|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intraarticular injections(corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis显示文摘Osteoarthritis(OA)is a complex'whole joint'disease pursued by inflammatory mediators,rather than purely a process of'wear and tear'.Besides cartilage degradation,synovitis,subchondral bone remodeling,degeneration of ligaments and menisci,and hypertrophy of the joint capsule take parts in the pathogenesis.Pain is the hallmark symptom of OA,but the extent to which structural pathology in OA contributes to the pain experience is still not well known.For the knee OA,intraarticular(IA)injection(corticosteroids,viscosupplements,blood-derived products)is preferred as the last nonoperative modality,if the other conservative treatment modalities are ineffective.IA corticosteroid injections provide short term reduction in OA pain and can be considered as an adjunct to core treatment for the relief of moderate to severe pain in people with OA.IA hyaluronic acid(HA)injections might have efficacy and might provide pain reduction in mild OA of knee up to 24 wk.But for HA injections,the costeffectiveness is an important concern that patients must be informed about the efficacy of these preparations.Although more high-quality evidence is needed,recent studies indicate that IA platelet rich plasma injections are promising for relieving pain,improving knee function and quality of life,especially in younger patients,and in mild OA cases.The current literature and our experience indicate that IA injections are safe and have positive effects for patient satisfaction.But,there is no data that any of the IA injections will cause osteophytes to regress or cartilage and meniscus to regenerate in patients with substantial and irreversible bone and cartilage damage. | Egemen Ayhan Hayrettin Kesmezacar Isik Akgun | 2014 | World Journal of Orthopedics2014，5，3： | 36 |
| 2 | Ameliorative effects of bombesin and neurotensin on trinitrobenzene sulphonic acid-induced colitis,oxidative damage and apoptosis in rats显示文摘AIM:To investigate the effects of bombesin (BBS) and neurotensin (NTS) on apoptosis and colitis in an ulcerative colitis model. METHODS:In this study, a total of 50 rats were divided equally into 5 groups. In the control group, no colitis induction or drug administration was performed. Colitis was induced in all other groups. Following the induction of colitis, BBS, NTS or both were applied to three groups of rats. The remaining group (colitis group) received no treatment. On the 11th d after induction of colitis and drug treatment, blood samples were collected for TNF-α and IL-6 level studies. Malondialdehyde (MDA), carbonyl, myeloperoxidase (MPO) and caspase-3 activities, as well as histopathological findings, evaluated in colonic tissues. RESULTS:According to the macroscopic and microscopic findings, the study groups treated with BBS, NTS and BBS + NTS showed significantly lower damage and inflammation compared with the colitis group (macroscopic score, 2.1 ± 0.87, 3.7 ± 0.94 and 2.1 ± 0.87 vs 7.3 ± 0.94;microscopic score, 2.0 ± 0.66, 3.3 ± 0.82 and 1.8 ± 0.63 vs 5.2 ± 0.78, P < 0.01). TNF-α and IL-6 levels were increased significantly in all groups compared with the control group. These increases were significantly smaller in the BBS, NTS and BBS + NTS groups compared with the colitis group (TNF-α levels, 169.69 ± 53.56, 245.86 ± 64.85 and 175.54 ± 42.19 vs 556.44 ± 49.82;IL-6 levels, 443.30 ± 53.99, 612.80 ± 70.39 and 396.80 ± 78.43 vs 1505.90 ± 222.23, P < 0.05). The colonic MPO and MDA levels were significantly lower in control, BBS, NTS and BBS + NTS groups than in the colitis group (MPO levels, 24.36 ± 8.10, 40.51 ± 8.67 and 25.83 ± 6.43 vs 161.47 ± 38.24;MDA levels, 4.70 ± 1.41, 6.55 ± 1.12 and 4.51 ± 0.54 vs 15.60 ± 1.88, P < 0.05). Carbonyl content and caspase-3 levels were higher in the colitis and NTS groups than in control, BBS and BBS + NTS groups (carbonyl levels, 553.99 ± 59.58 and 336.26 ± 35.72 vs 209.76 ± 30.92, 219.76 ± 25.77 and 220.34 ± 36.95;caspase-3 levels, 451.70 ± 68.27 and 216.20 ± 28.17 vs 28.60 ± 6.46, 170.50 ± 32.37 and 166.50 ± 30.95, P < 0.05). CONCLUSION:The results of this study suggest BBS and NTS, through their anti-inflammatory actions, support the maintenance of colonic integrity and merit consideration as potential agents for ameliorating colonic inflammation. | Alper Akcan Sebahattin Muhtaroglu Hulya Akgun Hizir Akyildiz Can Kucuk Erdogan Sozuer Alper Yurci Namik Yilmaz | 2008 | World Journal of Gastroenterology2008，14，8： | 14 |
