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| 1 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 2 | Relation of atrophic gastritis with Helicobacter pylori-CagA^+ and interleukin-1 gene polymorphisms显示文摘AIM: To determine the association of Helicobacter pylori (H pylori) CagA+ infection and pro-inflammatory poly-morphisms of the genes interleukin (IL)-1RN and IL-1B with the risk of gastric atrophy and peptic ulcers in a dyspeptic population in Costa Rica, a country with high incidence and mortality of gastric cancer. METHODS: Seven biopsy specimens, a fasting blood sample and a questionnaire concerning nutritional and sociodemographic factors were obtained from 501 con-secutive patients who had undergone endoscopy for dyspeptic symptoms. A histopathological diagnosis was made. Pepsinogen concentrations were analyzed by enzyme linked immunosorbent assay (ELISA). Infection with H pylori CagA+ was determined by serology and polymerase chain reaction (PCR). IL-1B and IL-1RN polymorphisms genotyping was performed by PCR-restriction fragment length polymorphism (PCR-RFLP)and PCR respectively. RESULTS: In this dyspeptic population, 86% were H pylori positive and of these, 67.8% were positive for CagA. Atrophic antral gastritis (AAG) was associated with CagA+ status [odd ratio (OR) = 4.1; P < 0.000] and fruit consumption (OR = 0.3; P < 0.00). Atrophic body gastritis (ABG) was associated with pepsinogen PGI/PGII < 3.4 (OR = 4.9; P < 0.04) and alcohol consumption (OR = 7.3; P < 0.02). Duodenal ulcer was associated with CagA+ (OR = 2.9; P < 0.04) and smoking (OR = 2.4; P < 0.04). PGI < 60 μg/L as well as PGI/PGII < 3.4 were associated with CagA+. CONCLUSION: In a dyspeptic population in Costa Rica, H pylori CagA+ is not associated with ABG, but it is a risk factor for AAG. The pro-inflammatory cytokine poly-morphisms IL-1B + 3945 and IL-1RN are not associated with the atrophic lesions of this dyspeptic population. | Rafaela Sierra Clas Une Vanessa Ramírez Warner Alpízar-Alpízar María I González José A Ramírez Antoine de Mascarel Patricia Cuenca Guillermo Pérez-Pérez Francis Mégraud | 2008 | World Journal of Gastroenterology2008，14，42： | 2 |
| 3 | Colour Doppler imaging of the orbital vasculature in Graves' disease with computed tomographic correlation显示文摘 | Alp MN Ozgen A Can I | 2000 | BrJ Ophthalmol2000，84，9： | 1 |
| 4 | The respiratory NADH dehydrogenase of the cyanobacterium Anabaena vadabilis: purification and characterization显示文摘 | Alpes I Scherer S BOger P | 1989 | Biocllim Biopllys Acta1989，973，1： | 1 |
| 5 | Bioleaching of complex zinc sulphides using mesophilic and thermophilic bacteria:Comparative importance of pH and iron显示文摘 | Deveci H Akcil A Alp I | 2004 | Hydrometallurgy2004，73，34： | 1 |
| 6 | Ant colony opimization for the single modelU-type assembly line balancing problem显示文摘 | Sabuncuoglu I Erel E Alp A | 2009 | International Journal ofProduction Economics2009，120，2： | 1 |
| 7 | Approaches to the reversal of malnutrition, inflammation, and atherosclerosis in end- stage renal disease显示文摘 | Kayser C Raymond M H Alp I | 2002 | Nutrition Reviews2002，60，11： | 1 |
| 8 | Potential Use of Pyrite Cinders as Raw Material in Cement Production: Results of Industrial Scale Trial Operations 显示文摘 | Alp I Deveci H YazlcI E Y | 2009 | Journal of Hazardous Materials2009，1660，： | 1 |
| 9 | Oxidative DNA damage in patients with cataract显示文摘 | Ates O Alp HH Kocer I | 2010 | Acta Ophthalmol2010，88，： | 1 |
| 10 | Bioleaching of complex zinc sulphides using mesophilic and thermophilic bacteria: Comparative importance of pH and iron 显示文摘 | DEVECI H AKCIL A ALP I | 2004 | Hydrometallurgy2004，73，3： | 1 |
| 11 | Arsenic Removal from Aqueous Solutions with Fe-Hydrotalcite Supported Magnetite Nanoparticle显示文摘 | TURK T ALP I | 2014 | Journal of Industrial and Engineering Chemistry2014，20，2： | 1 |
| 12 | Potential use of pyrite cin- dera as raw material in cement production : Results of industri- al scale trial operations显示文摘 | Alp I Deveei H Yazici E Y | 2009 | Journal of Hazardous Materials2009，166，： | 1 |
| 13 | Potential use of pyrite cinders as raw material in cement production:results of industrial scale trial operations显示文摘 | ALP I DEVECI H YAZICI E Y | 2009 | Journal of Hazardous Materials2009，166，1： | 1 |
| 14 | Coloun Doppler imagine of the orbital vasculature in Graves'disease with computed tomographic correlation 显示文摘 | Alp MN Ozgen A Can I | 2000 | Br J Ophthalmol2000，84，9： | 1 |
| 15 | Oxidativc DNA damage in retinopathy of prematurity显示文摘 | Ates O Alp HH Caner I | 2009 | Eur J Ophthalmol2009，19，1： | 1 |
| 16 | Potential Use of Pyrite Cinders as Raw Material in Cement Production:Results of Industrial Scale Trial Operations显示文摘 | Devecia I Alp H Yaz? c? a E Y Türka T | 2009 | Journal of Hazardous Materials2009，166，1： | 1 |
| 17 | Oxidative DNA damage in retinopathy of prematurity显示文摘 | Ates O Alp HH Caner I Yildirim A Tastekin A Kocer I | 2009 | Eur J Ophthalmol2009，19，1： | 1 |
| 18 | The effects of the pre-treatment of intravenous nimodipine on Na ^+ - K ^+/ATPase, Ca^2 +/Mg^2+ AT- Pase, Lipid peroxidation and early uhrastructural findings following- middle cerebral after occlusion in the rat显示文摘 | Faruk I Alp IG Metin T | 2001 | Stroke2001，23，： | 1 |
| 19 | Removal of cyanide from aqueous solutions by plainand metal-impregnated granu-lar activated carbons显示文摘 | DEVECI H YAZICI E Y ALP I | | 0，，： | 1 |
| 20 | Potential use of pyrite cinders as raw material in cement production:Results of industrial scale trial operations 显示文摘 | Alp I Deveei H Yaziei E Y | 2009 | Journal of Hazardous Materials2009，166，： | 1 |
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