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| 1 | Development and predictive validity of the cirrhosis-associated ascites symptom scale: A cohort study of 103 patients显示文摘AIM To develop a scale of domains associated with the health-related quality-of-life(HRQOL) in patients with cirrhosis-related ascites.METHODS We initially undertook literature searches and a qualitative study in order to design a cirrhosis-associated ascites symptom(CAS) scale describing symptoms with a potential detrimental impact on health related quality of life(HRQL)(the higher the score, the worse the symptoms). Discriminatory validity was assessed in a validation cohort including cirrhotic patients with(1) tense/severe;(2) moderate/mild; or(3) no ascites(controls). Patients also completed chronic liver disease questionnaire(CLDQ) and the Euro QoL 5-Dimensions 5-Level(EQ-5D-5L) questionnaire evaluating HRQL. The relation between scale scores was analysed using Spearman correlations. RESULTS The final CAS scale included 14 items. The equivalent reliability was high(Chronbach's alpha 0.88). The validation cohort included 103 patients(72% men, mean age 62.4 years). The mean scores for each question in the CAS scale were higher for patients with severe/tense ascites than for mild/moderate ascites and controls. Compared with controls(mean = 9.9 points), the total CAS scale score was higher for severe/tense ascites(mean = 23.8 points) as well as moderate/mild ascites(mean = 18.6 points)(P < 0.001 both groups). We found a strong correlation between the total CAS and CLDQ score(rho = 0.82, P < 0.001) and a moderate correlation between the CAS and the EQ-5D-5L score(0.67, P < 0.001). CONCLUSION The CAS is a valid tool, which reflects HRQOL in patients with ascites. | Agnete Nordheim Riedel Nina Kimer Anne-Sofie Houlberg Jensen Emilie Kristine Dahl Mads Israelsen Luise Aamann Lise Lotte Gluud | 2018 | World Journal of Gastroenterology2018，24，15： | 3 |
| 2 | 显示文摘 | RODGER MA A VRUCH LI H 0 Pelvicm agnetic resonance venog-raphy reveals high rate of pelvic vein thrombosis after cesarean sectionWLEY HE | 2006 | Am J Obstet Gynecol2006，194，43： | 1 |
| 3 | Modelling and Optimization of the Assembly Process in a Flexible Cell for Aircraft Panel Manufacturing显示文摘 | Agnetic A Macchiaroli R | | 0，，3： | 1 |
| 4 | Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions显示文摘 | Agnete Kirkeby Shane Grealish Daniel A. Wolf Jenny Nelander James Wood Martin Lundblad Olle Lindvall Malin Parmar | 2012 | Cell Reports2012，，： | 1 |
| 5 | Long term cultures of hone marrow-derived human mesenehymal stem cells frequently undergo spontaneous malignant transformation显示文摘 | Rosland Gro Vatne Svendsen Agnete Torsvik Anja | 2009 | Cancer Res2009，69，13： | 1 |
| 6 | Dual rate-dependent cardiac electrophysiologic effects of haloperidol: slowing of intraventricular conduction and lengthening of repolarization 显示文摘 | Mortl D Agneter E Krivanek P | 2003 | J CardiovascPharmacol2003，41，6： | 1 |
| 7 | Trehalose indesiccated rotifers:A comparison between a bdelloidand a monogonont species显示文摘 | Manuela C Agnete K K Giulio M | 2004 | Comparative Biochem-istry-Part A:Molecular&Integrative Physiology2004，139，4： | 1 |
| 8 | Effects of antiglaucoma drugs on ocular hemodynamics in healthy volunteers 显示文摘 | Schmetterer L Strenn K Findl O Breiteneder H Graselli U Agneter E | 1997 | Clin Pharmacol Ther1997，61，5： | 1 |
| 9 | Long-term cultures of bone marrow derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation显示文摘 | Rosland Gro Vatne Svendsen Agnete Torsvik Anja | 2009 | Cancer Res2009，69，13： | 1 |
| 10 | Cell death in the injured brain : Roles of metallothioneins 显示文摘 | bile P Agnete L bleredin S | 2009 | Prog Histochem Cytochem2009，44，1： | 1 |
| 11 | Human receptors of innate immunity (CD14, TLR2) are promising targets for novel recombinant immunoglobulio-based vaccine candidates 显示文摘 | Tunheim G Keith M Agnete B | 2007 | Vaccine2007，25，40： | 1 |
| 12 | Comparison of the effects of ketamine and memantine on prolactin and cortisol release in men: a randomized, double-blind, placebo-controlled trial显示文摘 | Hergovich N Singer E Agneter E | 2001 | Neuropsychopharmacology2001，24，5： | 1 |
