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| 1 | Updates in the pathophysiological mechanisms of Parkinson's disease: Emerging role of bone marrow mesenchymal stem cells显示文摘AIM: To explore the approaches exerted by mesenchymal stem cells(MSCs) to improve Parkinson's disease(PD) pathophysiology.METHODS: MSCs were harvested from bone marrowof femoral bones of male rats, grown and propagated in culture. Twenty four ovariectomized animals were classified into 3 groups: Group(1) was control, Groups(2) and(3) were subcutaneously administered with rotenone for 14 d after one month of ovariectomy for induction of PD. Then, Group(2) was left untreated, while Group(3) was treated with single intravenous dose of bone marrow derived MSCs(BM-MSCs). SRY gene was assessed by PCR in brain tissue of the female rats. Serum transforming growth factor beta-1(TGF-β1), monocyte chemoattractant protein-1(MCP-1) and brain derived neurotrophic factor(BDNF) levels were assayed by ELISA. Brain dopamine DA level was assayed fluorometrically, while brain tyrosine hydroxylase(TH) and nestin gene expression were detected by semi-quantitative real time PCR. Brain survivin expression was determined by immunohistochemical procedure. Histopathological investigation of brain tissues was also done.RESULTS: BM-MSCs were able to home at the injured brains and elicited significant decrease in serum TGF-β1(489.7 ± 13.0 vs 691.2 ± 8.0, P < 0.05) and MCP-1(89.6 ± 2.0 vs 112.1 ± 1.9, P < 0.05) levels associated with significant increase in serum BDNF(3663 ± 17.8 vs 2905 ± 72.9, P < 0.05) and brain DA(874 ± 15.0 vs 599 ± 9.8, P < 0.05) levels as well as brain TH(1.18 ± 0.004 vs 0.54 ± 0.009, P < 0.05) and nestin(1.29 ± 0.005 vs 0.67 ± 0.006, P < 0.05) genes expression levels. In addition to, producing insignificant increase in the number of positive cells for survivin(293.2 ± 15.9 vs 271.5 ± 15.9, P > 0.05) expression. Finally, the brain sections showed intact histological structure of the striatum as a result of treatment with BM-MSCs. CONCLUSION: The current study sheds light on the therapeutic potential of BM-MSCs against PD pathophysiology via multi-mechanistic actions. | Hanaa H Ahmed Ahmed M Salem Hazem M Atta Emad F Eskandar Abdel Razik H Farrag Mohamed A Ghazy Neveen A Salem Hadeer A Aglan | 2016 | World Journal of Stem Cells2016，8，3： | 9 |
| 2 | Usefulness of raw bagasse for oil absorption: A comparison of raw and acylated bagasse and their components 显示文摘 | EL-AZIZ A A S LUDWICK A G AGLAN H A | 2009 | Bioresource Technology2009，100，： | 1 |
| 3 | Processing condi- tions-fracture toughness relationships of asphalt con- crete mixtures 显示文摘 | Aglan H Othman A Figueroa L | 1994 | Journal of Materials Science1994，29，18： | 1 |
| 4 | Microstructural origin of strength and toughness of epoxy nanocomposites显示文摘 | Gunguli S Aglan H | 2005 | Journal of Elastomers and Plastics2005，37，1： | 1 |
| 5 | Microstruc- ture-fracmm behavior relationships of slot-welded rail steels 显示文摘 | Aldinton Allie Heshmat Aglan Mahmood Fateh | 2011 | Metallurgical and Materials Transactions A2011，42，： | 1 |
| 6 | Prediction model for CO_2 generation and decay in building envelopes显示文摘 | Aglan H A | 2003 | Journal Applied Physics2003，93，5： | 1 |
| 7 | Do adipose tissue-derived mesenchymal stem cells ameliorate Parkinson’s disease in rat model?显示文摘 | Ahmed HH Salem AM Atta HM Ghazy MA Aglan HA | 2014 | Human and Experimental Toxicology2014，，12： | 1 |
| 8 | Mechanical and fracture behavior of bainitic rail steel显示文摘 | Aglan H A Liu Z Y Hassan M F | 2004 | J Mater Proc Techn2004，151，： | 1 |
| 9 | 显示文摘 | Said A E A A Ludwick A G Aglan H A | 2009 | Bioresource Technology2009，100，7： | 1 |
| 10 | Identification of a frameshift mutation in Osterix in a patient with recessive ost eogenesis imperfecta显示文摘 | Lapunzina P Aglan M Temtamy S | | 0，，1： | 1 |
| 11 | Usefulness of raw bagasse for oil absorption: A comparison of raw and acylated bagasse and their components 显示文摘 | SAID A E A LUDWICK A G AGLAN H A | 2009 | Bioresource Technology2009，100，： | 1 |
| 12 | Design guidelines for composite patches bonded to cracked aluminum substrates显示文摘 | AGLAN H A GAN Y X WANG Q Y | 2002 | Journal of Adhesion Science & Technology2002，16，2： | 1 |
| 13 | Mechanical and fracture behavior of bainitic rail steel显示文摘 | Aglan H A Liu Z Y Hassan M F | 2004 | Journal of Materials Processing Technology2004，151，9： | 1 |
| 14 | Identification of a frameshift mutation in Ostefix in a patient with recessive osteogene- sis imperfecta显示文摘 | Lapunzina P Aglan M Temtamy S | 2010 | Am J Hum Genet2010，87，1： | 1 |
| 15 | Damage-evolution approach to fatigue cracking in pavements显示文摘 | H A Aglan | 1993 | Journal of Engineering Mechanics1993，119，6： | 1 |
| 16 | Left anterior descending coronary artery myocardial bridging by multislice computed tomography:correlation with clinical findings显示文摘 | Jodocy D Aglan I Friedrich G | 2010 | Eur J Radiol2010，73，1： | 1 |
| 17 | Microstructure- fracture toughness relationship of vanadium alloy/stainless steel brazed joints显示文摘 | GAN Y X AGLAN H A STEWARD R V | 2001 | Journal of Nuclear Materials2001，299，： | 1 |
| 18 | Fatigue failure mechanisms of vanadium alloy/stainless steel brazed joints显示文摘 | GAN Y X AGLAN H A STEWARD R V | 2001 | Journal of Materials Science Letters2001，20，： | 1 |
| 19 | Usefulness of raw bagasse for oil absorption: A comparison of raw and acylated bagasse and their components显示文摘 | Said A E Ludwick A Aglan H | 2009 | Bioresource Technology2009，10，7： | 1 |
| 20 | Microstructure origin of strength and toughness of a premium rail steel显示文摘 | A. M. Khourshid Y. X. Gan H. A. Aglan | 2001 | Journal of Materials Engineering and Performance2001，，3： | 1 |
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