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| 1 | Determination of drug,excipients and coating distribution in pharmaceutical tablets using NIR-CI显示文摘The growing interest of the pharmaceutical industry in Near Infrared-Chemical Imaging (NIR-CI) is a result of its high usefulness for quality control analyses of drugs throughout their production process (particularly of its non-destructive nature and expeditious data acquisition).In this work,the concentration and distribution of the major and minor components of pharmaceutical tablets are determined and the spatial distribution from the internal and external sides has been obtained.In addition,the same NIR-CI allowed the coating thickness and its surface distribution to be quantified.Images were processed to extract the target data and calibration models constructed using the Partial Least Squares (PLS) algorithms.The concentrations of Active Pharmaceutical Ingredient (API) and excipients obtained for uncoated cores were essentially identical to the nominal values of the pharmaceutical formulation.But the predictive ability of the calibration models applied to the coated tablets decreased as the coating thickness increased. | Anna Palou Jordi Cruz Marcelo Blanco Jaume Tomàs Joaquín de los Ríos Manel Alcalà | 2012 | Journal of Pharmaceutical Analysis2012，2，2： | 4 |
| 2 | Prognostic value of the sTREM-1 plasma values in patients with sepsis:acohort study显示文摘 | Latour-Pérez J Alcalá-López A García-García MA | 2010 | Med Intensiva2010，34，4： | 1 |
| 3 | Se-roepidemiology of porcine enteric sapovirus in pig farms inVenezuela显示文摘 | ALCALA C RODRGUEZ-DAZ J DE ROLO M | 2010 | Vet Immunol Immunopathol2010，137，34： | 1 |
| 4 | Validation of the Epworth sleepiness scale in Mexican po-pulation显示文摘 | Sandoval-Rincón M Alcalá-Lozano R Herrera-Jiménez I | 2013 | Gac Med Mex2013，149，4： | 1 |
| 5 | Intranasal delivery of neurotrophic factors BDNF,CNTF,EPO,and NT-4 to the CNS显示文摘 | Alcalá-Barraza S R Lee M S Hanson L R McDonald A A Frey W H 2nd McLoon L K | | 0，，： | 1 |
| 6 | An artificial neural network approach to Escherichia coli O157:H7 growth estimation显示文摘 | García-Gimeno R M Hervás-Martínez C Barco Alcalá E | 2003 | Journal of Food Science2003，68，2： | 1 |
| 7 | Re- action kinetics measurements and analysis of re- action pathways for conversions of acetic acid, ethanol, and ethyl acetate over silica-supported Pt 显示文摘 | Gursahani KI Alcale R Cortright RD | 2001 | Appl Catal A2001，222，： | 1 |
| 8 | On the relation between regular variation and the asymptotic elasticity of substitution显示文摘 | Luis A. Alcalá | 2014 | Economics Letters2014，，： | 1 |
| 9 | Comparison of Sensititre YeastOne? With the NCCLS M38-A microdilution method to determine the activity of amphotericin B,voriconazole,and itraconazole against clinical isolates of Aspergillus fumigatus显示文摘 | Jesús Guinea Teresa Peláez Luis Alcalá | 2006 | Diagnostic Microbiology and Infectious Disease2006，56，1： | 1 |
| 10 | A genetic rule weighting and selection process for fuzzy control of heating,ventilating and air conditioning systems显示文摘 | Alcalá Rafael Casillas Jorge Cordón Oscar | 2005 | Engineering Applications of Artificial Intelligence2005，18，3： | 1 |
| 11 | Community infectionscaused by extended-spectrum beta-lactamase-producing Escherichia coli显示文摘 | Rodríguez-Ba o J AlcaláJC Cisneros JM | 2008 | Arch Intern Med2008，168，： | 1 |
| 12 | Guest editorial genetic fuzzy systems: what ' s next? an introduction to the special section 显示文摘 | CORDN O ALCAL R ALCAL-FDEZ J | 2007 | IEEE Transactions on Fuzzy Systems2007，15，4： | 1 |
| 13 | Bloodstream infections:evolution and trends in the microbiology workload,incidence,and etiology,1985-2006显示文摘 | Rodríguez-Créixems M Alcalá L Mu(n)oz P | | 0，，： | 1 |
| 14 | Community infections caused by extended-spectrum beta-lactamase-producing Escherichia coli显示文摘 | Rodríguez-Bano J Alcalá JC Cisneros JM | 2008 | Arch Intern Med2008，168，17： | 1 |
| 15 | The role of friction on sharp indentation显示文摘 | Mata M AlcaláJ | 2004 | J Mech Phys Solids2004，2，： | 1 |
| 16 | Bloodstream infections:evolution and trends in the microbiology workload,incidence,and etiology,1985-2006显示文摘 | Rodríguez-Créixems M Alcalá L Mu(n)oz P | | 0，，： | 1 |
| 17 | Learning the membership function contexts for mining fuzzy association rules by using genetic algorithms显示文摘 | Alcal'a-Fdez J Alcal'a R Gacto M J | 2009 | IEEE Trans on Fuzzy Sets and Systems2009，160，7： | 1 |
| 18 | The Use of a Hydrological-Economic Model to Assess Sustainability in Groundwater-Dependent Agriculture in Drylands显示文摘 | VALDERRAMA J M IBEZ J ALCALF J | 2011 | Journal of Hydrology2011，402，1： | 1 |
| 19 | Continuous measurements of load-penetration curves with spherical microindenters and the estimation of mechanical properties显示文摘 | ALCALJ GIANNAKOPOULOS A E SURESH S | 1998 | Journal of Materials Research1998，13，5： | 1 |
| 20 | Influence of the experimental conditions and the grinding of the starting materials on the structure of silicon nitride synthesised by carbothermal reduction显示文摘 | M D ALCAL'A J M CRIADO C REAL | 2001 | Solid State Ionics2001，，： | 1 |
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