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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | 术前检测患者血液中总蛋白、白蛋白与白细胞介素-1受体拮抗剂作为切口疝修补术后是否出现血清肿的预测指标显示文摘患者切口疝修补术后出现血清肿是非常常见的,约占20%~30%,其中10%的患者渗液量超过50ml。出现血清肿并不一定出现并发症,但血清肿患者术后容易出现疼痛不适,尤其是补片感染导致修补手术失败,切口疝复发。对某些患者及时使用细针抽液,甚至是手术治疗都是必要的。 | Klink CD Binnebosel M Lucas AH Schachtrupp A Grommes J Conze J Klinge U Neumann U Junge K 宗振(译) 陈双(校) | 2012 | 中华疝和腹壁外科杂志(电子版)2012，6，2： | 2 |
| 3 | Women at risk for AD show increased parietal activation during a fluency task 显示文摘 | Smith CD Andersen AH Kryscio RJ | 2002 | Neurology2002，58，： | 1 |
| 4 | Imaging of female pelvic malignancies regarding MRI, CT, and PET/CT: Part l显示文摘 | Brocker KA Ah CD Eichbaum M | 2011 | Strahlenther Onkol2011，187，10： | 1 |
| 5 | Incidence and risk fac- tors for stroke in pregnancy and the puerperium显示文摘 | James AH Bushnell CD Jamison MG | 2005 | Obstet Gyneeol2005，106，： | 1 |
| 6 | Altered brain activation incognitively intact individuals at high risk for Alzheimer's disease显示文摘 | Smith CD Andersen AH Kryscio RJ | 1999 | Neurology1999，53，： | 1 |
| 7 | Women at risk for AD show increased parietal activation during a fluency task显示文摘 | Smith CD Andersen AH Kryscio RJ | 2002 | Neurology2002，58，8： | 1 |
| 8 | New insights into the cause of Parkinson's disease显示文摘 | Schapira AH Marsden CD | 1992 | Neurology1992，42，12： | 1 |
| 9 | Mete - annlysis of satisfaction with medical care: description of research domain and analysis of overall satisfaction levels显示文摘 | Judith AH Michael CD | 1988 | Soc Sci Med1988，27，6： | 1 |
| 10 | Incidence and risk factors for stroke in pregnancy and the puerperium 显示文摘 | James AH Bushnell CD Jamison MG | 2005 | Obstet Gyneeol2005，106，3： | 1 |
| 11 | Meta analysis of satisfaction with medical care:Description of research domain and analysis of overall satisfaction levels显示文摘 | Judith AH Michael CD | 1988 | Soc Sci Med1988，27，6： | 1 |
| 12 | New insights into the cause of Parkinson’s disease显示文摘 | Jenner P Schapira AH Marsden CD | 1992 | Neurology1992，42，12： | 1 |
| 13 | FGFR3 and RAS gene mutations are mutually exclusive genetic e- vents in urothelial cell carcinoma 显示文摘 | Jebar AH Hurst CD Tomlinson DC | 2005 | Oncogene2005，24，33： | 1 |
| 14 | Incidence and risk factors for stroke in pregnancy and the puerperium显示文摘 | James AH Bushnell CD Jamison MG | 2005 | Obstet Gyne- col2005，106，： | 1 |
| 15 | Autologous bone marrow transplantation for patients with non-Hodgkin's lymphoma and CNS involvement: those transplanted with active CNS disease have a poor outcome-a report by the European bone marrow transplant lymphoma registry 显示文摘 | Williams CD Pearce R Taghipour G Green ES Philip T Goldstone AH | 1994 | J Clin Oncol1994，12，11： | 1 |
| 16 | Imaging of female pelvic ma- lignancies regarding MRI, CT, and PET/CT: part 1 显示文摘 | Brocker KA Ah CD Eichbanm M | 2011 | Strahlenther Onkol2011，187，10： | 1 |
| 17 | CT colonography: the next colon screening examination显示文摘 | Johnson CD Dachman AH | 2000 | Radiology2000，216，2： | 1 |
| 18 | Primary angiosarcoma of the ovary: a case report of Stage I disease显示文摘 | Ouesenberrv CD Li C Chen AH | 2005 | Gynecol Oncol2005，99，1： | 1 |
| 19 | The culture regime suitable for the rescue of hybrid embryos in Actinidia显示文摘 | Kin MS Xiang AH Rong CD | 1995 | Acta-Horticulturae1995，，403： | 1 |
| 20 | An arbuscular mycorrhizal fungus accelerates decomposition and acquires nitrogen directly from organicmaterial显示文摘 | Hodge A Campbell CD Fitter AH | 2001 | Nature2001，413，6853： | 1 |
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