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| 1 | Comparison of subconjunctivally injected bevacizumab, ranibizumab, and pegaptanib for inhibition of corneal neovascularization in a rat model显示文摘AIM: To compare the efficacies of subconjunctival bevacizumab, ranibizumab, and pegaptanib sodium injections for the inhibition of corneal neovascularization in an experimental rat model. METHODS: Sixteen corneas of 16 rats were chemically cauterized and randomized into four groups: bevacizumab group that treated with 0.05mL/1.25mg bevacizumab, ranibizumab group that treated with 0.05mL/0.5mg ranibizumab, pegaptanib group that treated with 0.05mL/0.15mg pegaptanib sodium, and control group that treated with 0.05mL saline solution. Digital photographs of the corneas were taken and analyzed using an image analysis software program. All corneas were excised and examined histologically on the 15 th day. RESULTS: Each treatment group had significantly less neovascularized corneal areas and fewer blood vessels than the control group (all P <0.05). In addition, bevacizumab group had significantly less neovascu-larized corneal areas and fewer blood vessels than ranibizumab and pegaptanib groups (both P <0.05). However, there was no significant difference between the ranibizumab and pegaptanib groups regarding percentage of neovascularized corneal areas and number of blood vessels (both P >0.05). CONCLUSION: Subconjunctival bevacizumab, ranibiz-umab, and pegaptanib sodium were effective with no corneal epitheliopathy for inhibiting corneal neovascularization after corneal burn in rats .Bevacizumab was more effective than ranibizumab and pegaptanib sodium. | Ebru Eren Akar Veysi ner Cem Küükerdnmez Yonca Aydin Akova | 2013 | International Journal of Ophthalmology(English edition)2013，6，2： | 9 |
| 2 | Does topical bevacizumab prevent postoperative recurrence after pterygium surgery with conjunctival autografting?显示文摘AIM:To assess the effect of topical bevacizumab use on postoperative pterygium recurrence in eyes who underwent pterygium excision with limbal-conjunctival autograft transplantation(LCAT).METHODS:eighty-eight eyes of 88 patients with primary pterygium were included.Pterygia were graded preoperatively from type 1 to type 3(type 1 atrophic,type3 inflamed)according to the inflammatory status.The eyes were preoperatively randomized to receive topical steroid and antibiotic treatment(group 1,46 eyes)and additional topical bevacizumab(5 mg/mL;group 2,42eyes)in the postoperative period.All eyes underwent pterygium excision and LCAT.Medications were tapered and discontinued at one month.Postoperative complications and recurrence rates were recorded.RESULTS:The mean follow-up duration was 29.3±4.2mo(24-52mo)and 28.5±3.4(24-48mo)in group 1 and2,respectively(P>0.05).There were no statistically significant differences regarding the age or gender between groups(P>0.05).Also,the difference between groups with respect to pterygium type was not significant.During the follow-up period,recurrence developed in 2 eyes(4.3%)in group 1,whereas in one eye(2.4%)in group 2.No statistically significant difference between groups was found in recurrence rates(P>0.05).No re-operation for recurrence was necessary during the follow-up period in both groups.CONCLUSION:Topical bevacizumab seems to have no additonal effect on pterygium recurrence after LCAT. | Aylin Karalezli Cem Kucukerdonmez Yonca A. Akova Bengu Ekinci Koktekir | 2014 | International Journal of Ophthalmology(English edition)2014，7，3： | 3 |
| 3 | Acute effects of static stretching on peak and end-range hamstring-to-quadriceps functional ratios显示文摘AIM: To evaluate if static stretching influences peak and end-range functional hamstring-to-quadriceps(H/Q) strength ratios in elite women athletes. METHODS: Eleven healthy female athletes in an elite competitive level participated to the study. All the participants fulfilled the static stretching or non-stretching(control) intervention protocol in a randomized design on different days. Two static unassisted stretching exercises, one in standing and one in sitting position, were used to stretch both the hamstring and quadriceps muscles during these protocols. The total time for the static stretching was 6 ± 1 min. The isokinetic peak torque measurements for the hamstring and quadriceps muscles in eccentric and concentric modes and the calculations for the functional H/Q strength ratios at angular velocities of 60°/s and 180°/s were made before(pre) and after(post) the control or stretching intervention. The strength measurements and functional strength ratio calculations were based during the entire- and end-range of knee