| 13 | Human receptors of innate immunity( CD14, TLR2 ) are promising targets for novel recombinant immunoglobulin-based vaccine candidates 显示文摘 | Tunheim G Keith M Agnete B | 2007 | Vaccine2007，25，40： | 1 |
| 14 | Dual rate-dependent cardiac electrophysiologic effects of haloperidol: slowing of intraventricular conduction and lengthening of repolarization显示文摘 | Mortl D Agneter E Krivanek P | 2003 | J Cardiovasc Pharmacol2003，41，6： | 1 |
| 15 | Decoding cancer's camouflage: epithelial-mesenchymal plasticity in resistance to immune checkpoint blockade显示文摘Epithelial-mesenchymal plasticity(EMP)of cancer cells contributes to cancer cell heterogeneity,and it is well established that EMP is a critical determinant of acquired resistance to cancer treatment modalities including radiation therapy,chemotherapy,and targeted therapies.Here,we aimed to explore how EMP contributes to cancer cell camouflage,allowing an ever-changing population of cancer cells to pass under the radar of our immune system and consequently compromise the effect of immune checkpoint blockade therapies.The ultimate clinical benefit of any combination regimen is evidenced by the sum of the drug-induced alterations observed in the variety of cellular populations composing the tumor immune microenvironment.The finely-tuned molecular crosstalk between cancer and immune cells remains to be fully elucidated,particularly for the spectrum of malignant cells along the epithelial to mesenchymal axis.High-dimensional single cell analyses of specimens collected in ongoing clinical studies is becoming a key contributor to our understanding of these interactions.This review will explore to what extent targeting EMP in combination with immune checkpoint inhibition represents a promising therapeutic avenue within the overarching strategy to reactivate a halting cancer-immunity cycle and establish a robust host immune response against cancer cells.Therapeutic strategies currently in clinical development will be discussed. | Maria L.Lotsberg Austin Rayford Jean Paul Thiery Giuliana Belleggia Stacey D’Mello Peters James B.Lorens Salem Chouaib Stephane Terry Agnete S.T.Engelsen | 2020 | Cancer Drug Resistance2020，3，4： | 0 |
| 16 | 蓝色笼子中的陨石——丹麦广播电台音乐厅显示文摘位于丹麦哥本哈根的丹麦广播电台音乐厅告诉我们建筑师让·努维尔(Jean Nouvel)除了做其他事情之外还阅读小说。这座新建筑看起来就像彼得·赫格(PetorHoeg)的获奖小说《情系冰雪》(MissSmilla’s Feeling forSnow)中描述的从天空坠落的陨石一般。 | Prof.Susanne Brenninkmeijer Torben Petersen(摄影) Bjarne Bergius Hermansen(摄影) Agnete Schlichtkrull(摄影) Laura Stamer(摄影) Philipe Ruault(摄影) | 2009 | 照明设计2009，，6： | 0 |
| 17 | 老海勒鲁普高中体育馆显示文摘位于哥本哈根北部的老海勒鲁普高中,内部拥有1100m^2的多功能大厅和最新的两层建筑,为现有学生提供了广阔的社交和创意展示空间,同时提升学校的容量,以应对持续增长的人口需求。原本校园旁边的一栋建筑里,体育设施匮乏而无法满足需求;老海勒鲁普高中也缺少大型多功能空间,用以举办体育活动、毕业典礼和社交聚会。 | Ana Merino Anders Hjortn■s Christian Alvarez Dennis Rasmussen Gül Ertekin Henrick Poulsen Hjalti Gestsson Jan Magasanik Jakob Lange Jacob Thomsen Jeppe Ecklon Ji-young Yoon Michael Sch■nemann Narisara Schr■der Riccardo Mariano Rune Hansen Snorre Nash Thomas Juul-Jensen Vincent He Xu Li Agnete Jukneviciute Ambra Chiesa Brigitta Gulyás Dennis Rasmussen Enea Michelesio Greta Krenciute H■gni Laksáfoss Isabella Eriksson Jan Magasanik Mikkel Marcker Stubgaard Jeppe Ecklon Kamilla Heskje Michael Sch■nemann Narisara Schr■der Thomas Juul-Jensen Brigitta Gulyás Enea Michelesio Jakob Lange Mikkel Marcker Stubgaard Narisara Schr■der Tobias Hjortdal Iwan Baan Peter Moldow Rasmus Hjortshoj Jens Lindhe 朱翰林 | 2019 | 城市环境设计2019，0，2： | 0 |
| 18 | 瑞士巴塞尔老工业混凝土仓房改建显示文摘巴塞尔的Transitlager坐落于Dreispitz的未来城区中心位置,是众多用于美术馆、餐厅和创意产业的新老建筑中的其中一座。它位于设想的Soho区和皇后区的边缘。与城市一样,周围的工业区域也充斥着基础设施的几何形体。通过对原仓库进行新的功能规划和扩建,使其成为一座多功能的建筑. | Agnete Jukneviciute Alexandra Gustaffson Andreas Johansen Annette Jensen Barbara Srpkova Buster Christensen Camila Stadler Dennis Rasmussen Dominic Black Enea Michelesio Erik de Haan Gül Ertekin Franck Fdida Helen Chen Ioannis Gio Jan Magasanik Jesper Andersen Lorenzo Boddi Marcelina Kolasinska Teresa Fernandez Martin Voelkle Miao Zhang Michael Sch■nemann Mikkel Marcker Stubgaard Ole Elkj■r-Larsen Ricardo Palma Ryohei Koike Sergiu Calacean Tobias Hjortdal Laurian Ghinitoiu 朱翰林(译) | 2019 | 城市环境设计2019，0，2： | 0 |
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