| 3 | Predictability of outcome of caustic ingestion by esophagogastroduodenoscopy in children显示文摘AIM: To assess the necessity of esophagogastroduodenoscopy (EGD) to predict the outcome of caustic ingestion in children. METHODS: The study included 206 children who underwent EGD because of ingestion of caustic substances between January 2005 and August 2010. Retrospective analysis of data of the patients was performed. RESULTS: The male/female ratio was 1.6 and mean age was 38.1 ± 28.8 mo. The caustic substances were acidic in 72 (34.9%) cases, alkaline in 56 (27.2%), liquid household bleach in 62 (30.1%), and unknown in 16 (7.8%). Fifty-seven (27.7%) patients were symptom-free. Significant clinical findings were observed in 149 (72.3%) patients. Upper gastrointestinal endoscopy findings of esophageal injury were grade 0 in 86 (41.7%) patients, grade 1 in 49 (23.8%), grade 2a in 42 (20.4%), grade 2b in 28 (13.6%), and grade 3a in 1 (0.5%) patient. 35 patients with grade 2a, 2b, and 3a injuries underwent esophageal dilation at second week of ingestion. Esophageal stricture, which necessitated a regular dilation program developed in 13 of the aforementioned 35 patients. There is no statistically significant difference in the rate of development of esophageal stricture between the patients who ingested acidic (15.3%) and alkaline (8.9%) substances (P = 0.32). Severe gastric injury was detected in 38 (18.5%) patients. The rate of development of gastric injury was significantly higher in the acidic group (14%) than in the alkaline group (2.9%) (P = 0.001). Out of 149 patients with clinical findings, 49 (32.9%) patients had no esophageal injury and 117 (78.5%) patients had no gastric lesion. Esophageal and severe gastric injuries were detected in 20 (35.1%) and 8 (14%) of patients with no clinical findings respectively. Pyloric stenosis developed in 6 patients. Pyloric obstruction improved with balloon dilation in 2 patients. Mean hospitalization time were 1.2 ± 0.5 d for grade 0 and 2.3 ± 5 d for grade 1 and 6.3 ± 6.2 d for grade 2a and 15.8 ± 18.6 d for grade 2b. It was significantly longer for patients with grade 2a and 2b injuries (P = 0.000). CONCLUSION: Endoscopy is an effective technique for determining the presence of esophageal and gastric damage and to avoid unnecessary treatment in patients with no or mild injury. | Abdulkerim Temiz Pelin Oguzkurt Semire Serin Ezer Emine Ince Akgun Hicsonmez | 2012 | World Journal of Gastroenterology2012，18，10： | 8 |
| 4 | Melatonin reduces bacterial translocation and apoptosis in trinitrobenzene sulphonic acid-induced colitis of rats显示文摘AIM: To investigate the effects of exogenous melatonin on bacterial translocation and apoptosis in a rat ulcerati-ve colitis model. METHODS: Rats were randomly assigned to three groups: groupⅠ: control, group Ⅱ: experimental colitis, group Ⅲ: colitis plus melatonin treatment. On d 11 after colitis, plasma tumor necrosis factor-α, portal blood endotoxin levels, colon tissue myeloperoxidase and caspase-3 activity were measured. Bacterial translocation was quantified by blood, lymph node, liver and spleen culture. RESULTS: We observed a significantly reduced inciden-ce of bacterial translocation to the liver, spleen, mesen-teric lymph nodes, portal and systemic blood in animals treated with melatonin. Treatment with melatonin signifi-cantly decreased the caspase-3 activity in colonic tissues compared to that in trinitrobenzene sulphonic acid-trea-ted rats (16.11 ± 2.46 vs 32.97 ± 3.91, P < 0.01). CONCLUSION: Melatonin has a protective effect on ba-cterial translocation and apoptosis. | Alper Akcan Can Kucuk Erdogan Sozuer Duygu Esel Hizir Akyildiz Hulya Akgun Sabahattin Muhtaroglu Yucel Aritas | 2008 | World Journal of Gastroenterology2008，14，6： | 5 |
| 5 | Assessment of rock slope stability by probabilistic-based Slope Stability Probability Classification method along highway cut slopes in Adilcevaz-Bitlis(Turkey)显示文摘Rock slope stability is of great concern along highway routes as stability problems on cut slopes may cause fatal events as well as loss of property.In rock slope engineering,stability evaluations are commonly performed by means of analytical or numerical analyses,principally considering the factor of safety concept.As a matter of fact,the probabilistic assessment of slope stability is progressively getting popularity due to difficulties in assigning the most appropriate values to design parameters in analytical or numerical methods.Additionally,the effect of heterogeneities in rock masses and discontinuities on the analysis results is minimized through the probabilistic concept.In this study,slope stability of