extension.RESULTS: The pre-test scores for quadriceps and hamstring peak torque and end range values were not significantly different between the groups(P > 0.05). Subsequently, although the control group did notexhibit significant changes in quadriceps and hamstring muscle strength(P > 0.05), static stretching decreased eccentric and concentric quadriceps muscle strength at both the 60°/s and 180°/s test speeds(P < 0.01). Similarly, static stretching also decreased eccentric and concentric hamstring muscle strength at both the 60°/s and 180°/s test speeds(P < 0.01). On the other hand, when the functional H/Q strength ratios were taken into consideration, the pre-intervention values were not significant different between the groups both during the entire and end range of knee extension(P > 0.05). Furthermore, the functional H/Q strength ratios exhibited no significant alterations during the entire and end ranges of knee extension both in the static stretching or the control intervention(P > 0.05). CONCLUSION: According to our results, static stretching routine does not influence functional H/Q ratio. Athletes can confidently perform static stretching during their warm-up routines. | Ufuk Sekir Ramiz Arabaci Bedrettin Akova | 2015 | World Journal of Orthopedics2015，6，9： | 2 |
| 4 | Interventional strategies and current clinical experience with carbapenemase- producing Gram- negative bacteria显示文摘 | Akova M Daikos GL Tzouvelekis L | 2012 | Clin Microbiol Infect2012，18，5： | 1 |
| 5 | Concentric versus combined concentric-eccentric isokinetic training:effects on functional capacity and symptoms in patients with osteoarthrosis of the knee显示文摘 | Gür H Cakin N Akova B Okay E Kü(c)üko(g)lu S | | 0，，： | 1 |
| 6 | Comparison of Conjunctival Autograft With Amniotic Membrane Transplantation for Pterygium Surgery: Surgical and Cosmetic Outcome显示文摘 | Cem Kü?ükerd?nmez Yonca A Akova Dilek Dursun Altn?rs | 2007 | Cornea2007，，4： | 1 |
| 7 | Porcelain surface treatment by laser for bracket-porcelain bonding显示文摘 | Akova T Yoldas O Toroglu MS | | 0，，05： | 1 |
| 8 | Comparison of the bond strength of laser- sintered and cast base metal dental alloy to porcelain 显示文摘 | Akova T Ucar Y Tukay A | 2008 | Dent Mater2008，24，10： | 1 |
| 9 | Efficacy of fluconazole in the treatment of upper gastrointestinal candidiasis in neutropenic patients with cancer: factors influencing the outcome 显示文摘 | Akova M Akalin H E Uzun O | 1994 | Clin Infect Dis1994，18，2： | 1 |
| 10 | Microbial keratitis following penetrating keratoplasty 显示文摘 | Akova YA Onat M Koc F | 1999 | Ophthalmic Surg Lasers1999，30，6： | 1 |
| 11 | Fibrin glue versus sutures for conjunctival autografting in pterygium surgery:a prospective comparative study 显示文摘 | Karalezli A Kucukerdonmez C Akova YA | 2008 | Br J Ophthalmol2008，92，9： | 1 |
| 12 | ESCMID and ECMM joint clinical guidelines for the diagnosis and management of rare invasive yeast infections 显示文摘 | Arendrup MC Boekhout T Akova M | 2014 | Clin Microbiol Infect2014，203，： | 1 |
| 13 | Effect on astigmatism of the location of clear corneal incision in phacoemulsification of cataract 显示文摘 | Altan-Yaycioglu R Akova YA Akca S Gur S Oktem C | 2007 | J Refract Surg2007，23，5： | 1 |
| 14 | Comparison of conjunctival autograft with amniotic membrane transplantation for pterygium surgery:Surgical and cosmetic outcome显示文摘 | Kü(c)ükerd(o)nmez C Akova Y A Altin(o)rs D D | | 0，，04： | 1 |
| 15 | Intracameral triamcinolone acetonide to control postoperative inflammation following cataract surgery with phacoemulsification显示文摘 | Karalezli A Borazan M Akova YA | 2008 | Acta Ophthalmol2008，86，2： | 1 |
| 16 | Evaluation of ocular surface changes in a rabbit dry eye model using a modified impression cytology technique 显示文摘 | Altinors DD Bozbeyoglu S Karabay G Akova YA | 2007 | Curr Eye Res2007，32，4： | 1 |
| 17 | Risk assessment and prognostic factors for moud-related diseases in immunocompromised patients显示文摘 | Pagano L Akova M Dimopoulos G | 2011 | J Antimicrob Chemother2011，66，1： | 1 |
| 18 | Comparison of Jensen's Procedure Combined with Recession of Antagonist Medial Rectus Muscle or Botulinum Toxin Injection into Antagonist Medial Rectus Muscle:Outcome in A Patient with Bilateral Sixth Nerve Palsy显示文摘 | Emel Basar Halit Oguz Nilufer Akova | | 0，，1： | 1 |
| 19 | Reactivity and structure investigation of coals in reaction with dienophiles显示文摘 | G Zher'akova R Kochkan'an | 1990 | Fuel1990，69，： | 1 |
| 20 | Correlation of in vitrofluconazole susceptibility with clinical outcome for severely III patients with oropharyngeal candidiasis显示文摘 | Arikan S Akova M Hayran M | 1998 | Clin Infect Dis1998，26，： | 1 |
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