|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Gut microbiota mediated molecular events and therapy in liver diseases显示文摘Gut microbiota is a community of microorganisms that reside in the gastrointestinaltract. An increasing number of studies has demonstrated that the gutliveraxis plays a critical role in liver homeostasis. Dysbiosis of gut microbiota cancause liver diseases, including nonalcoholic fatty liver disease and alcoholic liverdisease. Preclinical and clinical investigations have substantiated that themetabolites and other molecules derived from gut microbiota and diet interactionfunction as mediators to cause liver fibrosis, cirrhosis, and final cancer. This effecthas been demonstrated to be associated with dysregulation of intrahepaticimmunity and liver metabolism. Targeting these findings have led to thedevelopment of novel preventive and therapeutic strategies. Here, we review thecellular and molecular mechanisms underlying gut microbiota-mediated impacton liver disease. We also summarize the advancement of gut microbiota-basedtherapeutic strategies in the control of liver diseases. | Xiaoqiang Qi Ming Yang Joseph Stenberg Rahul Dey Leslie Fogwe Muhammad Shawkat Alam Eric TKimchi Kevin F Staveley-O'Carroll Guangfu Li | 2020 | World Journal of Gastroenterology2020，26，48： | 5 |
| 2 | Consecutive fecal calprotectin measurements for predicting relapse in pediatric Crohn's disease patients显示文摘BACKGROUND Asymptomatic children with Crohn's disease(CD) require ongoing monitoring to ensure early recognition of a disease exacerbation.AIM In a cohort of pediatric CD patients, we aimed to assess the utility of serial fecal calprotectin measurements to detect intestinal inflammatory activity and predict disease relapse.METHODS In this prospective longitudinal cohort study, children with CD on infliximab therapy in clinical remission were included. Fecal calprotectin levels were assessed at baseline and at subsequent 2-5 visits. Clinical and biochemical disease activity were assessed using the Pediatric Crohn's Disease Activity Index, Creactive protein and erythrocyte sedimentation rate at baseline and at visits over the following 18 mo.RESULTS 53 children were included and eighteen patients(34%) had a clinical disease relapse during the study. Baseline fecal calprotectin levels were higher in patients that developed symptomatic relapse [median(interquartile range), relapse 723μg/g(283-1758) vs 244 μg/g(61-627), P = 0.02]. Fecal calprotectin levels > 250μg/g demonstrated good predictive accuracy of a clinical flare within 3 mo(area under the receiver operator curve was 0.86, 95% confidence limits 0.781 to 0.937).CONCLUSION Routine fecal calprotectin testing in children with CD in clinical remission is useful to predict relapse. Levels > 250 μg/g are a good predictor of relapse in the following 3 mo. This information is important to guide monitoring standards used in this population. | Alice Jane Foster Matthew Smyth Alam Lakhani Benjamin Jung Rollin F Brant Kevan Jacobson | 2019 | World Journal of Gastroenterology2019，25，10： | 3 |
| 3 | Studies of γ-ray induced polymerization of aqueous acrylamide 显示文摘 | ALAM M AKHTAR F MINA M | 2003 | Polymer plastics Tech- nology and Engineering2003，42，2： | 1 |
| 4 | Cogging torque optimization in surface-mounted permanent-magnet motors by using design of experiment显示文摘 | ABBASZADEH K REZAEE ALAM F SAIED S A | 2011 | Energy Conversion and Management2011，52，10： | 1 |
| 5 | Slot opening optimization of surface mounted permanent magnet motor for cogging torque reduction显示文摘 | ABBASZADEH K REZAEE ALAM F TESHNEHLAB M | 2012 | Energy Conversion and Management2012，55，： | 1 |
| 6 | A comparison of experimental designs in the development of a neural network simulation metamodel 显示文摘 | ALAM F M MCNAUGHT K R RINGROSE T J | 2004 | Simulation Modelling Practice and Theory2004，12，78： | 1 |
| 7 | Expression and function of a hybrid Bt toxin gene in transgenic rice conferring resistance to insect pests显示文摘 | Tu J Datta K Alam M F | 1998 | Plant Bioteehnol1998，15，： | 1 |
| 8 | Training neural networks using central force optimization and particle swarm optimization: insights and comparisons 显示文摘 | ROBERT C G WANG L F ALAM M | 2012 | Expert Systems with Applications2012，39，1： | 1 |
| 9 | Evaluation of hybrid RANS/LES models for prediction of flow around surface com-batant and Suboff geometries显示文摘 | Bhushan S Alam M F Walters D K | 2013 | Computers & Fluids2013，88，： | 1 |
| 10 | Traffic shaping for MPEG video transmission over the next generation Internet显示文摘 | ALAM M F ATIQUZZAMAN M KARIM M A | 2000 | Computer Communications2000，23，1415： | 1 |
| 11 | Development and evaluation of acid-buffering bioadhesive vaginal tablet for mixed vaginal infections显示文摘 | Alam M A Ahmad F J Khan Z I | 2007 | AAPS Pharm Sci Tech2007，8，4： | 1 |
| 12 | Reports from Yonsei University add new data to research in sensors and actuators 显示文摘 | Zahirul Alam Mohd K F | 2008 | Chemicals & Chemistry2008，，8： | 1 |
| 13 | Automatic target detection in forward-looking infrared imagery via probabilistic neural networks 显示文摘 | Khan J F Alam M S Bhuiyan S | 2009 | Applied Optics2009，48，3： | 1 |
| 14 | Prelimiary results onthe role of embryonic human chorionic gonadotrophin in corpusluteum rescue during early pregnancy and the relationship toabortion and ectopic pregnancy 显示文摘 | Alam V Altieri E Zegers Hochschild F | 1999 | Hum Epord*1999，14，9： | 1 |
| 15 | Primary syphilis remains a cause of oral ulcration显示文摘 | Alam F Argiriadou AS Hodgson TA | 2000 | Br Dent J2000，189，： | 1 |
| 16 | Dual polarization measurements in the hybrid plasmonic biosensors显示文摘 | BAHRAMI F ALAM M Z AITCHISON J S | 2013 | Plasmonics2013，8，： | 1 |
| 17 | Polyglycols as base fluids for environmentally-friendly lubricants 显示文摘 | Van Voorst R Alam F | 2000 | Journal of Synthetic Lubrication2000，16，4： | 1 |
| 18 | The Wilms tumor gene, Wtl ,is required for Sox9 expression and maintenance of tubular archi- tecture in the developing testis显示文摘 | Gao F Maiti S Alam N | 2006 | Proc Natl Acad Sci U S A2006，103，11： | 1 |
| 19 | Constitutive and tissue-specific differential expression of the cryIA(b)gene in transgenic rice plants conferring resistance to rice insect pest显示文摘 | Datta K Vasquez A Tu J M Tonizo L Alam M F Oliva N Abrigo E Cohen M Khush G S and Datta SK | | 0，，： | 1 |
| 20 | Squamous cell carcinoma of colon and rectum显示文摘 | Fahim F Al-Salamah SM Alam MK | 2006 | Saudi Med J2006，27，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员