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| 1 | Determination of drug,excipients and coating distribution in pharmaceutical tablets using NIR-CI显示文摘The growing interest of the pharmaceutical industry in Near Infrared-Chemical Imaging (NIR-CI) is a result of its high usefulness for quality control analyses of drugs throughout their production process (particularly of its non-destructive nature and expeditious data acquisition).In this work,the concentration and distribution of the major and minor components of pharmaceutical tablets are determined and the spatial distribution from the internal and external sides has been obtained.In addition,the same NIR-CI allowed the coating thickness and its surface distribution to be quantified.Images were processed to extract the target data and calibration models constructed using the Partial Least Squares (PLS) algorithms.The concentrations of Active Pharmaceutical Ingredient (API) and excipients obtained for uncoated cores were essentially identical to the nominal values of the pharmaceutical formulation.But the predictive ability of the calibration models applied to the coated tablets decreased as the coating thickness increased. | Anna Palou Jordi Cruz Marcelo Blanco Jaume Tomàs Joaquín de los Ríos Manel Alcalà | 2012 | Journal of Pharmaceutical Analysis2012，2，2： | 4 |
| 2 | Validation of the Epworth sleepiness scale in Mexican po-pulation显示文摘 | Sandoval-Rincón M Alcalá-Lozano R Herrera-Jiménez I | 2013 | Gac Med Mex2013，149，4： | 1 |
| 3 | Intranasal delivery of neurotrophic factors BDNF,CNTF,EPO,and NT-4 to the CNS显示文摘 | Alcalá-Barraza S R Lee M S Hanson L R McDonald A A Frey W H 2nd McLoon L K | | 0，，： | 1 |
| 4 | An artificial neural network approach to Escherichia coli O157:H7 growth estimation显示文摘 | García-Gimeno R M Hervás-Martínez C Barco Alcalá E | 2003 | Journal of Food Science2003，68，2： | 1 |
| 5 | Re- action kinetics measurements and analysis of re- action pathways for conversions of acetic acid, ethanol, and ethyl acetate over silica-supported Pt 显示文摘 | Gursahani KI Alcale R Cortright RD | 2001 | Appl Catal A2001，222，： | 1 |
| 6 | Guest editorial genetic fuzzy systems: what ' s next? an introduction to the special section 显示文摘 | CORDN O ALCAL R ALCAL-FDEZ J | 2007 | IEEE Transactions on Fuzzy Systems2007，15，4： | 1 |
| 7 | Learning the membership function contexts for mining fuzzy association rules by using genetic algorithms显示文摘 | Alcal'a-Fdez J Alcal'a R Gacto M J | 2009 | IEEE Trans on Fuzzy Sets and Systems2009，160，7： | 1 |
| 8 | Cross-relaxation for Tm3 + ions in indium-based glasses 显示文摘 | Martin I R Rodriguez V D Alcal A R | 1993 | Journal of Non-Crystalline Solids1993，161，2： | 1 |
| 9 | In Situ Photopolymerization of Biomaterials by Thiol yne Click Chemistry 显示文摘 | Lomba M Oriol L Alcal 6 R | 2011 | Macromolecular bioscience2011，11，11： | 1 |
| 10 | Dynamics of lattice disorder in perovskite materials, polarization nanoclusters and ferroelectric domain wall structures显示文摘The nexus between classic ferroelectricity and the structure of perovskite materials hinges on the concept of lattice disorder.Although the ordered perovskites display short-range displacements of the central cations around their equilibrium points,the lattice disorder dynamically unfolds to generate a myriad of distorted rhombohedral lattices characterized by the hopping of the central cations across<111>directions.It is discovered that the lattice disorder correlates with the emergence of minimum configuration energy<100>pathways for the central cations,resulting in spatially modulated ultrafast polarization nanocluster arrangements that are stabilized by the electric charge defects in the material.Through high-resolution phonon dispersion analyses encompassing molecular dynamics(MD)and density functional theory(DFT)simulations,we provide unequivocal evidence linking the hopping of central cations to the development of diffuse soft phonon modes observed throughout the phase transitions of the perovskite.Through massive MD simulations,we unveil the impact of lattice disorder on the structures of domain walls at finite-temperature vis-à-vis collective activation and deactivation of<100>pathways.Furthermore,our simulations demonstrate the development of hierarchical morphotropic phase boundary(MPB)nanostructures under the combined influence of externally applied pressure and stress relaxation,characterized by sudden emergence of zig-zagged monoclinic arrangements that involve dual<111>shifts of the central cations.These findings have implications for tailoring MPBs in thin-film structures and for the light-induced mobilization of DWs.Avenues are finally uncovered to the exploration of lattice disorder through gradual shear strain application. | Jan Očenášek Ján Minár Jorge Alcalá | 2023 | npj Computational Materials2023，，1： | 0 |
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