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| 1 | The importance of glutathione and phytochelatins on the selenite and arsenate detoxification in Arabidopsis thaliana显示文摘We investigated the role of glutathione(GSH) and phytochelatins(PCs) on the detoxification of selenite using Arabidopsis thaliana. The wild-type(WT) of Arabidopsis thaliana and its mutants(glutathione deficient Cad 2–1 and phytochelatins deficient Cad 1–3) were separately exposed to varying concentrations of selenite and arsenate and jointly to both toxicants to determine their sensitivities. The results of the study revealed that, the mutants were about 20-fold more sensitive to arsenate than the WT, an indication that the GSH and PCs affect arsenate detoxification. On the contrary, the WT and both mutants showed a similar level of sensitivity to selenite, an indication that the GSH and PCs do not significantly affect selenite detoxification. However, the WT is about 8 times more sensitive to selenite than to arsenate, and the mutants were more resistant to selenite than arsenate by a factor of 2. This could not be explained by the accumulation of both elements in roots and shoots in exposure experiments. The co-exposure of the WT indicates a synergistic effect with regards to toxicity since selenite did not induce PCs but arsenic and selenium compete in their PC binding as revealed by speciation analysis of the root extracts using HPLC–ICP–MS/ESI–MS. In the absence of PCs an antagonistic effect has been detected which might suggest indirectly that the formation of Se glutathione complex prevent the formation of detrimental selenopeptides. This study, therefore, revealed that PC and GSH have only a subordinate role in the detoxification of selenite. | Fatai Adigun Aborode Andrea Raab Matthias Voigt Leticia Malta Costa Eva M.Krupp Joerg Feldmann | 2016 | Journal of Environmental Sciences2016，28，11： | 6 |
| 2 | Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis显示文摘 | Goepfert TM Adigun YE Zhong L | 2002 | Cancer Res2002，62，14： | 1 |
| 3 | Disparate developmental neurotoxi- cants converge on the cyclic AMP signaling cascade, revealed by tran- scriptional profiles in vitro and in vivo显示文摘 | Adigun AA Seidler FJ Slotkin TA | 2010 | Brain Res2010，1316，： | 1 |
| 4 | Mechanistic study of the hydrothermal reduction of palladium on the Tobacco Mosaic Virus 显示文摘 | Adigun O O Freer A S Miller J T | 2015 | J Colloid Interface Sci2015，450，： | 1 |
| 5 | Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis显示文摘 | Goepfert T M Adigun Y E Zhong L | 2002 | Cancer Res2002，62，14： | 1 |
| 6 | Sources of jobmotivations and satisfactions among British and Nigerian employees显示文摘 | Adigun IO & Stephenon GM | 1992 | The journal of social psychology1992，132，3： | 1 |
| 7 | Effect of cirrhosis and liver transplantation on the gender difference in QT interval显示文摘 | Adegboyega Q. Adigun Amar G. Pinto David A. Flockhart J. Christopher Gorski Lang Li Stephen D. Hall Naga Chalasani | 2005 | The American Journal of Cardiology2005，，5： | 1 |
| 8 | Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis 显示文摘 | Goepfert T Adigun YE Zhong L | 2002 | Cancer Res2002，62，14： | 1 |
| 9 | Chronic administration of aqueous extract of Hibiscus sabdariffa attenuates hypertension and reverses cardiac hypertrophy in 2K-1C hypertensive rats 显示文摘 | Odigie I P Ettarh R R Adigun S A | 2003 | J Ethnopharmacol2003，86，23： | 1 |
| 10 | Longitudinal melanonychia:when to biopsy and is dermoscopy helpful? 显示文摘 | Adigun CG Scher RK | 2012 | Dermatologic Therapy2012，25，6： | 1 |
| 11 | Com- parison of intravenous ephedrine with phenylephrine for the maintenance of arterial blood pressure during elec- tive caesarean section under spinal anaesthesia 显示文摘 | Adigun TA Amanor - Boadu SD Soyannwo OA | 2010 | Afr J Med Sci2010，39，1： | 1 |
| 12 | Centrosome amplification and overexpression of aurora are early events in rat mammary carcinogenesis显示文摘 | Goepfert TM Adigun YE Zhong L | 2002 | Cancer Res2002，62，14： | 1 |
| 13 | Chronic administration of aqueous extract of Hibiscus sabdariffa attenuates hypertension and reverses cardiac hypertrophy in 2K-1C hypertensive rats显示文摘 | Odigie I P Ettarh R R Adigun S A | 2003 | J Ethnopharmacol2003，86，： | 1 |
| 14 | Dose-dependent changes in some haematologieal parameters during short-term administration of Hibiscus sabdariffa ealyx aqueous extract (Zobo) in Wistar albino rats 显示文摘 | Adigun M O Ogundipe O D Anetor J I | 2006 | Afr J Med Sci2006，35，1： | 1 |
| 15 | Factors influencing the immediate post- operative outcome in operated head injured patients in Ibadan, Nigeria显示文摘 | Adigun TA Adeolu AA | 2012 | Aft J Med Med Sci2012，41，3： | 1 |
| 16 | Factors influencing the immediate postoperative outcome in operated head injured patients in Ibadan,Nigeria显示文摘 | Adigun TA Adeolu AA | | 0，，03： | 1 |
| 17 | Effect of sensitization heat treatment on properties of Al-Mg alloy AA5083-H116显示文摘 | OGUOCHA I N A ADIGUN O J YANNACOPOULOS S | 2008 | Journal of Materials Science2008，43，12： | 1 |
| 18 | Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis 显示文摘 | Goepfert TM Adigun YE Zhong L | 2002 | Cancer Res2002，62，14： | 1 |
| 19 | Vitamin C lowers blood pressure and alters vascular responsiveness in salt-induced hypertension显示文摘 | Ettarh RR Odigie IP Adigun SA | 2002 | Can J Physiol Pharmacol2002，80，： | 1 |
| 20 | Sources of Job Motivation and Satisfaction among British and Nigerian Employees 显示文摘 | Adigun S O Stephenson G M | 1999 | The Journal of Social Psychology1999，132，3： | 1 |
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