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1Current adjuvant treatment modalities for gastric cancer:From history to the future显示文摘The discrepancy between the surgical technique and the type of adjuvant chemotherapy used in clinical trials and patient outcomes in terms of overall survival rates has led to the generation of different adjuvant treatment protocols in distinct parts of the world.The adjuvant treatment recommendation is generally chemoradiotherapy in the United States,perioperative chemotherapy in the United Kingdom and parts of Europe,and chemotherapy in Asia.These options mainly rely on the United States Intergroup-0116,United Kingdom British Medical Research Council Adjuvant Gastric Infusional Chemotherapy,and the Asian Adjuvant Chemotherapy Trial of S-1 for Gastric Cancer and Capecitabine and Oxaliplatin Adjuvant Study in Stomach Cancer trials.However,the benefits were evident for only certain patients,which were not very homogeneous regarding the type of surgery,chemotherapy regimens,and stage of disease.Whether the dissimilarities in survival are attributable to surgical technique or intrinsic biological differences is a subject of debate.Regardless of the extent of surgery,multimodal therapy may offer modest survival advantage at least for diseases with lymph node involvement.Moreover,in the era of individualized treatment for most of the other cancer types,identification of special subgroups comprising those who will derive more or no benefit from adjuvant therapy merits further investigation.The aim of this review is to reveal the historical evolution and future reflections of adjuvant treatment modalities for resected gastric cancer patients.Leyla Kilic Cetin Ordu Ibrahim Yildiz Fatma Sen Serkan Keskin Rumeysa Ciftci Kezban Nur Pilanci 2016World Journal of Gastrointestinal Oncology2016,8,5:9
2Interaction between seed size and NaCl on germination and early seedling growth of some Turkish cultivars of chickpea(Cicer arietinum L.)显示文摘Chickpea is an important food legume crop of Turkey and is largely grown for human consumption on low moisture or salt-affected soils. The objective of the study was to find the effects of NaCl stress at electrical conductivities of 4.5,8.6,12.7 and 16.3 dS/m and seed sizes(7,8 and 9 mm) on germination and early seedling growth of three popular chickpea cultivars(AKN-97,Gokce and Uzunlu-99). Mean frequency of germination,germination time,germination index,root length,shoot length and seedling fresh weight showed seed size-dependent responses of cultivars to salt stress. In general,small seeds germinated and grew more rapidly compared to medium and large seeds of the same cultivars against all levels of salt stress,with the best results in cultivar Uzunlu-99. No effect of NaCl treatments was observed on frequency of germination;however,a drastic decrease in early seedling growth was recorded at increased NaCl concentrations. Regression analysis results showed a significantly positive rela-tionship(P<0.01) between seed size and mean germination time,whereas a significantly negative relationship was recorded between seed size and germination index,root length,shoot length. Moreover,linear regression values apparently confirmed that increased seed size in each cultivar affected decreased germination index,root and shoot lengths with enhanced mean germination time. Thus,it was concluded that the use of small seeds could considerably reduce the production costs of chickpea in salt-affected soils.Muharrem KAYA Gamze KAYA Mehmet Demir KAYA Mehmet ATAK Sevil SAGLAM Khalid Mahmood KHAWAR Cemalettin Yasar CIFTCI 2008Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008,9,5:8
3Prolonged QT dispersion in inflammatory bowel disease显示文摘AIM:To investigate the frequency and factors of prolonged QT dispersion that may lead to severe ventricular arrhythmias in patients with inflammatory bowel disease(IBD).METHODS:This study included 63 ulcerative colitis(UC) and 41 Crohn's disease(CD) patients.Forty-seven healthy patients were included as the control group.Heart rate was calculated using electrocardiography,corrected QT dispersion(QTcd) and the Bazett's formula.Homeostasis model assessment(HOMA) was used to determine insulin resistance(IR).HOMA values < 1 were considered normal and values > 2.5 indicated a high probability of IR.RESULTS:Prolonged QTcd was found in 12.2% of UC patients,and in 14.5% of CD patients compared with the control group(P < 0.05).A significant difference was found between the insulin values(CD:10.95 ± 6.10 vs 6.44 ± 3.28,P < 0.05;UC:10.88 ± 7.19 vs 7.20 ± 4.54,P < 0.05) and HOMA(CD:2.56 ± 1.43 vs 1.42 ± 0.75,P < 0.05;UC:2.94 ± 1.88 vs 1.90 ± 1.09,P < 0.05) in UC and CD patients with and without prolonged QTcd.Disease behavior types were determined in CD patients with prolonged QTcd.Increased systolic arterial pressure(125 ± 13.81 vs 114.09 ± 8.73,P < 0.01) and age(48.67 ± 13.93 vs 39.57 ± 11.58,P < 0.05) in UC patients were significantly associated with prolonged QTcd.CONCLUSION:Our data show that IBD patients have prolonged QTcd in relation to controls.The routine followup of IBD patients should include determination of HOMA,insulin values and electrocardiogram examination.Elif Yorulmaz Aslihan Sezgin Gupse Adali Hatice Yorulmaz Hilmi Ciftci 2013World Journal of Gastroenterology2013,19,1:8
4Laparoscopic vs mini-incision open appendectomy显示文摘AIM: To compare laparoscopic vs mini-incision open appendectomy in light of recent data at our centre.METHODS: The data of patients who underwen appendectomy between January 2011 and June 2013 were collected. The data included patients' demographic data, procedure time, length of hospital stay, the need for pain medicine, postoperative visual analog scale o pain, and morbidities. Pregnant women and patients with previous lower abdominal surgery were excluded Patients with surgery converted from laparoscopic appendectomy(LA) to mini-incision open appendectomy(MOA) were excluded. Patients were divided into two groups: LA and MOA done by the same surgeon. The patients were randomized into MOA and LA groups a computer-generated number. The diagnosis of acute appendicitis was made by the surgeon with physica examination, laboratory values, and radiological tests(abdominal ultrasound or computed tomography). Al operations were performed with general anaesthesia The postoperative vision analog scale score was recorded at postoperative hours 1, 6, 12, and 24. Patients were discharged when they tolerated normal food and passed gas and were followed up every week for three weeks as outpatients.RESULTS: Of the 243 patients, 121(49.9%) underwen MOA, while 122(50.1%) had laparoscopic appendectomy There were no significant differences in operation time between the two groups(P = 0.844), whereas the visua analog scale of pain was significantly higher in the open appendectomy group at the 1st hour(P = 0.001), 6th hour(P = 0.001), and 12 th hour(P = 0.027). The need for analgesic medication was significantly higher in the MOA group(P = 0.001). There were no differences between the two groups in terms of morbidity rate(P = 0.599)The rate of total complications was similar between the two groups(6.5% in LA vs 7.4% in OA, P = 0.599). Al wound infections were treated non-surgically. Six ou of seven patients with pelvic abscess were successfully treated with percutaneous drainage; one patient requiredsurgical drainage after a failed percutaneous drainage. There were no differences in the period of hospital stay, operation time, and postoperative complication rate between the two groups. Laparoscopic appendectomy decreases the need for analgesic medications and the visual analog scale of pain.CONCLUSION: The laparoscopic appendectomy should be considered as a standard treatment for acute appendicitis. Mini-incision appendectomy is an alternative for a select group of patients.Fatih Ciftci 2015World Journal of Gastrointestinal Surgery2015,7,10:5
5正常血压、高血压前期和高血压对冠状动脉微血管功能的影响显示文摘背景:利用经胸多普勒超声心动图行冠状动脉血流储备(CFR)评估已被用于临床,CFR降低被认为是高血压终末器官受损的灵敏指标;然而,迄今该方法尚未被用于评估高血压前期受试者的CFR。因此,本研究旨在评估高血压前期受试者的CFR。方法和结果:通过经胸多普勒超声心动图检测40例高血压前期受试者、60例高血压患者和50例血压正常健康志愿者的CFR。所有受试者均无系统性疾病。3组受试者之间年龄、性别、体重指数、心率、血脂、空腹血糖和血红蛋白水平均相似。Erdogan D. Yildirim I. Ciftci O. 徐永城 2007世界核心医学期刊文摘(心脏病学分册)2007,3,7:3
6Ectopic liver tissue (choristoma) on the gallbladder: Acomprehensive literature review显示文摘BACKGROUND Liver tissue situated outside the liver with a hepatic connection is usually calledan accessory liver, and that without a connection to the mother liver, is calledectopic liver tissue.AIM To identify studies in the literature on ectopic liver tissue located on thegallbladder surface or mesentery.METHODS We present two patients and review published articles on ectopic liver tissuelocated on the gallbladder surface accessed via PubMed, MEDLINE, GoogleScholar, and Google databases. Keywords used included accessory liver lobe,aberrant liver tissue, ectopic liver tissue, ectopic liver nodule, heterotopic livertissue, hepatic choristoma, heterotopic liver tissue on the gallbladder, and