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| 1 | Imatinib-induced fatal acute liver failure显示文摘Imatinib mesylate is a drug that has been approved for treatment of chronic myeloid leukemia (CML) in blast crisis, accelerated or chronic phase, and also for advanced gastrointestinal stromal tumors. Severe hepatic toxicity and three deaths from hepatic failure have been reported. We report the case of a 51-year-old woman who was admitted to our institution with severe acute hepatitis. She was diagnosed with CML and began treatment with imatinib mesylate at a dose of 400 mg/d. Five months after beginning treatment, she developed severe hepatitis associated with coagulopathy, and was admitted to our institution. She had been consuming acetaminophen 500-1000 mg/d after the onset of symptoms. She had a progressive increase in bilirubin level and a marked decrease of clotting factor Ⅴ. Five days after admission, grade Ⅱ encephalopathy developed and she was referred for liver transplantation. Her clinical condition progressively deteriorated, and 48 h after being referred for transplantation she suffered a cardiac arrest and died. This report adds concern about the possibility of imatinib-mesylate-induced hepatotoxicity and liver failure, particularly in the case of concomitant use with acetaminophen. Liver function tests should be carefully monitored during treatment and, with the appearance of any elevation of liver function tests, treatment should be discontinued. | Ezequiel Ridruejo Roberto Cacchione Alejandra G Villamil Sebastián Marciano Adrián C Gadano Oscar G Mandó | 2007 | World Journal of Gastroenterology2007，13，48： | 5 |
| 2 | YKL40 expression in CD14^+ liver cells in acute and chronic injury显示文摘AIM:To demonstrate that CD14 + cells are an important source of the growth factor YKL40 in acute and chronic liver damage.METHODS:Rats were inoculated with one dose of CCl4 to induce acute damage.Liver biopsies were obtained at 0,6,12,24,48 and 72 h.For chronic damage,CCl4 was administered three days per week for 6 or 8 wk.Tissue samples were collected,and cellular populations were isolated by liver digestion and purified by cell sorting.YKL40 mRNA and protein expression were evaluated by realtime polymerase chain reaction and western blot.RESULTS:Acute liver damage induced a rapid increase of YKL40 mRNA beginning at 12 h.Expression peaked at 24 h,with a 26fold increase over basal levels.By 72 h however,YKL40 expression levels had nearly returned to control levels.On the other hand,chronic damage induced a sustained increase in YKL40 expression,with 7and 9fold higher levels at 6 and 8 wk,respectively.The pattern of YKL40 expression in different subpopulations showed that CD14+cells,which include Kupffer cells,are a source of YKL40 after acute damage at 72 h[0.09 relative expression units(REU)]as well as after chronic injury at 6 wk(0.11 REU).Hepatocytes,in turn,accounted for 0.06 and 0.01 REU after 72 h(acute)or 6 wk(chronic),respectively.The rest of the CD14cells(including T lymphocytes,B lymphocytes,natural killer and natural killer T cells) yielded 0.07 and 0.15 REU at 72 h and 6 wk,respectively.YKL40 protein expression in liver was detected at 72 h as well as 6 and 8 wk,with the highest expression relative to controls(11fold;P≤0.05)seen at 6 wk.Macrophages were stimulated by lipopolysaccharide.We demonstrate that under these conditions,these cells showed maximum expression of YKL40 at 12 h,with P<0.05 compared with controls.CONCLUSION:Hepatic CD14 + cells are an YKL40 mRNA and protein source in acute and chronic liver injury,with expression patterns similar to growth factors implicated in inflammationfibrogenesis. | Oscar Pizano-Martínez Irinea Yaez-Sánchez Pilar Alatorre-Carranza Alejandra Miranda-Díaz Pablo C Ortiz-Lazareno Trinidad García-Iglesias Adrian Daneri-Navarro Mónica Vázquez-Del Mercado Mary Fafutis-Morris Vidal Delgado-Rizo | 2011 | World Journal of Gastroenterology2011，17，33： | 3 |
| 3 | Acetylcholinesterase accderates assembly of amyloid-β-peptides into Azheimer' s fibrils : Possible role of the peribheral site of the enzyme显示文摘 | Nibaldo C Inestrosa Alejandra A | 1996 | Neuron1996，16，： | 1 |
