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| 1 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 2 | Changes in anteri- or segment dimensions over 4 years in a cohort of Siugaporean subjects with open angles显示文摘 | He Y Baskaran M Narayanaswamy AK | 2015 | Br J Ophthalmol2015，13，： | 1 |
| 3 | Systemic delivery of microRNA -181 b inhibits nuclear factor - κB activation, vascular inflammation, and atherosclerosis in apolipoprotein E - deficient mice 显示文摘 | Sun X He S Wara AK | 2014 | Circ Res2014，114，1： | 1 |
| 4 | Identification of differentially expressed mieroRNA in parathyroid tumors显示文摘 | Rahbari R Hollowgy AK He M | | 0，，： | 1 |
| 5 | Nickel-titanium wire in circumferential suture of a flexor tendon repair:a comparison to polypropylene显示文摘 | Karjalainen T He M Chong AK | 2010 | J Hand Surg2010，35，7： | 1 |
| 6 | Nuclear and cytoplasmic accumula- tion of Ep-ICD is frequently detected in human epithelial cancers 显示文摘 | Ralhan R He HC So AK | 2010 | PLoS One2010，5，14： | 1 |
| 7 | Mutations of the opsin gene (Y102H and I307N) lead to light-induced degeneration of photoreceptors and constitutive activation of phototransduction in mice显示文摘 | Budzynski E Gross AK MeAlear SD Peachey NS Shukla M He F | 2010 | J Biol Chem2010，285，14： | 1 |
| 8 | Reproductive and family planning history, knowledge, and needs: A community survey of low-income women in Beijing, China显示文摘 | He H Ostbye T Daltveit AK | 2009 | BMC Womens Health2009，9，： | 1 |
| 9 | Gout current diag-nosis and treatment显示文摘 | Tausche AK Jansen TL Schroder HE | 2009 | Dtsch Arztebl Int2009，106，3435： | 1 |
| 10 | 0 M HC1 solution显示文摘 | HE X K JIANG Y M LI C et ak Inhibition properties and adsorption behavior of imidazole and 2-phenyl-2- imidazoline on AA5052 in 1 | 2014 | Corros Sci2014，83，： | 1 |
| 11 | Nuclear and cytoplasmicaccumulation of Ep-ICD is frequently detected in human epithelialcancers显示文摘 | Ralhan R He HC So AK | 2010 | PLoS One2010，5，11： | 1 |
| 12 | Polymorphism in the promoter region of the NFκB1 gene increases the risk of sporadic colorectal cancer in Swedish but not in Chinese populations显示文摘 | Lewander A Butchi AK Gao J He LI Lindblom A Arbman G | 2007 | Scand J Gastroenterol2007，42，11： | 1 |
| 13 | Systemic delivery of microRNA 181b inhibits NF-kappaB activation, vascular inflammation, and atherosclerosis in apoe- / mice显示文摘 | Sun X He S Wara AK | 2014 | Circ Res2014，114，1： | 1 |
| 14 | The effect of urokinase in preventing the tbrmation of epidural fibrosis and/or leptomeningeal arachnoiditis 显示文摘 | Ceviz A Arslan A Ak HE | 1997 | Surg Neurol1997，47，2： | 1 |
| 15 | Identification of differen- tially expressed microRNA in parathyroid tundra显示文摘 | Rahbari R Holloway AK He M | 2011 | Ann Surg On- col2011，18，4： | 1 |
| 16 | Post-acute brain injury urinary signature:a new resource for molecular diagnostics显示文摘 | Ottens AK Stafflinger JE Griffin HE | 2014 | J Neurotrauma2014，31，8： | 1 |
| 17 | Systemic delivery of microRNA - 181b inhibits nuclear factor- κB activation, vascular inflammation, and ath- erosclerosis in apolipoprotein E- deficient mice显示文摘 | Sun X He S Wara AK | 2014 | Circ Res2014，114，1： | 1 |
| 18 | Structure and ligand of a histone acetyl transferase bromodomain显示文摘 | Dhalluin C Carlson JE Zeng L He C Aggarwal AK Zhou MM | 1999 | Nature1999，399，： | 1 |
| 19 | Gout-current d-iagnos is and treatment显示文摘 | Tausche AK Jansen TL Schrêder HE | 2009 | Dtsch Arztebl Int2009，106，34： | 1 |
| 20 | Effects of prenatal stress on defensive withdrawal behavior and corticotropin releasing factor systems in rat brain显示文摘 | Ward HE Johnson EA Salm AK | 2000 | Physiol Behav2000，70，34： | 1 |
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