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您的检索式：作者名="Akiko Taguchi"
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| 1 | Involvement of insulin receptor substrates in cognitive impairment and Alzheimer’s disease显示文摘Type 2 diabetes一associated with impaired insulin/insulin-like growth factor-1 (IGF1) signaling (IIS)一is a risk factor for cognitive impairment and dementia including Alzheimer's disease (AD). The insulin receptor substrate (IRS) proteins are major components of IIS, which transmit upstream signals via the insulin receptor and/or IGF1 receptor to multiple intracellular signaling pathways, including AKT/protein kinase B and extracellular-signal-regulated kinase cascades. Of the four IRS proteins in mammals, IRS1 and IRS2 play key roles in regulating growth and survival, metabolism, and aging. Meanwhile, the roles of IRS1 and IRS2 in the central nervous system with respect to cognitive abilities remain to be clarified. In contrast to IRS2 in peripheral tissues, inactivation of neural IRS2 exerts beneficial effects, resulting in the reduction of amyloid p accumulation and premature mortality in AD mouse models. On the other hand, the increased phosphorylation of IRS 1 at several serine sites is observed in the brains from patients with AD and animal models of AD or cognitive impairment induced by type 2 diabetes. However, these serine sites are also activated in a mouse model of type 2 diabetes, in which the diabetes drug metformin improves memory impairment. Because IRS1 and IRS2 signaling pathways are regulated through complex mechanisms including positive and negative feedback loops, whether the elevated phosphorylation of IRS1 at specific serine sites found in AD brains is a primary response to cognitive dysfunction remains unknown. Here, we examine the associations between IRS 1 /1 RS2-mediated signaling in the central nervous system and cognitive decline. | Daisuke Tanokashira Wataru Fukuokaya Akiko Taguchi | 2019 | Neural Regeneration Research2019，14，8： | 8 |
| 2 | Effect of CYP2D6*10 on pharmacokinetic variability of routinely administered metoprolol in middle-aged and elderly Japanese patients显示文摘 | Masato Taguchi Takashi Nozawa Tomoki Kameyama Hiroshi Inoue Chihiro Takesono Akiko Mizukami Yukiya Hashimoto | 2003 | European Journal of Clinical Pharmacology (-)2003，，5： | 1 |
| 3 | Activation of neurogenesis in the hippocampus is a novel therapeutic target for Alzheimer's disease显示文摘The pathologies associated with age-related brain dysfunction,including Alzheimer's disease(AD),Parkinson's disease,Lewy body dementia,and vascular dementia,often share similarities across multiple diseases.1 While various factors,such as amyloidβ,Tau protein,α-synuclein,chronic inflammation,and impaired cerebral microcirculation have been suggested as potential therapeutic targets,addressing a single factor is unlikely to be sufficient in preventing or treating age-related brain dysfunction.Drawing from these observations. | Akihiko Taguchi Yuka Okinaka Akiko Takeda Takayuki Okamoto Johannes Boltze Carsten Claussen Sheraz Gul | 2023 | Neuroprotection2023，1，2： | 0 |
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