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| 1 | Midkine secretion protects Hep3B cells from cadmium induced cellular damage显示文摘AIM: To evaluate role of midkine secretion during Cadmium (Cd) exposure in the human hepatocyte cell line Hep3B cells. METHODS: Different dosages of Cd (0.5-1-5-10 μg/mL) were applied to Hep3B cells and their effects to apoptosis, lactate dehydrogenase (LDH) leakage and midkine secretion were evaluated as time dependent manner. Same experiments were repeated with exogenously applied midkine (250-5000 pg/mL) and/or 5 μg/mL Cd.RESULTS: Cd exposure induced prominent apoptosis and LDH leakage beginning from lower dosages at the 48th h. Cd induced midkine secretion with higher dosages (P < 0.001), (control, Cd 0.5-1-5-10 μg/mL respectively: 1123 ± 73, 1157 ± 63, 1242 ± 90, 1886 ± 175, 1712 ± 166 pg/mL). Exogenous 500-5000 pg/mL midkine application during 5 μg/mL Cd toxicity prevented caspase-3 activation (control, Cd toxicity, 250, 500, 1000, 2500, 5000 pg/mL midkine+ Cd toxicity, respectively: 374 ± 64, 1786 ± 156, 1545 ± 179, 1203 ± 113, 974 ± 116, 646 ± 56, 556 ± 63 cfu) LDH leakage and cell death in Hep3B cells (P < 0.001). CONCLUSION: Our results showed that midkine secretion from Hep3B cells during Cd exposure protects liver cells from Cd induced cellular damage. Midkine has anti-apoptotic and cytoprotective role during Cd toxicity. Further studies are needed to explain the mechanism of midkine secretion and cytoprotective role of midkine during Cd exposure. Midkine may be a promising theurapatic agent in different toxic hepatic diseases. | Nuray Yazihan Haluk Ataoglu Ethem Akcil Burcu Yener Bulent Salman Cengiz Aydin | 2008 | World Journal of Gastroenterology2008，14，1： | 2 |
| 2 | Acid Mine Drainage (AMD): causes, treatment and case studies显示文摘 | Ata Akcil Soner Koldas | 2005 | Journal of Cleaner Production2005，，12： | 2 |
| 3 | Aqueous metal recovery techniques from e-scrap: Hydrometallurgy in recycling显示文摘 | A. Tuncuk V. Stazi A. Akcil E.Y. Yazici H. Deveci | 2011 | Minerals Engineering2011，，1： | 2 |
| 4 | Potential bioleaching developments towards commercial reality:Turkish metal mining's future显示文摘 | Akcil A | 2004 | Minerals Engineering2004，17，： | 1 |
| 5 | Aqueous metal recovery techniques from e-scrap: Hydrometallurgy in recycling 显示文摘 | TUNCUK A STAZI V AKCIL A YAZICI E Y DDEVECI H | 2012 | Minerals Engineering2012，25，： | 1 |
| 6 | Acid Mine Drainage (AMD): causes, treatment and case studies 显示文摘 | Akcil A Koldas S | 2006 | Journal of Cleaner Production2006，14，1213： | 1 |
| 7 | Destruction of cyanide in gold mill effluents: biological versus chemical treatments显示文摘 | Ata Akcil | 2003 | Biotechnology Advances2003，，6： | 1 |
| 8 | Bioleaching of complex zinc sulphides using mesophilic and thermophilic bacteria:Comparative importance of pH and iron显示文摘 | Deveci H Akcil A Alp I | 2004 | Hydrometallurgy2004，73，34： | 1 |
| 9 | Acid Mine Drainage (AMD): cause, treatment and case studies显示文摘 | Akcil A Koldas S | 2006 | Journai of Cleaner Production2006，14，1213： | 1 |
| 10 | Potential bioleaching developments towards commercial reality显示文摘 | AKCIL A | 2004 | Minerals Engineering2004，17，： | 1 |
| 11 | A review of technologies for the recovery of metals from spent alkaline and zinc-carbon batteries显示文摘 | SAYILGAN E KUKRER T CIVELEKOGLU G FERELLA F AKCIL A VEGLIO F KITIS M | 2009 | Hydrometallurgy2009，97，： | 1 |
| 12 | The effects of L-carnitine treatment on left ventricular function and erythrocyte superoxide dismutase activity in patients with ischemic cardiomyopathy显示文摘 | Gurlek A Tutar E Akcil E | 2000 | Eur J Heart Fail2000，2，2： | 1 |
| 13 | Role of cytological characteristics of benign thyroid nodules on effectiveness of their treatment with levothyroxine显示文摘 | Cesur M Akcil M Ertek S | 2013 | Arch Med Sci2013，9，6： | 1 |
| 14 | Acid Mine Drainage (AMD) : Causes, treatment and case studies 显示文摘 | Akcil A Koldas S | 2006 | Journal of Cleaner Production2006，14，： | 1 |
| 15 | Destruction of cyanide in gold mill effluents:biological versus chemical treatments显示文摘 | Ata Akcil | 2003 | Biotechnology Advances2003，21，6： | 1 |
| 16 | Role and contribution of pure and mixed cultures of mesophiles in bioleaching of a pyritic chalcopyrite concentrate显示文摘 | AKCIL A CIFTCI H DEVECI H | | 0，，： | 1 |
| 17 | Potential bioleaching developments towards commercial reality: Turkish metal mining's future显示文摘 | AKCIL A | 2004 | Minerals Engineering2004，17，3： | 1 |
| 18 | Potential b~oleaching developments towards commercial reality: Turkish metal mining's future 显示文摘 | Akcil A | 2004 | Minerals Engineering2004，17，3： | 1 |
| 19 | Bioleaching of complex zinc sulphides using mesophilic and thermophilic bacteria: Comparative importance of pH and iron 显示文摘 | DEVECI H AKCIL A ALP I | 2004 | Hydrometallurgy2004，73，3： | 1 |
| 20 | Acid Mine Drainage(AMD):Causes,treatment and case studies显示文摘 | Ata Akcil Soner Koldas | 2006 | Journal of Cleaner Production2006，14，： | 1 |
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