| 4 | 1H and DOSY NMR spectroscopy analysis of Ligusticum porteri rhizome extracts 显示文摘 | Alejandra L Maria Isabel C Guillermo D | 2011 | Magn Reson Chem2011，49，8： | 1 |
| 5 | CITRX thiore- doxin interacts with the tomato Cf- 9 resistance protein and negatively regulates defence 显示文摘 | Susana R Alejandra R C Matthew S | 2004 | The EMBO Journal2004，23，10： | 1 |
| 6 | Probiotics: An alternative strategy for combating salmonellosis Immune mechanisms involved 显示文摘 | Natalia A C Alejandra M L Galdeano C M | 2012 | Food Res Int2012，45，2： | 1 |
| 7 | CITRX thioredoxin interacts with the tomato Cf-9 resistance protein and negatively regulates defence 显示文摘 | Susana R Alejandra R C Matthew S | 2004 | The EMBO Journal2004，23，10： | 1 |
| 8 | Fear avoidance beliefs do not influence disability and quality of life in Spanish elderly subjects with low back pain 显示文摘 | Francisco K Victor A Alejandra C | 2007 | Spine2007，32，： | 1 |
| 9 | Recurrent primary cerebral hemorrhage:frequency,mechanisms,and prognosis显示文摘 | Alejandra G Duurte Carlos C Jose Luis Ru | 1998 | Stroke1998，29，3： | 1 |
| 10 | Laboratory goals and considerations for multiple mierofossil extraction in archaeology显示文摘 | JAMES C ALEJANDRA K M STEVEN A | 2003 | Journal of Archaeological Science2003，30，： | 1 |
| 11 | Comparison of shikimic acid determination by capillary zone electrophoresiswith direct and indirect detection with liquid chromatography for varietal differentiation of red wines显示文摘 | Claudia M Antonieta H Alejandra C | | 0，，： | 1 |
| 12 | The opening of maitotoxin-sensitive calcium channels induces the acrosome reaction in human spermatozoa: differences from the zona pellucida显示文摘acrosome 反应(AR ) ,为精子的一个绝对要求和卵熔化,通过电压依赖者 Ca2+ 隧道和操作店的隧道要求 Ca2+ 的流入进精子。Maitotoxin (MTx ) ,一个动员 Ca2+ 代理人,被显示了是老鼠精子 AR 的有势力 inducer 与类似于带 pellucida (ZP ) 的药理学,可能为两 inducers 建议一条普通小径。使用的 recombinant 人 ZP3 (rhZP3 ) ,老鼠 ZP 和二 MTx 隧道 blockers (U73122 和 U73343 ) ,我们在人和老鼠精子调查了并且比较导致 MTx 、导致 ZP 的艺术。此处,我们报导 MTx 导致了 AR 并且提高了细胞内部的 Ca2+([Ca2+] 我) 在人的精子,哪个被 U73122 和 U73343 堵住。这二混合物也在老鼠精子禁止了导致 MTx 的 AR。在有我们的以前的建议的争论, AR 由 rhZP3 被触发或老鼠 ZP 没被 U73343 堵住,显示在人和老鼠精子,由生理的 ligands 或由 MTx 的 AR 正式就职通过不同小径发生了。U73122,然而并非 U73343 (不活跃的类似物) ,能堵住 phospholipase C (PLC ) 。另一个 PLC 禁止者, edelfosine,也堵住了导致 rhZP3 、导致 ZP 的艺术。这些调查结果在人和老鼠带证实了一条 PLC 依赖的发信号小径的参予导致蛋白质的 AR。尤其是, edelfosine 也禁止了导致 MTx 的老鼠精子 AR 然而并非人的,建议导致毒素的 AR 在老鼠是 PLC 依赖的并且在人 PLC 独立。 | lulio C Chaivez Gerardo A de Blas Josd L de la Vega-Beltran Takuya Nishigaki Mayel Chirinos Maria Elena Gonzaez-Gonzalez Fernando Larrea Alejandra Soiis Alberto Darszon Claudia L Trevino | 2011 | Asian Journal of Andrology2011，13，1： | 1 |
| 13 | Survival of heat stress with and without heat hardening in Drosophila melanogaster; interactions with larval density 显示文摘 | LETICIA N A PABLO S ALEJANDRA C S | 2012 | The Journal of Experimental Biology2012，215，13： | 1 |
| 14 | Spatial patterns of photosynthesis in thin-and thick-leaved epiphytic orchids:unravelling C3-CAM plasticity in an organ-compartmented way显示文摘 | IVhria A R Alejandra M Aline B C | 2013 | Annals of Botany2013，112，： | 1 |
| 15 | Overweightand obesity:prevalence and their association with somesocial characteristics in a random sample population-basedstudy in C rdoba city,Argentina显示文摘 | Laura RA Alberto RO Alejandra C | 2009 | Obes Res ClinPract2009，3，2： | 1 |
| 16 | Burden of care in families of patients with schi- zophrenia 显示文摘 | Alejandra C Jose GM | 2006 | Quality of Life Research2006，，15： | 1 |
| 17 | Metals in Alcoholic Beverages: A Review of Sources, Effects, Concentrations, Removal, Speciation, and Analysis 显示文摘 | JORGE G I ALEJANDRA C A MAXIMILIANO B S | 2008 | Journal of Food Composition and?Analysis2008，21，8： | 1 |
| 18 | Pharamacodynamic assessment of amoxicillin/sulbactam against Acinetobacter baumannii:searching the optimal dose and infusion time through a human ex-vivo model显示文摘 | Bantar C Fernandez Canigia L Alejandra Berger M | 2009 | Braz J Infect Dis2009，13，5： | 1 |
| 19 | Burdon of care in families of patients with schizophrenia显示文摘 | Alejandra C Jose GM | 2006 | Quality of Life Research2006，15，： | 1 |
| 20 | Antioxidant effects of water-and lipid-soluble nitroxide radicals in liposomes显示文摘 | Alejandra N C Lidia L P Graciela B | 2004 | Free Radical Biology and Medicine2004，37，12： | 1 |
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