high and steep sedimentary rock cut slopes along a state highway in AdilcevazBitlis(Turkey) was evaluated on the basis of probabilistic approach using the Slope Stability Probability Classification(SSPC) system.The probabilistic assessment indicates major slope stability problems because of discontinuity controlled and discontinuity orientation independent mass movements.Almost all studied cut slopes suffer from orientation-independent stability problems with very low stability probabilities.Additionally,the probability of planar and toppling failures issignificantly high with respect to the SSPC system.The stability problems along the investigated rock slopes were also verified by field reconnaissance.Remedial measures such as slope re-design and reinforcement at the studied locations should be taken to prevent hazardous events along the highway.On the other hand,the probabilistic approach may be a useful tool during rock slope engineering to overcome numerous uncertainties when probabilistic and analytic results are compared. | Akgun CANAL Mutluhan AKIN | 2016 | Journal of Mountain Science2016，13，11： | 4 |
| 6 | Malformations of cortical development:3T magnetic resonance imaging features显示文摘Malformation of cortical development(MCD) is a term representing an inhomogeneous group of central nervous system abnormalities, referring particularly to embriyological aspect as a consequence of any of the three developmental stages, i.e., cell proliferation, cell migration and cortical organization. These include cotical dysgenesis, microcephaly, polymicrogyria, schizencephaly, lissencephaly, hemimegalencephaly, heterotopia and focal cortical dysplasia. Since magnetic resonance imaging is the modality of choice that best identifies the structural anomalies of the brain cortex, we aimed to provide a mini review of MCD by using 3T magnetic resonance scanner images. | Bilal Battal Selami Ince Veysel Akgun Murat Kocaoglu Emrah Ozcan Mustafa Tasar | 2015 | World Journal of Radiology2015，7，10： | 2 |
| 7 | Factors affecting mortality of Fourn-ie' rs gangrene: review of 70 patients显示文摘 | Ersay A Yihnaz C Akgun Y | 2007 | ANZ J Surg2007，77，12： | 1 |
| 8 | Effect of some protein based fat replacers on physical,chemical,textural,and sensory properties of strained yoghurt显示文摘 | Yazici Akgun A | 2004 | Journal of Food Engineering2004，62，： | 1 |
| 9 | On the influence of single grit micro-geometry on grinding behavior of ductile and brittle materials显示文摘 | AXINTE D BUTLER-SMITH P AKGUN C | | International Journal of Machine Tools & Manufacture0，4，8： | 1 |
| 10 | Intra-articular hemangioma of the knee显示文摘 | Akgun I Kesmezacar H Ogut T | 2003 | Arthroscopy2003，19，3： | 1 |
| 11 | Decay of maternally derived measles anti- body in central Turkey显示文摘 | Metintas S Akgun Y Arslantas D | 2002 | Public Health2002，116，： | 1 |
| 12 | Effect of Post-Oxidizing on Tribological and Corrosion Behaviour of Plasma Nitrided AISI 5140 Steel显示文摘 | Akgun Alsaran Hikmet Altun Mehmet Karakan | 2004 | Surface and Coatings Technology2004，176，： | 1 |
| 13 | The association of human leukocyte antigen pol-ymorphisms with disease severity and latency period in patients with silicosis显示文摘 | Dogan H Akgun M Araz O | | 0，，： | 1 |
| 14 | The association of human leuko- eyte antigen polymorphisms with disease severity and lateney period in patients with silicosis显示文摘 | Dogan H Akgun M Araz O | 2014 | Muhidiseip Respir Med2014，9，1： | 1 |
| 15 | Unbiased estimation of tumor regression rates during chemoradiotherapy for esophageal carcinoma using CT and stereology显示文摘 | Okur A Kantarci M Akgun M | | 0，，02： | 1 |
| 16 | Postharvest ethanol and potassium sorbate treatments of table grapes to control gray mold显示文摘 | Ozgur Akgun Karabulut Gianfranco Romanazzi Joseph L. Smilanick Amnon Lichter | 2005 | Postharvest Biology and Technology2005，，2： | 1 |
| 17 | Learning process in new product development teams and effects on product success: A socio-cognitive perspective显示文摘 | Akgun A Lynn G S Yilmaz C | 2006 | Industrial Marketing Man- agement2006，35，2： | 1 |
| 18 | Postharvest ethanol and hot water treatments of table grapes to control gray mold显示文摘 | Ozgur Akgun Karabulut Franka Mlikota Gabler Monir Mansour Joseph L. Smilanick | 2004 | Postharvest Biology and Technology2004，，2： | 1 |
| 19 | Differential diagnosis of carpal tunnel syndrome显示文摘 | Akgun H Yucel M Oz O | 2014 | Turk Neurosurg2014，24，1： | 1 |
| 20 | Two-level composite wing structural optimization using response surface 显示文摘 | Liu B Haftka R T Akgun M A | 2000 | Struct Multidisc Optim2000，20，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员