intrathecal chemotherapy and cranial irradiation 显示文摘 | Lepore FE Nissenblatt MJ | 1981 | Am J Ophthalmol1981，92，6： | 1 |
| 17 | Tamsulosin reduces the incidence of acute u- rinary retention following early removal of the urinary catheter after radi- cal retropubic prostatectomy 显示文摘 | Patel R Fiske J Lepor H | 2003 | Urology2003，62，2： | 1 |
| 18 | Clonical and radiographic results with the fixion intramedullary nail: an inflatable self-locking system for long bone fractures显示文摘 | Lepore S Capuano N Lepore L | 2002 | Osteo Trauma Care2002，，： | 1 |
| 19 | Medical therapy for benign prostatic hyperplasia显示文摘 | Lepor H Tang R Meretyk S | 1993 | J Urol1993，149，： | 1 |
| 20 | Lipids and renal disease 显示文摘 | Trevisan R Dodesini AR Lepore G | 2006 | J Am Soc Nephrol2006，17，2： | 1 |
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