ectopicliver tissue on the gallbladder. The search included articles published before June2020 with no language restriction. Letters to the editor, case reports, reviewarticles, original articles, and meeting presentations were included in the search.Articles or abstracts containing adequate information on age, sex, history of liverdisease, preliminary diagnosis, radiologic tools, lesion size, surgical indication,surgical procedure, and histopathological features of ectopic liver tissue wereincluded in the study.RESULTS A total of 72 articles involving 91 cases of ectopic liver tissue located on the gallbladder surface or mesentery were analyzed. Of these 91 patients, 62 werefemale and 25 were male (no gender available for 4 patients), and the age rangewas 5 d to 91 years. Forty-nine patients underwent surgery for chroniccholecystitis or cholelithiasis, and 14 patients underwent surgery for acutecholecystitis. The remaining 28 patients underwent laparotomy for other reasons.Cholecystectomy was laparoscopic in 69 patients and open in 11 patients. Theremaining 19 patients underwent various other surgical procedures such asautopsy, liver transplantation, living donor hepatectomy, Whipple procedure, andliver segment V resection. Histopathologically, hepatocellular carcinoma wasdetected in the ectopic liver tissue of one patient.CONCLUSION Ectopic liver tissue is a rare developmental anomaly which is usually detectedincidentally. Although most studies suggest that ectopic liver located outside thegallbladder has a high risk of hepatocellular carcinoma, this is not reflected instatistical analysis.Sami Akbulut Khaled Demyati Felat Ciftci Cemalettin Koc Adem Tuncer Emrah Sahin Nese Karadag Sezai Yilmaz 2020World Journal of Gastrointestinal Surgery2020,12,12:2
7Incarcerated amyand hernia显示文摘Amyand's hernia is a rare condition defined by the inclusion of the appendix vermiformis within the hernia sac. Its incidence among cases of groin hernia is less than 1%. The clinical manifestation of incarcerated inguinal hernia generally masks the symptoms and signs of acute appendicitis, which renders preoperative diagnosis difficult. In this study, we present two cases of Amyand's hernia that were diagnosed preoperatively. The patients were taken for operation with the prediagnosis of ?ncarcerated inguinal hernia. We evaluated these cases along with data from prior studies.Fatih Ciftci Ibrahim Abdulrahman 2015World Journal of Gastrointestinal Surgery2015,7,3:2
8Effects of normal blood pressure,prehypertension,and hypertension on coronary microvascular function显示文摘Erdogan D Yildirim I Ciftci O 2007Circulation2007,115,5:1
9Effect of nasal continuous positive airway pressure in uncontrolled nocturnal asthmatic patients with obstructive sleep apnea syndrome显示文摘Ciftci TU Ciftci B Guven SF 0,,05:1
10Inflammatory myofibroblastic tumor in children: diagnosis and treatment 显示文摘Karnak I Senocak ME Ciftci AO 2001J Pediatr Surg2001,36,:1
11Transpubic urethroplasty in children:report of 10 cases with review of the literature显示文摘SENOCAK M E CIFTCI A O BUYUKPAMUKCU N 1995J Pediatr Surg1995,30,9:1
12Pheochromocytoma in children显示文摘Arbay O Ciftci F Tanyel C 2001J Pediatr Surg2001,36,5:1
13Use of an antibiotic growth promoter and two herbal natural feed additives with and without exogenous enzymes in wheat based broiler diets显示文摘SARICA S CIFTCI A DEMIR E 2005S Afr J Anim Sci2005,35,1:1
14Effect of nasal continuous positive airway pressure in uncontrolled nocturnal asthmatic patients with obstructive sleep apnea syndrome显示文摘Ciftci TU Ciftci B Guven SF 2005Respir Med2005,99,5:1
15Formulation and characterization of Paclitaxe1,5 - FU and Paclitaxel 5 - FU microspheres 显示文摘Gupte Anshul Ciftci K 2004Int J Pharm2004,276,12:1
16Effect of ta-msulosinon the number and intensity of ureteral colicin patients with lower ureteral calculus显示文摘RESIM S EKERBICER H CIFTCI A 2005Int JUrol2005,12,:1
17Right ventricular outflow tract thrombus in a case of Behcet's disease显示文摘Ozer N Ciftci O Demirci M 2005J Am Soc Echocardiogr2005,18,4:1
18The effect of insulin-like growth factor system on embryo growth and development显示文摘Ciftci H B 0,,05:1
19Mild carbon monoxide poisoning impairs left ventricular diastolic function显示文摘Ciftci O Gunday M Call skan M 2013Indian J Crit Care Med2013,17,3:1
20The relationship between high-sensitivity C-reactive protein levels and the severity of obstructive sleep ap-nea显示文摘GUVEN S F TURKKANI M H CIFTCI B 2012Sleep Breath2012,16,:1
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